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Mouse TNF-alpha Quantikine ELISA Kit, 2 Plate

(MTA00B)



概述
货号 MTA00B
描述

The Quantikine Mouse TNF-alpha Immunoassay is a 4.5 hour solid phase ELISA designed to measure mouse TNF-alpha levels in cell culture supernates, serum, and plasma. It contains E. coli-expressed recombinant mouse TNF-alpha and antibodies raised against the recombinant factor. This immunoassay has been shown to quantitate the recombinant mouse TNF-alpha accurately. Results obtained using natural mouse TNF-alpha showed dose-response curves that were parallel to the standard curves obtained using the recombinant kit standards. These results indicate that this kit can be used to determine relative mass values for natural mouse TNF-alpha.

别名 APC1 protein; Cachectin; Cachetin; DIF; TNF; TNF, monocyte-derived; tnfa; tnf-a; TNF-alphacachectin; TNFATNF, macrophage-derived; TNFSF1A; TNFSF2; TNFSF2TNF superfamily, member 2; tumor necrosis factor (TNF superfamily, member 2); tumor necrosis factor alpha; Tumor necrosis factor ligand superfamily member 2; tumor necrosis factor; tumor necrosis factor-alpha;
全称
Tumor Necrosis Factor alpha
反应种属 Mouse
目标/特异性 Natural and recombinant mouse TNF-alpha.
性能
供应商 R&D Systems
Entrez Gene IDs
7124 (Human); 21926 (Mouse); 24835 (Rat); 397086 (Porcine); 280943 (Bovine); 403922 (Canine); 100033834 (Equine); 493755 (Feline); 100009088 (Rabbit)
应用文献
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

Carcinoma-astrocyte gap junctions promote brain metastasis by cGAMP transfer
Nature, 2016;533(7604):493-8.
Species: Mouse
Sample Type: Cell Culture Supernates

Toll-like Receptor 4 Agonistic Antibody Promotes Host Defense against Chronic Pseudomonas aeruginosa Lung Infection in Mice
Authors: S Nakamura, N Iwanaga, M Seki, K Fukudome, K Oshima, T Miyazaki, K Izumikawa, K Yanagihara, Y Miyazaki, H Mukae, S Kohno
Infect Immun, 2016;0(0):.
Species: Mouse
Sample Type: Tissue Homogenates

Sphingosine-1-Phosphate Receptor 2 Regulates Proinflammatory Cytokine Production and Osteoclastogenesis
PLoS ONE, 2016;11(5):e0156303.
Species: Mouse
Sample Type: Cell Culture Supernates

DNMT1-PPAR? pathway in macrophages regulates chronic inflammation and atherosclerosis development in mice
Sci Rep, 2016;6(0):30053.
Species: Mouse
Sample Type: Plasma

Toll-Like Receptor 4 Signaling Pathway Mediates Inhalant Organic Dust-Induced Bone Loss
PLoS ONE, 2016;11(8):e0158735.
Species: Mouse
Sample Type: BALF

Subtilisin-like protease-1 secreted through type IV secretion system contributes to high virulence of Streptococcus suis 2
Authors: Supeng Yin
Sci Rep, 2016;6(0):27369.
Species: Mouse
Sample Type: Serum

TNFalpha Regulates SIRT1 Cleavage during Ocular Autoimmune Disease.
Authors: Gardner P, Yazid S, Chu C, Copland D, Adamson P, Dick A, Calder V
Am J Pathol, 2015;185(5):1324-33.
Species: Mouse
Sample Type: Serum

Sevoflurane inhibits nuclear factor-kappaB activation in lipopolysaccharide-induced acute inflammatory lung injury via toll-like receptor 4 signaling.
Authors: Sun X, Li X, Wang X, Tan W, Wang J
PLoS ONE, 2015;10(4):e0122752.
Species: Mouse
Sample Type: BALF

Chronic morphine-induced microRNA-124 promotes microglial immunosuppression by modulating P65 and TRAF6.
Authors: Qiu S, Feng Y, LeSage G, Zhang Y, Stuart C, He L, Li Y, Caudle Y, Peng Y, Yin D
J Immunol, 2015;194(3):1021-30.
Species: Mouse
Sample Type: Cell Culture Supernates

Conditioned media from adipose stromal cells limit lipopolysaccharide-induced lung injury, endothelial hyperpermeability and apoptosis.
Authors: Lu H, Poirier C, Cook T, Traktuev D, Merfeld-Clauss S, Lease B, Petrache I, March K, Bogatcheva N
J Transl Med, 2015;13(0):67.
Species: Mouse
Sample Type: BALF

Microglial Heparan Sulfate Proteoglycans Facilitate the Cluster-of-Differentiation 14 (CD14)/Toll-like Receptor 4 (TLR4)-Dependent Inflammatory Response.
Authors: O'Callaghan P, Li J, Lannfelt L, Lindahl U, Zhang X
J Biol Chem, 2015;290(24):14904-14.
Species: Mouse
Sample Type: Cell Culture Supernates

Microglial Kv1.3 Channels and P2Y12 Receptors Differentially Regulate Cytokine and Chemokine Release from Brain Slices of Young Adult and Aged Mice.
Authors: Charolidi N, Schilling T, Eder C
PLoS ONE, 2015;10(5):e0128463.
Species: Mouse
Sample Type: Cell Culture Supernates

Pycnogenol Attenuates the Release of Proinflammatory Cytokines and Expression of Perilipin 2 in Lipopolysaccharide-Stimulated Microglia in Part via Inhibition of NF-kappaB and AP-1 Activation.
Authors: Fan B, Dun S, Gu J, Guo Y, Ikuyama S
PLoS ONE, 2015;10(9):e0137837.
Species: Mouse
Sample Type: Cell Culture Supernates

HGF Gene Modification in Mesenchymal Stem Cells Reduces Radiation-Induced Intestinal Injury by Modulating Immunity.
Authors: Wang H, Sun R, Li Y, Yang Y, Xiao F, Zhang Y, Wang S, Sun H, Zhang Q, Wu C, Wang L
PLoS ONE, 2015;10(5):e0124420.
Species: Mouse
Sample Type: Serum

Administration of a CXCL12 Analog in Endotoxemia Is Associated with Anti-Inflammatory, Anti-Oxidative and Cytoprotective Effects In Vivo.
Authors: Seemann S, Lupp A
PLoS ONE, 2015;10(9):e0138389.
Species: Mouse
Sample Type: Serum

Cocaine-mediated induction of microglial activation involves the ER stress-TLR2 axis.
Authors: Liao K, Guo M, Niu F, Yang L, Callen S, Buch S
J Neuroinflammation, 2015;13(1):33.
Species: Mouse
Sample Type: Cell Culture Supernates

IRAK-M regulates the inhibition of TLR-mediated macrophage immune response during late in vitro Leishmania donovani infection.
Authors: Srivastav S, Saha A, Barua J, Ukil A, Das P
Eur J Immunol, 2015;45(10):2787-97.
Species: Mouse
Sample Type: Cell Culture Supernates

Pharmacological Ascorbate Radiosensitizes Pancreatic Cancer.
Authors: Du J, Cieslak J, Welsh J, Sibenaller Z, Allen B, Wagner B, Kalen A, Doskey C, Strother R, Button A, Mott S, Smith B, Tsai S, Mezhir J, Goswami P, Spitz D, Buettner G, Cullen J
Cancer Res, 2015;75(16):3314-26.
Species: Mouse
Sample Type: Serum

Methemoglobin is an endogenous toll-like receptor 4 ligand-relevance to subarachnoid hemorrhage.
Authors: Kwon M, Woo S, Kurland D, Yoon S, Palmer A, Banerjee U, Iqbal S, Ivanova S, Gerzanich V, Simard J
Int J Mol Sci, 2015;16(3):5028-46.
Species: Mouse
Sample Type: Cell Culture Supernates

Innate sensing of microbial products promotes wound-induced skin cancer.
Authors: Hoste E, Arwert E, Lal R, South A, Salas-Alanis J, Murrell D, Donati G, Watt F
Nat Commun, 2015;6(0):5932.
Species: Mouse
Sample Type: Serum

Alpha-enolase is upregulated on the cell surface and responds to plasminogen activation in mice expressing a 133p53alpha mimic.
Authors: Sawhney S, Hood K, Shaw A, Braithwaite A, Stubbs R, Hung N, Royds J, Slatter T
PLoS ONE, 2015;10(2):e0116270.
Species: Mouse
Sample Type: Cell Culture Supernates

Fat storage-inducing transmembrane protein 2 is required for normal fat storage in adipose tissue.
Authors: Miranda, Diego A, Kim, Ji-Hyun, Nguyen, Long N, Cheng, Wang, Tan, Bryan C, Goh, Vera J, Tan, Jolene S, Yaligar, Jadegoud, Kn, Bhanu Pr, Velan, S Sendhi, Wang, Hongyan, Silver, David L
J Biol Chem, 2014;289(14):9560-72.
Species: Mouse
Sample Type: Plasma

Neurodegeneration by activation of the microglial complement-phagosome pathway.
Authors: Bodea L, Wang Y, Linnartz-Gerlach B, Kopatz J, Sinkkonen L, Musgrove R, Kaoma T, Muller A, Vallar L, Di Monte D, Balling R, Neumann H
J Neurosci, 2014;34(25):8546-56.
Species: Mouse
Sample Type: Plasma

OPG/RANKL/RANK axis is a critical inflammatory signaling system in ischemic brain in mice.
Authors: Shimamura M, Nakagami H, Osako M, Kurinami H, Koriyama H, Zhengda P, Tomioka H, Tenma A, Wakayama K, Morishita R
Proc Natl Acad Sci U S A, 2014;111(22):8191-6.
Species: Mouse
Sample Type: cell culture supernate

Akt2 deficiency protects from acute lung injury via alternative macrophage activation and miR-146a induction in mice.
Authors: Vergadi, Eleni, Vaporidi, Katerina, Theodorakis, Emmanuel, Doxaki, Christin, Lagoudaki, Eleni, Ieronymaki, Elefther, Alexaki, Vassilia, Helms, Mike, Kondili, Eumorfia, Soennichsen, Birte, Stathopoulos, Efstathi, Margioris, Andrew N, Georgopoulos, Dimitrio, Tsatsanis, Christos
J Immunol, 2014;192(1):394-406.
Species: Mouse
Sample Type: BALF

JAK/STAT1 signaling promotes HMGB1 hyperacetylation and nuclear translocation.
Authors: Lu B, Antoine D, Kwan K, Lundback P, Wahamaa H, Schierbeck H, Robinson M, Van Zoelen M, Yang H, Li J, Erlandsson-Harris H, Chavan S, Wang H, Andersson U, Tracey K
Proc Natl Acad Sci U S A, 2014;111(8):3068-73.
Species: Mouse
Sample Type: Culture Media

Effects of a high-fat diet on spontaneous metastasis of Lewis lung carcinoma in plasminogen activator inhibitor-1 deficient and wild-type mice.
Authors: Yan L, DeMars L
PLoS ONE, 2014;9(10):e110869.
Species: Mouse
Sample Type: Plasma

Hypomorphic mutation in the RAG2 gene affects dendritic cell distribution and migration.
Authors: Maina, Virginia, Marrella, Veronica, Mantero, Stefano, Cassani, Barbara, Fontana, Elena, Anselmo, Achille, Del Prete, Annalisa, Sozzani, Silvano, Vezzoni, Paolo, Poliani, Pietro L, Villa, Anna
J Leukoc Biol, 2013;94(6):1221-30.
Species: Mouse
Sample Type: Tissue Homogenates

A hydrogen sulfide-releasing cyclooxygenase inhibitor markedly accelerates recovery from experimental spinal cord injury.
Authors: Campolo M, Esposito E, Ahmad A, Di Paola R, Wallace J, Cuzzocrea S
FASEB J, 2013;27(11):4489-99.
Species: Mouse
Sample Type: Whole Tissue

Lyn mitigates mouse airway remodeling by downregulating the TGF-beta3 isoform in house dust mite models.
Authors: Li G, Fox J, Liu Z, Liu J, Gao G, Jin Y, Gao H, Wu M
J Immunol, 2013;191(11):5359-70.
Species: Mouse
Sample Type: BALF

Akt Regulates TNFalpha synthesis downstream of RIP1 kinase activation during necroptosis.
Authors: McNamara C, Ahuja R, Osafo-Addo A, Barrows D, Kettenbach A, Skidan I, Teng X, Cuny G, Gerber S, Degterev A
PLoS ONE, 2013;8(3):e56576.
Species: Mouse
Sample Type: Cell Lysates

mTORC1 and mTORC2 play different roles in the functional survival of transplanted adipose-derived stromal cells in hind limb ischemic mice via regulating inflammation in vivo.
Authors: Fan W, Cheng K, Qin X, Narsinh K, Wang S, Hu S, Wang Y, Chen Y, Wu J, Xiong L, Cao F
Stem Cells, 2013;31(1):203-14.
Species: Mouse
Sample Type: Tissue Lysate

Inhibiting Mer receptor tyrosine kinase suppresses STAT1, SOCS1/3, and NF-kappaB activation and enhances inflammatory responses in lipopolysaccharide-induced acute lung injury.
J. Cell. Sci., 2012;91(6):921-32.
Species: Mouse
Sample Type: BALF

A novel small molecule, HK-156, inhibits lipopolysaccharide-induced activation of NF-kappaB signaling and improves survival in mouse models of sepsis.
Acta Pharmacol. Sin., 2012;33(9):1204-16.
Species: Mouse
Sample Type: Serum

The Receptor Slamf1 on the Surface of Myeloid Lineage Cells Controls Susceptibility to Infection by Trypanosoma cruzi.
Authors: Calderon J, Maganto-Garcia E, Punzon C, Carrion J, Terhorst C, Fresno M
PLoS Pathog., 2012;8(7):e1002799.
Species: Mouse
Sample Type: Serum

Salmonella enterica induces joint inflammation and expression of interleukin-17 in draining lymph nodes early after onset of enterocolitis in mice.
Authors: Noto Llana M, Sarnacki SH, Vazquez MV, Gartner AS, Giacomodonato MN, Cerquetti MC
Infect. Immun., 2012;80(6):2231-9.
Species: Mouse
Sample Type: Tissue Homogenates

Human mesenchymal stem/stromal cells cultured as spheroids are self-activated to produce prostaglandin E2 that directs stimulated macrophages into an anti-inflammatory phenotype.
Authors: Ylostalo J, Bartosh T, Coble K, Prockop D
Stem Cells, 2012;30(10):2283-96.
Species: Mouse
Sample Type: Cell Culture Supernates

Cutting edge: Divergent cell-specific functions of MyD88 for inflammatory responses and organ injury in septic peritonitis.
Authors: Gais P, Reim D, Jusek G, Rossmann-Bloeck T, Weighardt H, Pfeffer K, Altmayr F, Janssen KP, Holzmann B
J. Immunol., 2012;188(12):5833-7.
Species: Mouse
Sample Type: Plasma

Disruption of the chemokine-like receptor-1 (CMKLR1) gene is associated with reduced adiposity and glucose intolerance.
Authors: Ernst MC, Haidl ID, Zúñiga LA, Dranse HJ, Rourke JL, Zabel BA, Butcher EC, Sinal CJ
Endocrinology, 2012;153(2):672-82.
Species: Mouse
Sample Type: Serum

Fetuin-A acts as an endogenous ligand of TLR4 to promote lipid-induced insulin resistance.
Nat Med, 2012;18(0):1279.
Species: Mouse
Sample Type: Serum

Protein kinase C delta (PKCdelta)-extracellular signal-regulated kinase 1/2 (ERK1/2) signaling cascade regulates glycogen synthase kinase-3 (GSK-3) inhibition-mediated interleukin-10 (IL-10) expression in lipopolysaccharide (LPS)-induced endotoxemia.
Authors: Noh KT, Son KH, Jung ID, Kang HK, Hwang SA, Lee WS, You JC, Park YM
J. Biol. Chem., 2012;287(17):14226-33.
Species: Mouse
Sample Type: Serum

Treatment of diabetic mice with undenatured whey protein accelerates the wound healing process by enhancing the expression of MIP-1alpha, MIP-2, KC, CX3CL1 and TGF-beta in wounded tissue.
BMC Immunol., 2012;13(0):32.
Species: Mouse
Sample Type: Tissue Homogenates

The axonal guidance receptor neogenin promotes acute inflammation.
Authors: Konig K, Gatidou D, Granja T, Meier J, Rosenberger P, Mirakaj V
PLoS ONE, 2012;7(3):e32145.
Species: Mouse
Sample Type: Peritoneal Lavage

Toll-like receptor-mediated inhibition of Gas6 and ProS expression facilitates inflammatory cytokine production in mouse macrophages.
Authors: Deng T, Zhang Y, Chen Q, Yan K, Han D
Immunology, 2012;135(1):40-50.
Species: Mouse
Sample Type: Cell Culture Supernates

Netrin-1 protects against L-Arginine-induced acute pancreatitis in mice.
Authors: Chen J, Cai Q, Shen P, Yan R, Wang C, Yang D, Fu H, Chen X
PLoS ONE, 2012;7(9):e46201.
Species: Mouse
Sample Type: Plasma

Adipocyte-specific protein tyrosine phosphatase 1B deletion increases lipogenesis, adipocyte cell size and is a minor regulator of glucose homeostasis.
Authors: Owen C, Czopek A, Agouni A, Grant L, Judson R, Lees EK, Mcilroy GD, Goransson O, Welch A, Bence KK, Kahn BB, Neel BG, Mody N, Delibegovic M
PLoS ONE, 2012;7(2):e32700.
Species: Mouse
Sample Type: Serum

Priming with endotoxin increases acute lung injury in mice by enhancing the severity of lung endothelial injury.
Authors: Lee JS, Su X, Rackley C, Matthay MA, Gupta N
Anat Rec (Hoboken), 2012;294(1):165-72.
Species: Mouse
Sample Type: BALF

Stress augments insulin resistance and prothrombotic state: role of visceral adipose-derived monocyte chemoattractant protein-1.
Authors: Uchida Y, Takeshita K, Yamamoto K, Kikuchi R, Nakayama T, Nomura M, Cheng XW, Egashira K, Matsushita T, Nakamura H, Murohara T
Diabetes, 2012;61(6):1552-61.
Species: Mouse
Sample Type: Serum

TLR-mediated distinct IFN-gamma/IL-10 pattern induces protective immunity against murine visceral leishmaniasis.
Eur. J. Immunol., 2012;42(8):2087-99.
Species: Mouse
Sample Type: Cell Culture Supernates

Endothelial cell peroxisome proliferator-activated receptor gamma reduces endotoxemic pulmonary inflammation and injury.
Authors: Reddy A, Lakshmi S, Kleinhenz J, Sutliff R, Hart C, Reddy R
J Immunol, 2012;189(11):5411-20.
Species: Mouse
Sample Type: BALF

The adaptor molecule CARD9 is essential for tuberculosis control.
Authors: Dorhoi A, Desel C, Yeremeev V, Pradl L, Brinkmann V, Mollenkopf HJ, Hanke K, Gross O, Ruland J, Kaufmann SH
J. Exp. Med., 2011;207(4):777-92.
Species: Mouse
Sample Type: Cell Culture Supernates

Crawling Phagocytes Recruited in the Brain Vasculature after Pertussis Toxin Exposure through IL6, ICAM1 and ITGalphaM.
Authors: Richard JF, Roy M, Audoy-Remus J, Tremblay P, Vallieres L
Brain Pathol., 2011;21(0):661.
Species: Mouse
Sample Type: Serum

Role of IL-17A in neutrophil recruitment and hepatic injury after warm ischemia-reperfusion mice.
Authors: Kono H, Fujii H, Ogiku M, Hosomura N, Amemiya H, Tsuchiya M, Hara M
J. Immunol., 2011;187(9):4818-25.
Species: Mouse
Sample Type: Serum

Deletion of tristetraprolin caused spontaneous reactive granulopoiesis by a non-cell-autonomous mechanism without disturbing long-term hematopoietic stem cell quiescence.
Authors: Kaplan IM, Morisot S, Heiser D, Cheng WC, Kim MJ, Civin CI
J. Immunol., 2011;186(5):2826-34.
Species: Mouse
Sample Type: Plasma

Anti-inflammatory protein TSG-6 secreted by activated MSCs attenuates zymosan-induced mouse peritonitis by decreasing TLR2/NF-kappaB signaling in resident macrophages.
Authors: Choi H, Lee RH, Bazhanov N, Oh JY, Prockop DJ
Blood, 2011;118(2):330-8.
Species: Mouse
Sample Type: Peritoneal Lavage

Repulsive guidance molecule-A (RGM-A) inhibits leukocyte migration and mitigates inflammation.
Authors: Mirakaj V, Brown S, Laucher S, Steinl C, Klein G, Kohler D, Skutella T, Meisel C, Brommer B, Rosenberger P, Schwab JM
Proc. Natl. Acad. Sci. U.S.A., 2011;108(16):6555-60.
Species: Mouse
Sample Type: Peritoneal Lavage

IL-33-activated dendritic cells are critical for allergic airway inflammation.
Authors: Besnard AG, Togbe D, Guillou N, Erard F, Quesniaux V, Ryffel B
Eur. J. Immunol., 2011;41(6):1675-86.
Species: Mouse
Sample Type: BALF

Differential host determinants contribute to the pathogenesis of 2009 pandemic H1N1 and human H5N1 influenza A viruses in experimental mouse models.
Authors: Otte A, Sauter M, Alleva L, Baumgarte S, Klingel K, Gabriel G
Am. J. Pathol., 2011;179(1):230-9.
Species: Mouse
Sample Type: Serum

Tumors Suppress In Situ Proliferation of Cytotoxic T Cells by Promoting Differentiation of Gr-1+ Conventional Dendritic Cells through IL-6.
Authors: Diao J, Zhao J, Winter E
J. Immunol., 2011;186(9):5058-67.
Species: Mouse
Sample Type: Cell Culture Supernates

The interaction between IL-18 and IL-18 receptor limits the magnitude of protective immunity and enhances pathogenic responses following infection with intracellular bacteria.
Authors: Ghose P, Ali AQ, Fang R, Forbes D, Ballard B, Ismail N
J. Immunol., 2011;187(3):1333-46.
Species: Mouse
Sample Type: Serum

HIF-VEGF pathways are critical for chronic otitis media in Junbo and Jeff mouse mutants.
Authors: Cheeseman MT, Tyrer HE, Williams D, Hough TA, Pathak P, Romero MR, Hilton H, Bali S, Parker A, Vizor L, Purnell T, Vowell K, Wells S, Bhutta MF, Potter PK, Brown SD
PLoS Genet., 2011;7(10):e1002336.
Species: Mouse
Sample Type: Serum

Overexpression of sICAM-1 in the Alveolar Epithelial Space Results in an Exaggerated Inflammatory Response and Early Death in Gram Negative Pneumonia.
Authors: Mendez MP, Monroy YK, Du M
Respir. Res., 2011;12(1):12.
Species: Mouse
Sample Type: Cell Culture Supernates

Serotonin activates dendritic cell function in the context of gut inflammation.
Authors: Li N, Ghia JE, Wang H, McClemens J, Cote F, Suehiro Y, Mallet J, Khan WI
Am. J. Pathol., 2011;178(2):662-71.
Species: Mouse
Sample Type: Tissue Homogenates

Histone Deacetylase Inhibitor LAQ824 Augments Inflammatory Responses in Macrophages through Transcriptional Regulation of IL-10.
Authors: Wang H, Cheng F
J. Immunol., 2011;186(0):3986.
Species: Mouse
Sample Type: Cell Culture Supernates

Anti-inflammatory role of microsomal prostaglandin E synthase-1 in a model of neuroinflammation.
Authors: Brenneis C, Coste O, Altenrath K, Angioni C, Schmidt H, Schuh CD, Zhang DD, Henke M, Weigert A, Brune B, Rubin B, Nusing R, Scholich K, Geisslinger G
J. Biol. Chem., 2011;286(3):2331-42.
Species: Mouse
Sample Type: Cell Culture Supernates

TLR4 through IFN-beta promotes low molecular mass hyaluronan-induced neutrophil apoptosis.
Authors: Leu SW, Shi L, Xu C, Zhao Y, Liu B, Li Y, Shiedlin A, Xiang C, Shen H, Quinn DA, Hales CA, Zhao H
J. Immunol., 2011;186(1):556-62.
Species: Mouse
Sample Type: BALF

Sterol regulatory element-binding protein 2 (SREBP2) activation after excess triglyceride storage induces chemerin in hypertrophic adipocytes.
Authors: Bauer S, Wanninger J, Schmidhofer S, Weigert J, Neumeier M, Dorn C, Hellerbrand C, Zimara N, Schaffler A, Aslanidis C, Buechler C
Endocrinology, 2011;152(1):26-35.
Species: Mouse
Sample Type: Cell Culture Supernates

WNT5A Signaling Contributes to Abeta-Induced Neuroinflammation and Neurotoxicity.
Authors: Li B, Zhong L, Yang X, Andersson T, Huang M, Tang SJ
PLoS ONE, 2011;6(8):e22920.
Species: Mouse
Sample Type: Cell Culture Supernates

Enhanced production of IL-17A during zymosan-induced peritonitis in obese mice.
Authors: Pini M, Fantuzzi G
J. Leukoc. Biol., 2010;87(1):51-8.
Species: Mouse
Sample Type: Peritoneal Lavage

Early protection from burn-induced acute lung injury by deletion of preprotachykinin-A gene.
Authors: Sio SW, Moochhala S, Lu J
Am. J. Respir. Crit. Care Med., 2010;181(1):36-46.
Species: Mouse
Sample Type: Tissue Homogenates

Varying susceptibility of pulmonary cytokine production to lipopolysaccharide in mice.
Authors: Alm AS, Li K, Yang D, Andersson R, Lu Y, Wang X
Cytokine, 2010;49(3):256-63.
Species: Mouse
Sample Type: BALF

Reciprocal coupling of coagulation and innate immunity via neutrophil serine proteases.
Authors: Massberg S, Grahl L, von Bruehl ML, Manukyan D, Pfeiler S, Goosmann C, Brinkmann V, Lorenz M, Bidzhekov K, Khandagale AB, Konrad I, Kennerknecht E, Reges K, Holdenrieder S, Braun S, Reinhardt C, Spannagl M, Preissner KT, Engelmann B
Nat. Med., 2010;16(8):887-96.
Species: Mouse
Sample Type: Plasma

Proinflammatory clearance of apoptotic neutrophils induces an IL-12(low)IL-10(high) regulatory phenotype in macrophages.
Authors: Filardy AA, Pires DR, Nunes MP, Takiya CM, Freire-de-Lima CG, Ribeiro-Gomes FL, DosReis GA
J. Immunol., 2010;185(4):2044-50.
Species: Mouse
Sample Type: Cell Culture Supernates

Epithelial overexpression of SOCS-3 in transgenic mice exacerbates wound inflammation in the presence of elevated TGF-beta1.
Authors: Linke A, Goren I, Bosl MR, Pfeilschifter J, Frank S
J. Invest. Dermatol., 2010;130(3):866-75.
Species: Mouse
Sample Type: Tissue Homogenates

S100A8/A9 is not involved in host defense against murine urinary tract infection.
Authors: Dessing MC, Butter LM, Teske GJ
PLoS ONE, 2010;5(10):e13394.
Species: Mouse
Sample Type: Tissue Homogenates

Systemic inflammation sensitizes the neonatal brain to excitotoxicity through a pro-/anti-inflammatory imbalance: key role of TNFalpha pathway and protection by etanercept.
Authors: Aden U, Favrais G, Plaisant F, Winerdal M, Felderhoff-Mueser U, Lampa J, Lelievre V, Gressens P
Brain Behav. Immun., 2010;24(5):747-58.
Species: Mouse
Sample Type: Tissue Homogenates

Cytotoxins of the human pathogen Aeromonas hydrophila trigger, via the NLRP3 inflammasome, caspase-1 activation in macrophages.
Authors: McCoy AJ, Koizumi Y, Toma C, Higa N, Dixit V, Taniguchi S, Tschopp J, Suzuki T
Eur. J. Immunol., 2010;40(10):2797-803.
Species: Mouse
Sample Type: Cell Culture Supernates

TLR4 is a negative regulator in noninfectious lung inflammation.
Authors: Zhao H, Leu SW, Shi L, Dedaj R, Zhao G, Garg HG, Shen L, Lien E, Fitzgerald KA, Shiedlin A, Shen H, Quinn DA, Hales CA
J. Immunol., 2010;184(9):5308-14.
Species: Mouse
Sample Type: BALF

Microbial exposure early in life regulates airway inflammation in mice after infection with Streptococcus pneumoniae with enhancement of local resistance.
Authors: Yasuda Y, Matsumura Y, Kasahara K, Ouji N, Sugiura S, Mikasa K, Kita E
Am. J. Physiol. Lung Cell Mol. Physiol., 2010;298(1):L67-78.
Species: Mouse
Sample Type: BALF

Myeloid PTEN promotes inflammation but impairs bactericidal activities during murine pneumococcal pneumonia.
Authors: Schabbauer G, Matt U, Gunzl P, Warszawska J, Furtner T, Hainzl E, Elbau I, Mesteri I, Doninger B, Binder BR, Knapp S
J. Immunol., 2010;185(1):468-76.
Species: Mouse
Sample Type: BALF

Critical role of the disintegrin metalloprotease ADAM17 for intestinal inflammation and regeneration in mice.
Authors: Chalaris A, Adam N, Sina C, Rosenstiel P, Lehmann-Koch J, Schirmacher P, Hartmann D, Cichy J, Gavrilova O, Schreiber S, Jostock T, Matthews V, Hasler R, Becker C, Neurath MF, Reiss K, Saftig P, Scheller J, Rose-John S
J. Exp. Med., 2010;207(8):1617-24.
Species: Mouse
Sample Type: Cell Culture Supernates

Ability of IDO to attenuate liver injury in alpha-galactosylceramide-induced hepatitis model.
Authors: Ito H, Hoshi M, Ohtaki H, Taguchi A, Ando K, Ishikawa T, Osawa Y, Hara A, Moriwaki H, Saito K, Seishima M
J. Immunol., 2010;185(8):4554-60.
Species: Mouse
Sample Type: Serum

eNOS plays a major role in adiponectin synthesis in adipocytes.
Authors: Koh EH, Kim M, Ranjan KC, Kim HS, Park HS, Oh KS, Park IS, Lee WJ, Kim MS, Park JY, Youn JH, Lee KU
Am. J. Physiol. Endocrinol. Metab., 2010;298(4):E846-53.
Species: Mouse
Sample Type: Plasma

Low anticoagulant heparin targets multiple sites of inflammation, suppresses heparin-induced thrombocytopenia, and inhibits interaction of RAGE with its ligands.
Authors: Rao NV, Argyle B, Xu X, Reynolds PR, Walenga JM, Prechel M, Prestwich GD, MacArthur RB, Walters BB, Hoidal JR, Kennedy TP
Am. J. Physiol., Cell Physiol., 2010;299(1):C97-110.
Species: Mouse
Sample Type: BALF

Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1beta in type 2 diabetes.
Authors: Masters SL, Dunne A, Subramanian SL, Hull RL, Tannahill GM, Sharp FA, Becker C, Franchi L, Yoshihara E, Chen Z, Mullooly N, Mielke LA, Harris J, Coll RC, Mills KH, Mok KH, Newsholme P, Nunez G, Yodoi J, Kahn SE, Lavelle EC, O'Neill LA
Nat. Immunol., 2010;11(10):897-904.
Species: Mouse
Sample Type: Cell Culture Supernates

Neutralization of osteopontin inhibits obesity-induced inflammation and insulin resistance.
Authors: Kiefer FW, Zeyda M, Gollinger K, Pfau B, Neuhofer A, Weichhart T, Saemann MD, Geyeregger R, Schlederer M, Kenner L, Stulnig TM
Diabetes, 2010;59(4):935-46.
Species: Mouse
Sample Type: Plasma

Loss of ability to self-heal malaria upon taurine transporter deletion.
Authors: Delic D, Warskulat U, Borsch E, Al-Qahtani S, Al-Quraishi S, Haussinger D, Wunderlich F
Infect. Immun., 2010;78(4):1642-9.
Species: Mouse
Sample Type: Serum

Zoledronic acid impairs myeloid differentiation to tumour-associated macrophages in mesothelioma.
Authors: Veltman JD, Lambers ME, van Nimwegen M
Br. J. Cancer, 2010;103(5):629-41.
Species: Mouse
Sample Type: Peritoneal Fluid

IL-33 shifts macrophage polarization, promoting resistance against Pseudomonas aeruginosa keratitis.
Authors: Hazlett LD, McClellan SA, Barrett RP, Huang X, Zhang Y, Wu M, Van Rooijen N, Szliter E
Invest. Ophthalmol. Vis. Sci., 2010;51(3):1524-32.
Species: Mouse
Sample Type: Tissue Homogenates

TLR4 activation is required for IL-17-induced multiple tissue inflammation and wasting in mice.
Authors: Tang H, Pang S, Wang M
J. Immunol., 2010;185(4):2563-9.
Species: Mouse
Sample Type: Tissue Homogenates

VAMP8 is essential in anaphylatoxin-induced degranulation, TNF-alpha secretion, peritonitis, and systemic inflammation.
Authors: Pushparaj PN, Tay HK, Wang CC, Hong W, Melendez AJ
J. Immunol., 2009;183(2):1413-8.
Species: Mouse
Sample Type: Serum

Bbeta(15-42) protects against acid-induced acute lung injury and secondary pseudomonas pneumonia in vivo.
Authors: Matt U, Warszawska JM, Bauer M, Dietl W, Mesteri I, Doninger B, Haslinger I, Schabbauer G, Perkmann T, Binder CJ, Reingruber S, Petzelbauer P, Knapp S
Am. J. Respir. Crit. Care Med., 2009;180(12):1208-17.
Species: Mouse
Sample Type: BALF

Inhibition of monocyte-derived inflammatory cytokines by IL-25 occurs via p38 Map kinase-dependent induction of Socs-3.
Authors: Caruso R, Stolfi C, Sarra M, Rizzo A, Fantini MC, Pallone F, MacDonald TT, Monteleone G
Blood, 2009;113(15):3512-9.
Species: Mouse
Sample Type: Serum

Simultaneous absence of surfactant proteins A and D increases lung inflammation and injury after allogeneic HSCT in mice.
Authors: Gram K, Yang S, Steiner M, Somani A, Hawgood S, Blazar BR, Panoskaltsis-Mortari A, Haddad IY
Am. J. Physiol. Lung Cell Mol. Physiol., 2009;296(2):L167-75.
Species: Mouse
Sample Type: BALF

Chrysanthemum indicum Linne extract inhibits the inflammatory response by suppressing NF-kappaB and MAPKs activation in lipopolysaccharide-induced RAW 264.7 macrophages.
Authors: Cheon MS, Yoon T, Lee do Y, Choi G, Moon BC, Lee AY, Choo BK, Kim HK
J Ethnopharmacol, 2009;122(3):473-7.
Species: Mouse
Sample Type: Cell Culture Supernates

T cells dampen innate immune responses through inhibition of NLRP1 and NLRP3 inflammasomes.
Authors: Guarda G, Dostert C, Staehli F, Cabalzar K, Castillo R, Tardivel A, Schneider P, Tschopp J
Nature, 2009;460(7252):269-73.
Species: Mouse
Sample Type: Cell Culture Supernates

IL-17 receptor signaling is required to control polymicrobial sepsis.
Authors: Freitas A, Alves-Filho JC, Victoni T, Secher T, Lemos HP, Sonego F, Cunha FQ, Ryffel B
J. Immunol., 2009;182(12):7846-54.
Species: Mouse
Sample Type: Serum

A small molecule CRTH2 antagonist inhibits FITC-induced allergic cutaneous inflammation.
Authors: Boehme SA, Franz-Bacon K, Chen EP, Sasik R, Sprague LJ, Ly TW, Hardiman G, Bacon KB
Int. Immunol., 2009;21(1):81-93.
Species: Mouse
Sample Type: Tissue Homogenates

Silencing of TLR4 decreases liver tumor burden in a murine model of colorectal metastasis and hepatic steatosis.
Authors: Earl TM, Nicoud IB, Pierce JM, Wright JP, Majoras NE, Rubin JE, Pierre KP, Gorden DL, Chari RS
Ann. Surg. Oncol., 2009;16(4):1043-50.
Species: Mouse
Sample Type: Serum

Hepatocyte-specific NEMO deletion promotes NK/NKT cell- and TRAIL-dependent liver damage.
Authors: Beraza N, Malato Y, Sander LE, Al-Masaoudi M, Freimuth J, Riethmacher D, Gores GJ, Roskams T, Liedtke C, Trautwein C
J. Exp. Med., 2009;206(8):1727-37.
Species: Mouse
Sample Type: Tissue Homogenates

Tumor necrosis factor-alpha and interleukin-1 antagonists alleviate inflammatory skin changes associated with epidermal growth factor receptor antibody therapy in mice.
Authors: Surguladze D, Deevi D, Claros N, Corcoran E, Wang S, Plym MJ, Wu Y, Doody J, Mauro DJ, Witte L, Busam KJ, Pytowski B, Rodeck U, Tonra JR
Cancer Res., 2009;69(14):5643-7.
Species: Mouse
Sample Type: Tissue Homogenates

Celastrol suppresses allergen-induced airway inflammation in a mouse allergic asthma model.
Authors: Kim DY, Park JW, Jeoung D, Ro JY
Eur. J. Pharmacol., 2009;612(1):98-105.
Species: Mouse
Sample Type: BALF

Targeting the chemotactic function of CD147 reduces collagen-induced arthritis.
Authors: Damsker JM, Okwumabua I, Pushkarsky T, Arora K, Bukrinsky MI, Constant SL
Immunology, 2009;126(1):55-62.
Species: Mouse
Sample Type: Tissue Homogenates

TLR9 agonist, but not TLR7/8, functions as an adjuvant to diminish FI-RSV vaccine-enhanced disease, while either agonist used as therapy during primary RSV infection increases disease severity.
Authors: Johnson TR, Rao S, Seder RA, Chen M, Graham BS
Vaccine, 2009;27(23):3045-52.
Species: Mouse
Sample Type: Cell Culture Supernates

TLR9 activation coupled to IL-10 deficiency induces adverse pregnancy outcomes.
Authors: Thaxton JE, Romero R, Sharma S
J. Immunol., 2009;183(2):1144-54.
Species: Mouse
Sample Type: Serum

Inhibitory effect of atractylenolide I on angiogenesis in chronic inflammation in vivo and in vitro.
Authors: Wang C, Duan H, He L
Eur. J. Pharmacol., 2009;612(1):143-52.
Species: Mouse
Sample Type: Air Pouch Exudate

Both FcgammaRIV and FcgammaRIII are essential receptors mediating type II and type III autoimmune responses via FcRgamma-LAT-dependent generation of C5a.
Authors: Syed SN, Konrad S, Wiege K, Nieswandt B, Nimmerjahn F, Schmidt RE, Gessner JE
Eur. J. Immunol., 2009;39(12):3343-56.
Species: Mouse
Sample Type: BALF

Anti-inflammatory effects of ethyl acetate fraction from Melilotus suaveolens Ledeb on LPS-stimulated RAW 264.7 cells.
Authors: Tao JY, Zheng GH, Zhao L, Wu JG, Zhang XY, Zhang SL, Huang ZJ, Xiong FL, Li CM
J Ethnopharmacol, 2009;123(1):97-105.
Species: Mouse
Sample Type: Cell Culture Supernates

Acute lung injury is reduced in fat-1 mice endogenously synthesizing n-3 fatty acids.
Authors: Mayer K, Kiessling A, Ott J, Schaefer MB, Hecker M, Henneke I, Schulz R, Gunther A, Wang J, Wu L, Roth J, Seeger W, Kang JX
Am. J. Respir. Crit. Care Med., 2009;179(6):474-83.
Species: Mouse
Sample Type: BALF

Vasoactive intestinal peptide attenuates concanavalin A-mediated liver injury.
Authors: Luo Q, Wang Y, Feng D, Xu Y, Xu L
Eur. J. Pharmacol., 2009;607(1):226-33.
Species: Mouse
Sample Type: Plasma

Combined inhibition of janus kinase 1/2 for the treatment of JAK2V617F-driven neoplasms: selective effects on mutant cells and improvements in measures of disease severity.
Authors: Liu PC, Caulder E, Li J, Waeltz P, Margulis A, Wynn R, Becker-Pasha M, Li Y, Crowgey E, Hollis G, Haley P, Sparks RB, Combs AP, Rodgers JD, Burn TC, Vaddi K, Fridman JS
Clin. Cancer Res., 2009;15(22):6891-900.
Species: Mouse
Sample Type: Plasma

An activating and inhibitory signal from an inhibitory receptor LMIR3/CLM-1: LMIR3 augments lipopolysaccharide response through association with FcRgamma in mast cells.
Authors: Izawa K, Kitaura J, Yamanishi Y, Matsuoka T, Kaitani A, Sugiuchi M, Takahashi M, Maehara A, Enomoto Y, Oki T, Takai T, Kitamura T
J. Immunol., 2009;183(2):925-36.
Species: Mouse
Sample Type: Cell Culture Supernates

Lipopolysaccharide triggered TNF-alpha-induced hepatocyte apoptosis in a murine non-alcoholic steatohepatitis model.
Authors: Kudo H, Takahara T, Yata Y, Kawai K, Zhang W, Sugiyama T
J. Hepatol., 2009;51(1):168-75.
Species: Mouse
Sample Type: Plasma

Thalidomide protects against ischemic neuronal damage induced by focal cerebral ischemia in mice.
Authors: Hyakkoku K, Nakajima Y, Izuta H, Shimazawa M, Yamamoto T, Shibata N, Hara H
Neuroscience, 2009;159(2):760-9.
Species: Mouse
Sample Type: Tissue Homogenates

Intravenous tolerance modulates macrophage classical activation and antigen presentation in experimental autoimmune encephalomyelitis.
Authors: Li H, Ciric B, Yang J, Xu H, Fitzgerald DC, Elbehi M, Fonseca-Kelly Z, Yu S, Zhang GX, Rostami A
J. Neuroimmunol., 2009;208(1):54-60.
Species: Mouse
Sample Type: Cell Culture Supernates

Selective triggering of apoptosis of concanavalin A-activated T cells by fraxinellone for the treatment of T-cell-dependent hepatitis in mice.
Authors: Sun Y, Qin Y, Gong FY, Wu XF, Hua ZC, Chen T, Xu Q
Biochem. Pharmacol., 2009;77(11):1717-24.
Species: Mouse
Sample Type: Serum

Stearoyl-CoA desaturase 1 deficiency protects mice from immune-mediated liver injury.
Authors: Feng D, Wang Y, Mei Y, Xu Y, Xu H, Lu Y, Luo Q, Zhou S, Kong X, Xu L
Lab. Invest., 2009;89(2):222-30.
Species: Mouse
Sample Type: Plasma

Plasminogen activator inhibitor-1 regulates neutrophil influx during acute pyelonephritis.
Authors: Roelofs JJ, Teske GJ, Bonta PI, de Vries CJ, Meijers JC, Weening JJ, van der Poll T, Florquin S
Kidney Int., 2009;75(1):52-9.
Species: Mouse
Sample Type: Tissue Homogenates

A MyD88-dependent early IL-17 production protects mice against airway infection with the obligate intracellular pathogen Chlamydia muridarum.
Authors: Zhang X, Gao L, Lei L, Zhong Y, Dube P, Berton MT, Arulanandam B, Zhang J, Zhong G
J. Immunol., 2009;183(2):1291-300.
Species: Mouse
Sample Type: BALF

A novel role for plasmin-mediated degradation of opsonizing antibody in the evasion of host immunity by virulent, but not attenuated, Francisella tularensis.
Authors: Crane DD, Warner SL, Bosio CM
J. Immunol., 2009;183(7):4593-600.
Species: Mouse
Sample Type: Cell Culture Supernates

Attenuation of AD-like neuropathology by harnessing peripheral immune cells: local elevation of IL-10 and MMP-9.
Authors: Koronyo-Hamaoui M, Ko MK, Koronyo Y, Azoulay D, Seksenyan A, Kunis G, Pham M, Bakhsheshian J, Rogeri P, Black KL, Farkas DL, Schwartz M
J. Neurochem., 2009;111(6):1409-24.
Species: Mouse
Sample Type: Tissue Homogenates

Hypoxia-inducible factor-dependent induction of netrin-1 dampens inflammation caused by hypoxia.
Authors: Rosenberger P, Schwab JM, Mirakaj V, Masekowsky E, Mager A, Morote-Garcia JC, Unertl K, Eltzschig HK
Nat. Immunol., 2009;10(2):195-202.
Species: Mouse
Sample Type: Serum

CCL2/MCP-1 controls parasite burden, cell infiltration, and mononuclear activation during acute Trypanosoma cruzi infection.
Authors: Paiva CN, Figueiredo RT, Kroll-Palhares K, Silva AA, Silverio JC, Gibaldi D, Pyrrho Ados S, Benjamim CF, Lannes-Vieira J, Bozza MT
J. Leukoc. Biol., 2009;86(5):1239-46.
Species: Mouse
Sample Type: Plasma

Ethyl pyruvate administration inhibits hepatic tumor growth.
Authors: Liang X, Chavez AR, Schapiro NE, Loughran P, Thorne SH, Amoscato AA, Zeh HJ, Beer-Stolz D, Lotze MT, de Vera ME
J. Leukoc. Biol., 2009;86(3):599-607.
Species: Mouse
Sample Type: Plasma

Syndecan-1 shedding facilitates the resolution of neutrophilic inflammation by removing sequestered CXC chemokines.
Authors: Hayashida K, Parks WC, Park PW
Blood, 2009;114(14):3033-43.
Species: Mouse
Sample Type: Serum

Reduction in dietary omega-6 polyunsaturated fatty acids: eicosapentaenoic acid plus docosahexaenoic acid ratio minimizes atherosclerotic lesion formation and inflammatory response in the LDL receptor null mouse.
Authors: Wang S, Wu D, Matthan NR, Lamon-Fava S, Lecker JL, Lichtenstein AH
Atherosclerosis, 2009;204(1):147-55.
Species: Mouse
Sample Type: Plasma

Secretory lysosome targeting and induced secretion of human soluble TNF-alpha receptor in murine hematopoietic cells in vivo as a principle for immunoregulation in inflammation and malignancy.
Authors: Johansson AC, Nandakumar KS, Persson AM, Olsson I, Hansson M
Exp. Hematol., 2009;37(8):969-78.
Species: Mouse
Sample Type: Cell Culture Supernates

Macrophage tumor necrosis factor-alpha induces epithelial expression of granulocyte-macrophage colony-stimulating factor: impact on alveolar epithelial repair.
Authors: Cakarova L, Marsh LM, Wilhelm J, Mayer K, Grimminger F, Seeger W, Lohmeyer J, Herold S
Am. J. Respir. Crit. Care Med., 2009;180(6):521-32.
Species: Mouse
Sample Type: Cell Culture Supernates

Dendritic cells derived from TBP-2-deficient mice are defective in inducing T cell responses.
Authors: Son A, Nakamura H, Okuyama H, Oka S, Yoshihara E, Liu W, Matsuo Y, Kondo N, Masutani H, Ishii Y, Iyoda T, Inaba K, Yodoi J
Eur. J. Immunol., 2008;38(5):1358-67.
Species: Mouse
Sample Type: Cell Culture Supernates

Hypoxia enhances lysosomal TNF-alpha degradation in mouse peritoneal macrophages.
Authors: Lahat N, Rahat MA, Kinarty A, Weiss-Cerem L, Pinchevski S, Bitterman H
Am. J. Physiol., Cell Physiol., 2008;295(1):C2-12.
Species: Mouse
Sample Type: Cell Culture Supernates

Antifibrotic action of pirfenidone and prednisolone: different effects on pulmonary cytokines and growth factors in bleomycin-induced murine pulmonary fibrosis.
Authors: Oku H, Shimizu T, Kawabata T, Nagira M, Hikita I, Ueyama A, Matsushima S, Torii M, Arimura A
Eur. J. Pharmacol., 2008;590(1):400-8.
Species: Mouse
Sample Type: Tissue Homogenates

NOD2-deficient mice have impaired resistance to Mycobacterium tuberculosis infection through defective innate and adaptive immunity.
Authors: Divangahi M, Mostowy S, Coulombe F, Kozak R, Guillot L, Veyrier F, Kobayashi KS, Flavell RA, Gros P, Behr MA
J. Immunol., 2008;181(10):7157-65.
Species: Mouse
Sample Type: Cell Culture Supernates

Functional roles for C5a receptors in sepsis.
Authors: Rittirsch D, Flierl MA, Nadeau BA, Day DE, Huber-Lang M, Mackay CR, Zetoune FS, Gerard NP, Cianflone K, Kohl J, Gerard C, Sarma JV, Ward PA
Nat. Med., 2008;14(5):551-7.
Species: Mouse
Sample Type: Plasma

Inflamed phenotype of the mesenteric microcirculation of melanocortin type 3 receptor-null mice after ischemia-reperfusion.
Authors: Leoni G, Patel HB, Sampaio AL, Gavins FN, Murray JF, Grieco P, Getting SJ, Perretti M
FASEB J., 2008;22(12):4228-38.
Species: Mouse
Sample Type: Plasma

Insulin-like growth factor-1 improves survival in sepsis via enhanced hepatic bacterial clearance.
Authors: Ashare A, Nymon AB, Doerschug KC, Morrison JM, Monick MM, Hunninghake GW
Am. J. Respir. Crit. Care Med., 2008;178(2):149-57.
Species: Mouse
Sample Type: Tissue Homogenates

TLR-2 and IL-17A in chitin-induced macrophage activation and acute inflammation.
Authors: Da Silva CA, Hartl D, Liu W, Lee CG, Elias JA
J. Immunol., 2008;181(6):4279-86.
Species: Mouse
Sample Type: BALF

Staphylococcus aureus infection after splenectomy and splenic autotransplantation in BALB/c mice.
Authors: Teixeira FM, Fernandes BF, Rezende AB, Machado RR, Alves CC, Perobelli SM, Nunes SI, Farias RE, Rodrigues MF, Ferreira AP, Oliveira SC, Teixeira HC
Clin. Exp. Immunol., 2008;154(2):255-63.
Species: Mouse
Sample Type: Cell Culture Supernates

A novel mechanism for CCR4 in the regulation of macrophage activation in bleomycin-induced pulmonary fibrosis.
Authors: Trujillo G, O'Connor EC, Kunkel SL, Hogaboam CM
Am. J. Pathol., 2008;172(5):1209-21.
Species: Mouse
Sample Type: Tissue Homogenates

Tranilast, an orally active anti-allergic drug, up-regulates the anti-inflammatory heme oxygenase-1 expression but down-regulates the pro-inflammatory cyclooxygenase-2 and inducible nitric oxide synthase expression in RAW264.7 macrophages.
Authors: Pae HO, Jeong SO, Koo BS, Ha HY, Lee KM, Chung HT
Biochem. Biophys. Res. Commun., 2008;371(3):361-5.
Species: Mouse
Sample Type: Cell Culture Supernates

Synthetic chemerin-derived peptides suppress inflammation through ChemR23.
Authors: Cash JL, Hart R, Russ A, Dixon JP, Colledge WH, Doran J, Hendrick AG, Carlton MB, Greaves DR
J. Exp. Med., 2008;205(4):767-75.
Species: Mouse
Sample Type: Peritoneal Fluid

The neuropeptide substance P is a critical mediator of burn-induced acute lung injury.
Authors: Sio SW, Puthia MK, Lu J, Moochhala S, Bhatia M
J. Immunol., 2008;180(12):8333-41.
Species: Mouse
Sample Type: Tissue Homogenates

Chemical sympathectomy increases susceptibility to ocular herpes simplex virus type 1 infection.
Authors: Templeton A, Nguyen G, Ash JD, Straub RH, Carr DJ
J. Neuroimmunol., 2008;197(1):37-46.
Species: Mouse
Sample Type: Tissue Homogenates

CT20126, a novel immunosuppressant, prevents collagen-induced arthritis through the down-regulation of inflammatory gene expression by inhibiting NF-kappaB activation.
Authors: Lee SJ, Nam WD, Na HJ, Cho YL, Ha KS, Hwang JY, Lee H, Kim SO, Kwon YG, Kim YM
Biochem. Pharmacol., 2008;76(1):79-90.
Species: Mouse
Sample Type: Cell Culture Supernates

The essential role of IFN-gamma in the control of lethal Aggregatibacter actinomycetemcomitans infection in mice.
Authors: Garlet GP, Cardoso CR, Campanelli AP, Garlet TP, Avila-Campos MJ, Cunha FQ, Silva JS
Microbes Infect., 2008;10(5):489-96.
Species: Mouse
Sample Type: Tissue Homogenates

Peroxisome proliferator-activated receptor-gamma ligand, 15-deoxy-Delta12,14-prostaglandin J2, reduces neutrophil migration via a nitric oxide pathway.
Authors: Napimoga MH, Vieira SM, Dal-Secco D, Freitas A, Souto FO, Mestriner FL, Alves-Filho JC, Grespan R, Kawai T, Ferreira SH, Cunha FQ
J. Immunol., 2008;180(1):609-17.
Species: Mouse
Sample Type: Peritoneal Exudate

Adverse functions of IL-17A in experimental sepsis.
Authors: Flierl MA, Rittirsch D, Gao H, Hoesel LM, Nadeau BA, Day DE, Zetoune FS, Sarma JV, Huber-Lang MS, Ferrara JL, Ward PA
FASEB J., 2008;22(7):2198-205.
Species: Mouse
Sample Type: Plasma

The function of TRADD in signaling through tumor necrosis factor receptor 1 and TRIF-dependent Toll-like receptors.
Authors: Pobezinskaya YL, Kim YS, Choksi S, Morgan MJ, Li T, Liu C, Liu Z
Nat. Immunol., 2008;9(9):1047-54.
Species: Mouse
Sample Type: Cell Culture Supernates

Role of the chemokine decoy receptor D6 in balancing inflammation, immune activation, and antimicrobial resistance in Mycobacterium tuberculosis infection.
Authors: Di Liberto D, Locati M, Caccamo N, Vecchi A, Meraviglia S, Salerno A, Sireci G, Nebuloni M, Caceres N, Cardona PJ, Dieli F, Mantovani A
J. Exp. Med., 2008;205(9):2075-84.
Species: Mouse
Sample Type: Serum

Pharmacological IKK2 inhibition blocks liver steatosis and initiation of non-alcoholic steatohepatitis.
Authors: Beraza N, Malato Y, Vander Borght S, Liedtke C, Wasmuth HE, Dreano M, De Vos R, Roskams T, Trautwein C
Gut, 2008;57(5):655-63.
Species: Mouse
Sample Type: Tissue Homogenates

Suppression of activation and induction of apoptosis in RAW264.7 cells by amniotic membrane extract.
Authors: He H, Li W, Chen SY, Zhang S, Chen YT, Hayashida Y, Zhu YT, Tseng SC
Invest. Ophthalmol. Vis. Sci., 2008;49(10):4468-75.
Species: Mouse
Sample Type: Cell Culture Supernates

Endogenous hydrogen sulfide regulates inflammatory response by activating the ERK pathway in polymicrobial sepsis.
Authors: Zhang H, Moochhala SM, Bhatia M
J. Immunol., 2008;181(6):4320-31.
Species: Mouse
Sample Type: Tissue Homogenates

Novel immunomodulatory properties of berbamine through selective down-regulation of STAT4 and action of IFN-gamma in experimental autoimmune encephalomyelitis.
Authors: Ren Y, Lu L, Guo TB, Qiu J, Yang Y, Liu A, Zhang JZ
J. Immunol.

生物活性 < 0.5% cross-reactivity observed with available related molecules.< 50% cross-species reactivity observed with species tested.
背景

Tumor necrosis factor alpha (TNF-α), also known as cachectin and TNFSF2, is the prototypic ligand of the TNF superfamily. It is a pleiotropic molecule that plays a central role in inflammation, apoptosis, and immune system development. TNF-α is produced by a wide variety of immune and epithelial cell types. Human TNF-α consists of a 35 amino acid (aa) cytoplasmic domain, a 21 aa transmembrane segment, and a 177 aa extracellular domain (ECD). Within the ECD, human TNF-α shares 97% aa sequence identity with rhesus and 71% - 92% with bovine, canine, cotton rat, equine, feline, mouse, porcine, and rat TNF-α. The 26 kDa type 2 transmembrane protein is assembled intracellularly to form a noncovalently linked homotrimer. Ligation of this complex induces reverse signaling that promotes lymphocyte costimulation but diminishes monocyte responsiveness.

Cleavage of membrane bound TNF-α by TACE/ADAM17 releases a 55 kDa soluble trimeric form of TNF-α. TNF-α trimers bind the ubiquitous TNF RI and the hematopoietic cell-restricted TNF RII, both of which are also expressed as homotrimers. TNF-α regulates lymphoid tissue development through control of apoptosis. It also promotes inflammatory responses by inducing the activation of vascular endothelial cells and macrophages. TNF-α is a key cytokine in the development of several inflammatory disorders. It contributes to the development of type 2 diabetes through its effects on insulin resistance and fatty acid metabolism.

参考文献
  • Adipocytokines
  • Cancer Biomarkers
  • Conventional/Classical Dendritic Cells
  • Co-stimulatory and Co-inhibitory Molecules
  • Cytokines and Receptors in Allergy and Asthma
  • Cytokines and Receptors in Angiogenesis
  • Cytokines in Lipid/Cholesterol Metabolism
  • Diabetes
  • Diabetic Peripheral Neuropathy
  • EMT Induction
  • gamma delta T Cells
  • ICC / IHC Images: TNF-alpha
  • Inflammatory Mediators
  • Inflammatory/Monocyte-derived Dendritic Cells
  • Interactive Pathway: Adipocytokines & Insulin Signaling
  • Isolation, Culture, and Identification of Natural Killer Cells
  • Macrophage Activation Markers
  • Natural Killer T (NKT) Cells
  • Neuroinflammation
  • Obesity
  • Plasmacytoid Dendritic Cells
  • Preeclampsia
  • Regulation of Apoptosis by TNF Superfamily Members
  • Regulation of Natural Killer Cell Co-stimulation by TNF Superfamily Members
  • Regulation of T Cell Co-stimulation by TNF Superfamily Members
  • T Cell Cytokine Signaling
  • Technical Notes: R&D Systems Is With You Every Step of the Way - Analyzing Proteins of Interest
  • Th1 Cells
  • Th22 Cells
  • TNF Superfamily Ligands
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很高兴您选择优宁维进行科研服务,为了保障我们双方的共同利益,精诚良好的合作,避免产生不必要的责任纠纷,请您认真阅读以下内容并配合我们事宜,若您同意以下内容,请点击同意,进入网站下单界面。

1.为保证数据质量,您需严格按要求准备样本和试剂:

1)血清、血浆、尿液、灌洗液、组织、细胞沉淀、裂解蛋白等,未经过反复冻融,且用量满足实验要求的最低标准。

2)组化实验组织样本,需经过10%中性缓冲福尔马林固定24-72小时后,转移到75%酒精中送样,且保证样品管上标记清晰,不会被酒精渗漏模糊掉字迹。

3)组化实验蜡块和切片样本,常温运输,尽可能使用盒子装蜡块,避免互相之前摩擦影响样本;切片使用切片盒放置,避免玻片之间相关刮创。

4)您必须明确说明提供给乙方的实验材料的安全性,确保无致病性、无传染性,对人、动植物和环境友好安全,以保证实验技术人员的安全。

5)珍贵样本,请您只提供满足实验服务合同的所需量,剩余样本自己保存好以免造成样本的浪费,耽误您的实验进展。

6)甲方任何样本准备过程中的疑问,均可以咨询乙方。或者发邮件至labex@univ-bio.com,或者拨打4008-168-068转3。

2.为保证实验准确性,您需知悉以下内容:

1)非试剂盒验证样本,存在检出率低的风险,客户知晓并同意的情况下,Labex配合开展实验。

2)检出率是在MSD标准曲线范围内的数据,样本内因子含量超出标准品检测范围的情况下:若低于MSD标准曲线范围,则无法检出;若超过标准品检测上限,需实进一步稀释样本优化实验。MSD技术是目前市场上检测范围最宽(横跨4-5log)的多因子检测技术,但蛋白质组几万种蛋白浓度横跨10 log,不能一概而论。

3.实验服务过程中样本和试剂运输要求:

1)您可自行送样(方式包括快递以及亲送)到我们指定地点,但过程中要保证正确的运输条件,干冰货物或冰袋运输务必保证干冰充足和冰袋低温。并及时通知到我们,方便我们接收。

您还需要准备一份随样单(合同附件所示),标注您的姓名、合同号、样本信息、试剂信息,随快递一起寄送。

若由于您运输条件的原因,导致实验结果问题,相关责任由您承担。

实验室接收样本联系方式,提供寄送咨询: labex@univ-bio.com4008-168-0683

2)若您需要我们协助寄送样本时,我们会收取合理的寄送费用,以我们标准合同上所列收费为准。

4.实验服务合同结束后样本和试剂处置须知:

请您下单前确定实验服务合同结束后,样本处置情况。我们将严格按照合同约定执行。若您选择实验结束后样本,不保留,丢弃,我们会在实验结束后按国家标准自行处置掉相关实验材料。若您需要回寄相关样本,在您支付一定的运输费用后,我们将剩余样本在规定时间内返还给您。若您选择到付,需要保证您的样本是常温和蓝冰运输的,更高要求的运输条件不支持货到付款。若您不确定是否回寄,我们将保持您的样本1个月的时间,如超期,样本我们将自行处置,不在另行通知您。 如果您选择我们回寄样本给您,我们将快递信息邮件告知您,由您跟踪物流信息,并及时确认。如因您个人原因或者第三方物流原因造成的样本邮寄过程中的损耗,我们不承担任何责任。

5.实验服务种实验服务数据:

1) 我们承诺按照《实验样本信息及要求》中的实验方案进行实验并提供客观实验结果,但由于科研实验中存在诸多不确定因素以及未知难度和风险而导致结果的不确定性,不能保证所有的实验进度和实验结果完全达到甲方预期。在排除实验操作问题导致不良结果的前提下,您应尊重客观事实,承担实验结果与预期不一致的结果,包括实验结果是阴性的风险。因此在得不到预期结果的情况下,您仍应支付本次实验服务的全部已发生费用。

2) 实验服务是由专业技术达标的实验人员,遵循科学实验方法和标准操作流程,依照服务合同完成,优宁维保证将客观真实科学严谨的实验结果给到客户,但单次实验不足以阐明某些复杂的科学问题。

3) 您在收到实验数据后,5个工作日内(荧光相关实验3个工作日内)对实验数据质量提质疑,我们有义务解答。若是我们实验过程中的问题,我们承担全部责任;若是您验设计问题,您承担全部责任。我们承诺1个月的数据复核期,欢迎后续咨询。

6.客户知识产权保密协议:

1) 实验服务过程中产生的实验数据的知识产权归您所有,我们承诺不得以任何形式向除甲方以外的第三方提供该实验数据。对于相关的实验技术所有权归我们所有,您不得主张权利。

2) 我们双方共同致力于维护对方的商业机密和技术机密,包括本次合同所签订的文件,您都有义务进行保密。

7.服务承诺

如由于实验客观性需要重复实验、自然灾害、政府行为或其他乙方无法预见、无法避免和无法克服等不可抗力的客观原因造成合同无法按期履行的,我们将及时通知甲方,双方将视情况决定是否继续履行合同。如果由于客观原因造成某些实验项目不能执行的,合同结束时,退回相应款项。

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