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Mouse IL-1 beta/IL-1F2 Quantikine ELISA Kit, 2 Plate

(MLB00C)



概述
货号 MLB00C
描述

The Quantikine Mouse IL-1 beta Immunoassay is a 4.5 hour solid phase ELISA designed to measure mouse IL-1 beta in cell culture supernates, cell lysates, serum, and plasma. It contains E. coli-expressed recombinant mouse IL-1 beta and antibodies raised against the recombinant factor. This immunoassay has been shown to quantitate the recombinant factor accurately. Results obtained using natural mouse IL-1 beta showed dose-response curves that were parallel to the standard curves obtained using the recombinant kit standards. These results indicate that this kit can be used to determine relative mass values for natural mouse IL-1 beta.

别名 catabolin; IL-1 beta; IL-1; IL1B; IL-1B; IL1-BETA; IL-1F2; IL1F2IL-1 beta; interleukin 1, beta; interleukin-1 beta; preinterleukin 1 beta; pro-interleukin-1-beta;
全称
Interleukin 1 beta
反应种属 Mouse
目标/特异性 Natural and recombinant mouse IL-1 beta
性能
供应商 R&D Systems
Entrez Gene IDs
3553 (Human); 16176 (Mouse); 24494 (Rat); 397122 (Porcine); 403974 (Canine); 100034237 (Equine); 100135556 (Guinea Pig)
应用文献
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

A Critical Role for P2X7 Receptor-Induced VCAM-1 Shedding and Neutrophil Infiltration during Acute Lung Injury
J Immunol, 2016;0(0):.

DNMT1-PPAR? pathway in macrophages regulates chronic inflammation and atherosclerosis development in mice
Sci Rep, 2016;6(0):30053.
Species: Mouse
Sample Type: Plasma

Toll-Like Receptor 4 Signaling Pathway Mediates Inhalant Organic Dust-Induced Bone Loss
PLoS ONE, 2016;11(8):e0158735.
Species: Mouse
Sample Type: BALF

Neutrophils suppress intraluminal NK-mediated tumor cell clearance and enhance extravasation of disseminated carcinoma cells
Authors: A Spiegel, MW Brooks, S Houshyar, F Reinhardt, M Ardolino, E Fessler, MB Chen, JA Krall, J DeCock, IK Zervantona, A Iannello, Y Iwamoto, V Cortez-Ret, RD Kamm, MJ Pittet, DH Raulet, RA Weinberg
Cancer Discov, 2016;0(0):.
Species: Mouse
Sample Type: Cell Culture Supernates

Kruppel-like factor 6 promotes macrophage-mediated inflammation by suppressing B cell leukemia/lymphoma 6 expression
J Biol Chem, 2016;0(0):.
Species: Mouse
Sample Type: Tissue Homogenates

Pyrin inflammasome activation and RhoA signaling in the autoinflammatory diseases FMF and HIDS
Authors: Yong Hwan Park
Nat Immunol, 2016;0(0):.
Species: Mouse
Sample Type: Cell Culture Supernates

Pycnogenol Attenuates the Release of Proinflammatory Cytokines and Expression of Perilipin 2 in Lipopolysaccharide-Stimulated Microglia in Part via Inhibition of NF-kappaB and AP-1 Activation.
Authors: Fan B, Dun S, Gu J, Guo Y, Ikuyama S
PLoS ONE, 2015;10(9):e0137837.
Species: Mouse
Sample Type: Cell Culture Supernates

Accelerated tumor progression in mice lacking the ATP receptor P2X7.
Authors: Adinolfi E, Capece M, Franceschini A, Falzoni S, Giuliani A, Rotondo A, Sarti A, Bonora M, Syberg S, Corigliano D, Pinton P, Jorgensen N, Abelli L, Emionite L, Raffaghello L, Pistoia V, Di Virgilio F
Cancer Res, 2015;75(4):635-44.
Species: Mouse
Sample Type: Plasma

Chronic morphine-induced microRNA-124 promotes microglial immunosuppression by modulating P65 and TRAF6.
Authors: Qiu S, Feng Y, LeSage G, Zhang Y, Stuart C, He L, Li Y, Caudle Y, Peng Y, Yin D
J Immunol, 2015;194(3):1021-30.
Species: Mouse
Sample Type: Cell Culture Supernates

RIP3-mediated necrotic cell death accelerates systematic inflammation and mortality.
Authors: Meng L, Jin W, Wang X
Proc Natl Acad Sci U S A, 2015;112(35):11007-12.
Species: Mouse
Sample Type: Cell Culture Supernates

Sevoflurane inhibits nuclear factor-kappaB activation in lipopolysaccharide-induced acute inflammatory lung injury via toll-like receptor 4 signaling.
Authors: Sun X, Li X, Wang X, Tan W, Wang J
PLoS ONE, 2015;10(4):e0122752.
Species: Mouse
Sample Type: BALF

Critical role for IL-18 in spontaneous lung inflammation caused by autophagy deficiency.
Authors: Abdel Fattah E, Bhattacharya A, Herron A, Safdar Z, Eissa N
J Immunol, 2015;194(11):5407-16.

Microglial Heparan Sulfate Proteoglycans Facilitate the Cluster-of-Differentiation 14 (CD14)/Toll-like Receptor 4 (TLR4)-Dependent Inflammatory Response.
Authors: O'Callaghan P, Li J, Lannfelt L, Lindahl U, Zhang X
J Biol Chem, 2015;290(24):14904-14.
Species: Mouse
Sample Type: Cell Culture Supernates

Novel Noncompetitive IL-1 Receptor-Biased Ligand Prevents Infection- and Inflammation-Induced Preterm Birth.
Authors: Nadeau-Vallee M, Quiniou C, Palacios J, Hou X, Erfani A, Madaan A, Sanchez M, Leimert K, Boudreault A, Duhamel F, Rivera J, Zhu T, Noueihed B, Robertson S, Ni X, Olson D, Lubell W, Girard S, Chemtob S
J Immunol, 2015;195(7):3402-15.
Species: Mouse
Sample Type: Plasma

Sharpin Controls Osteogenic Differentiation of Mesenchymal Bone Marrow Cells.
Authors: Jeschke A, Catala-Lehnen P, Sieber S, Bickert T, Schweizer M, Koehne T, Wintges K, Marshall R, Mautner A, Duchstein L, Otto B, Horst A, Amling M, Kreienkamp H, Schinke T
J Immunol, 2015;195(8):3675-84.
Species: Mouse
Sample Type: Serum

CCL3 production by microglial cells modulates disease severity in murine models of retinal degeneration.
Authors: Kohno H, Maeda T, Perusek L, Pearlman E, Maeda A
J Immunol, 2014;192(8):3816-27.
Species: Mouse
Sample Type: tissue homogenate

Neurodegeneration by activation of the microglial complement-phagosome pathway.
Authors: Bodea L, Wang Y, Linnartz-Gerlach B, Kopatz J, Sinkkonen L, Musgrove R, Kaoma T, Muller A, Vallar L, Di Monte D, Balling R, Neumann H
J Neurosci, 2014;34(25):8546-56.
Species: Mouse
Sample Type: Plasma

Akt2 deficiency protects from acute lung injury via alternative macrophage activation and miR-146a induction in mice.
Authors: Vergadi, Eleni, Vaporidi, Katerina, Theodorakis, Emmanuel, Doxaki, Christin, Lagoudaki, Eleni, Ieronymaki, Elefther, Alexaki, Vassilia, Helms, Mike, Kondili, Eumorfia, Soennichsen, Birte, Stathopoulos, Efstathi, Margioris, Andrew N, Georgopoulos, Dimitrio, Tsatsanis, Christos
J Immunol, 2014;192(1):394-406.
Species: Mouse
Sample Type: BALF

Spironolactone attenuates bleomycin-induced pulmonary injury partially via modulating mononuclear phagocyte phenotype switching in circulating and alveolar compartments.
Authors: Ji W, Ma Y, Zhou X, Zhang Y, Lu R, Guo Z, Sun H, Hu D, Yang G, Li Y, Wei L
PLoS ONE, 2013;8(11):e81090.
Species: Mouse
Sample Type: BALF

Impaired bone formation and increased osteoclastogenesis in mice lacking chemokine (C-C motif) ligand 5 (Ccl5).
Authors: Wintges K, Beil F, Albers J, Jeschke A, Schweizer M, Claass B, Tiegs G, Amling M, Schinke T
J Bone Miner Res, 2013;28(10):2070-80.
Species: Mouse
Sample Type: Cell Culture Supernates

Bcl-2 overexpression ameliorates immune complex-mediated arthritis by altering FcgammaRIIb expression and monocyte homeostasis.
Authors: Lawlor K, van Nieuwenhuijze A, Parker K, Drake S, Campbell I, Smith S, Vince J, Strasser A, Wicks I
J Leukoc Biol, 2013;93(4):585-97.
Species: Mouse
Sample Type: Cell culture supernatant

CXCL6 antibody neutralization prevents lung inflammation and fibrosis in mice in the bleomycin model.
Authors: Besnard A, Struyf S, Guabiraba R, Fauconnier L, Rouxel N, Proost P, Uyttenhove C, Van Snick J, Couillin I, Ryffel B
J Leukoc Biol, 2013;94(6):1317-23.
Species: Mouse
Sample Type: Tissue Homogenates

mTORC1 and mTORC2 play different roles in the functional survival of transplanted adipose-derived stromal cells in hind limb ischemic mice via regulating inflammation in vivo.
Authors: Fan W, Cheng K, Qin X, Narsinh K, Wang S, Hu S, Wang Y, Chen Y, Wu J, Xiong L, Cao F
Stem Cells, 2013;31(1):203-14.
Species: Mouse
Sample Type: Tissue Lysate

NLRP3 is activated in Alzheimer's disease and contributes to pathology in APP/PS1 mice.
Authors: Heneka M, Kummer M, Stutz A, Delekate A, Schwartz S, Vieira-Saecker A, Griep A, Axt D, Remus A, Tzeng T, Gelpi E, Halle A, Korte M, Latz E, Golenbock D
Nature, 2013;493(7434):674-8.
Species: Mouse
Sample Type: Tissue Homogenates

Sirt2 suppresses inflammatory responses in collagen-induced arthritis.
Authors: Lin J, Sun B, Jiang C, Hong H, Zheng Y
Biochem Biophys Res Commun, 2013;441(4):897-903.
Species: Mouse
Sample Type: Serum

Staphylococcus aureus sarA regulates inflammation and colonization during central nervous system biofilm formation.
Authors: Snowden J, Beaver M, Beenken K, Smeltzer M, Horswill A, Kielian T
PLoS ONE, 2013;8(12):e84089.
Species: Mouse
Sample Type: Homogenized Tissue

A hydrogen sulfide-releasing cyclooxygenase inhibitor markedly accelerates recovery from experimental spinal cord injury.
Authors: Campolo M, Esposito E, Ahmad A, Di Paola R, Wallace J, Cuzzocrea S
FASEB J, 2013;27(11):4489-99.
Species: Mouse
Sample Type: Whole Tissue

Netrin-1 protects against L-Arginine-induced acute pancreatitis in mice.
Authors: Chen J, Cai Q, Shen P, Yan R, Wang C, Yang D, Fu H, Chen X
PLoS ONE, 2012;7(9):e46201.
Species: Mouse
Sample Type: Plasma

The axonal guidance receptor neogenin promotes acute inflammation.
Authors: Konig K, Gatidou D, Granja T, Meier J, Rosenberger P, Mirakaj V
PLoS ONE, 2012;7(3):e32145.
Species: Mouse
Sample Type: Peritoneal Lavage

Inhibiting Mer receptor tyrosine kinase suppresses STAT1, SOCS1/3, and NF-kappaB activation and enhances inflammatory responses in lipopolysaccharide-induced acute lung injury.
J. Cell. Sci., 2012;91(6):921-32.
Species: Mouse
Sample Type: BALF

Activated protein C inhibits pancreatic islet inflammation, stimulates T regulatory cells, and prevents diabetes in non-obese diabetic (NOD) mice.
Authors: Xue M, Dervish S, Harrison LC, Fulcher G, Jackson CJ
J. Biol. Chem., 2012;287(20):16356-64.
Species: Mouse
Sample Type: Cell Culture Supernates

Toll-like receptor-mediated inhibition of Gas6 and ProS expression facilitates inflammatory cytokine production in mouse macrophages.
Authors: Deng T, Zhang Y, Chen Q, Yan K, Han D
Immunology, 2012;135(1):40-50.
Species: Mouse
Sample Type: Cell Culture Supernates

Exendin-4 protected against cognitive dysfunction in hyperglycemic mice receiving an intrahippocampal lipopolysaccharide injection.
Authors: Huang H, Chen Y, Liang K, Jheng Y, Jhao J, Su M, Lee-Chen G, Hsieh-Li H
PLoS ONE, 2012;7(7):e39656.
Species: Mouse
Sample Type: Plasma

Modelling of mouse experimental colitis by global property screens: a holistic approach to assess drug effects in inflammatory bowel disease.
Authors: Gottfries J, Melgar S, Michaelsson E
PLoS ONE, 2012;7(1):e30005.
Species: Mouse
Sample Type: Tissue Homogenates

Treatment of diabetic mice with undenatured whey protein accelerates the wound healing process by enhancing the expression of MIP-1alpha, MIP-2, KC, CX3CL1 and TGF-beta in wounded tissue.
BMC Immunol., 2012;13(0):32.
Species: Mouse
Sample Type: Tissue Homogenates

Dual functions of prostaglandin D2 in murine contact hypersensitivity via DP and CRTH2.
Authors: Yamamoto Y, Otani S, Hirai H, Nagata K, Aritake K, Urade Y, Narumiya S, Yokozeki H, Nakamura M, Satoh T
Am. J. Pathol., 2012;179(1):302-14.
Species: Mouse
Sample Type: Tissue Homogenates

Caspase-11 increases susceptibility to Salmonella infection in the absence of caspase-1.
Authors: Broz P, Ruby T, Belhocine K, Bouley D, Kayagaki N, Dixit V, Monack D
Nature, 2012;490(7419):288-91.
Species: Mouse
Sample Type: Cell Culture Supernates

Chemotherapy-triggered cathepsin B release in myeloid-derived suppressor cells activates the Nlrp3 inflammasome and promotes tumor growth.
Authors: Bruchard M, Mignot G, Derangere V, Chalmin F, Chevriaux A, Vegran F, Boireau W, Simon B, Ryffel B, Connat J, Kanellopoulos J, Martin F, Rebe C, Apetoh L, Ghiringhelli F
Nat Med, 2012;19(1):57-64.
Species: Mouse
Sample Type: Cell Culture Supernates

Transgenic expression of human cathepsin B promotes progression and metastasis of polyoma-middle-T-induced breast cancer in mice.
Authors: Sevenich L, Werner F, Gajda M, Schurigt U, Sieber C, Muller S, Follo M, Peters C, Reinheckel T
Oncogene, 2011;30(1):54-64.
Species: Mouse
Sample Type: Tissue Homogenates

IL-33-activated dendritic cells are critical for allergic airway inflammation.
Authors: Besnard AG, Togbe D, Guillou N, Erard F, Quesniaux V, Ryffel B
Eur. J. Immunol., 2011;41(6):1675-86.
Species: Mouse
Sample Type: BALF

WNT5A Signaling Contributes to Abeta-Induced Neuroinflammation and Neurotoxicity.
Authors: Li B, Zhong L, Yang X, Andersson T, Huang M, Tang SJ
PLoS ONE, 2011;6(8):e22920.
Species: Mouse
Sample Type: Cell Culture Supernates

TLR4 through IFN-beta promotes low molecular mass hyaluronan-induced neutrophil apoptosis.
Authors: Leu SW, Shi L, Xu C, Zhao Y, Liu B, Li Y, Shiedlin A, Xiang C, Shen H, Quinn DA, Hales CA, Zhao H
J. Immunol., 2011;186(1):556-62.
Species: Mouse
Sample Type: BALF

Role of IL-1alpha and the Nlrp3/caspase-1/IL-1beta axis in cigarette smoke-induced pulmonary inflammation and COPD.
Authors: Pauwels NS, Bracke KR, Dupont LL, Van Pottelberge GR, Provoost S, Vanden Berghe T, Vandenabeele P, Lambrecht BN, Joos GF, Brusselle GG
Eur. Respir. J., 2011;38(5):1019-28.
Species: Mouse
Sample Type: BALF

Histone Deacetylase Inhibitor LAQ824 Augments Inflammatory Responses in Macrophages through Transcriptional Regulation of IL-10.
Authors: Wang H, Cheng F
J. Immunol., 2011;186(0):3986.
Species: Mouse
Sample Type: Cell Culture Supernates

Anti-inflammatory role of microsomal prostaglandin E synthase-1 in a model of neuroinflammation.
Authors: Brenneis C, Coste O, Altenrath K, Angioni C, Schmidt H, Schuh CD, Zhang DD, Henke M, Weigert A, Brune B, Rubin B, Nusing R, Scholich K, Geisslinger G
J. Biol. Chem., 2011;286(3):2331-42.
Species: Mouse
Sample Type: Cell Culture Supernates

Sphingosine regulates the NLRP3-inflammasome and IL-1beta release from macrophages.
Authors: Luheshi NM, Giles JA, Lopez-Castejon G, Brough D
Eur. J. Immunol., 2011;42(3):716-25.
Species: Mouse
Sample Type: Cell Culture Supernates

Serotonin activates dendritic cell function in the context of gut inflammation.
Authors: Li N, Ghia JE, Wang H, McClemens J, Cote F, Suehiro Y, Mallet J, Khan WI
Am. J. Pathol., 2011;178(2):662-71.
Species: Mouse
Sample Type: Cell Culture Supernates

Deletion of tristetraprolin caused spontaneous reactive granulopoiesis by a non-cell-autonomous mechanism without disturbing long-term hematopoietic stem cell quiescence.
Authors: Kaplan IM, Morisot S, Heiser D, Cheng WC, Kim MJ, Civin CI
J. Immunol., 2011;186(5):2826-34.
Species: Mouse
Sample Type: Plasma

Aryl hydrocarbon receptor deficiency in T cells suppresses the development of collagen-induced arthritis.
Authors: Nakahama T, Kimura A, Nguyen NT, Chinen I, Hanieh H, Nohara K, Fujii-Kuriyama Y, Kishimoto T
Proc. Natl. Acad. Sci. U.S.A., 2011;108(34):14222-7.
Species: Mouse
Sample Type: Serum

Fasting induces an anti-inflammatory effect on the neuroimmune system which a high-fat diet prevents.
Authors: Lavin DN, Joesting JJ, Chiu GS, Moon ML, Meng J, Dilger RN, Freund GG
Obesity (Silver Spring), 2011;19(8):1586-94.
Species: Mouse
Sample Type: Serum

HIF-VEGF pathways are critical for chronic otitis media in Junbo and Jeff mouse mutants.
Authors: Cheeseman MT, Tyrer HE, Williams D, Hough TA, Pathak P, Romero MR, Hilton H, Bali S, Parker A, Vizor L, Purnell T, Vowell K, Wells S, Bhutta MF, Potter PK, Brown SD
PLoS Genet., 2011;7(10):e1002336.
Species: Mouse
Sample Type: Serum

Repulsive guidance molecule-A (RGM-A) inhibits leukocyte migration and mitigates inflammation.
Authors: Mirakaj V, Brown S, Laucher S, Steinl C, Klein G, Kohler D, Skutella T, Meisel C, Brommer B, Rosenberger P, Schwab JM
Proc. Natl. Acad. Sci. U.S.A., 2011;108(16):6555-60.
Species: Mouse
Sample Type: Peritoneal Lavage

Action at a distance: systemically administered adult stem/progenitor cells (MSCs) reduce inflammatory damage to the cornea without engraftment and primarily by secretion of TNF-alpha stimulated gene/protein 6.
Authors: Roddy GW, Oh JY, Lee RH, Bartosh TJ, Ylostalo J, Coble K, Rosa RH, Prockop DJ
Stem Cells, 2011;29(10):1572-9.
Species: Mouse
Sample Type: Tissue Homogenates

Crawling Phagocytes Recruited in the Brain Vasculature after Pertussis Toxin Exposure through IL6, ICAM1 and ITGalphaM.
Authors: Richard JF, Roy M, Audoy-Remus J, Tremblay P, Vallieres L
Brain Pathol., 2011;21(0):661.
Species: Mouse
Sample Type: Serum

Microbial exposure early in life regulates airway inflammation in mice after infection with Streptococcus pneumoniae with enhancement of local resistance.
Authors: Yasuda Y, Matsumura Y, Kasahara K, Ouji N, Sugiura S, Mikasa K, Kita E
Am. J. Physiol. Lung Cell Mol. Physiol., 2010;298(1):L67-78.
Species: Mouse
Sample Type: BALF

Evidence that intrathecal morphine-3-glucuronide may cause pain enhancement via toll-like receptor 4/MD-2 and interleukin-1beta.
Authors: Lewis SS, Hutchinson MR, Rezvani N, Loram LC, Zhang Y, Maier SF, Rice KC, Watkins LR
Neuroscience, 2010;165(2):569-83.
Species: Mouse
Sample Type: Cell Lysates

Systemic inflammation sensitizes the neonatal brain to excitotoxicity through a pro-/anti-inflammatory imbalance: key role of TNFalpha pathway and protection by etanercept.
Authors: Aden U, Favrais G, Plaisant F, Winerdal M, Felderhoff-Mueser U, Lampa J, Lelievre V, Gressens P
Brain Behav. Immun., 2010;24(5):747-58.
Species: Mouse
Sample Type: Tissue Homogenates

Cytotoxins of the human pathogen Aeromonas hydrophila trigger, via the NLRP3 inflammasome, caspase-1 activation in macrophages.
Authors: McCoy AJ, Koizumi Y, Toma C, Higa N, Dixit V, Taniguchi S, Tschopp J, Suzuki T
Eur. J. Immunol., 2010;40(10):2797-803.
Species: Mouse
Sample Type: Cell Culture Supernates

Loss of ability to self-heal malaria upon taurine transporter deletion.
Authors: Delic D, Warskulat U, Borsch E, Al-Qahtani S, Al-Quraishi S, Haussinger D, Wunderlich F
Infect. Immun., 2010;78(4):1642-9.
Species: Mouse
Sample Type: Serum

Galectin-3 contributes to neonatal hypoxic-ischemic brain injury.
Authors: Doverhag C, Hedtjarn M, Poirier F, Mallard C, Hagberg H, Karlsson A, Savman K
Neurobiol. Dis., 2010;38(1):36-46.
Species: Mouse
Sample Type: Tissue Homogenates

Early protection from burn-induced acute lung injury by deletion of preprotachykinin-A gene.
Authors: Sio SW, Moochhala S, Lu J
Am. J. Respir. Crit. Care Med., 2010;181(1):36-46.
Species: Mouse
Sample Type: Tissue Homogenates

TLR4 is a negative regulator in noninfectious lung inflammation.
Authors: Zhao H, Leu SW, Shi L, Dedaj R, Zhao G, Garg HG, Shen L, Lien E, Fitzgerald KA, Shiedlin A, Shen H, Quinn DA, Hales CA
J. Immunol., 2010;184(9):5308-14.
Species: Mouse
Sample Type: BALF

Absence or inhibition of matrix metalloproteinase-8 decreases ventilator-induced lung injury.
Authors: Albaiceta GM, Gutierrez-Fernandez A, Garcia-Prieto E, Puente XS, Parra D, Astudillo A, Campestre C, Cabrera S, Gonzalez-Lopez A, Fueyo A, Taboada F, Lopez-Otin C
Am. J. Respir. Cell Mol. Biol., 2010;43(5):555-63.
Species: Mouse
Sample Type: Tissue Homogenates

Epithelial overexpression of SOCS-3 in transgenic mice exacerbates wound inflammation in the presence of elevated TGF-beta1.
Authors: Linke A, Goren I, Bosl MR, Pfeilschifter J, Frank S
J. Invest. Dermatol., 2010;130(3):866-75.
Species: Mouse
Sample Type: Tissue Homogenates

Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1beta in type 2 diabetes.
Authors: Masters SL, Dunne A, Subramanian SL, Hull RL, Tannahill GM, Sharp FA, Becker C, Franchi L, Yoshihara E, Chen Z, Mullooly N, Mielke LA, Harris J, Coll RC, Mills KH, Mok KH, Newsholme P, Nunez G, Yodoi J, Kahn SE, Lavelle EC, O'Neill LA
Nat. Immunol., 2010;11(10):897-904.
Species: Mouse
Sample Type: Cell Culture Supernates

Tumor necrosis factor-alpha and interleukin-1 antagonists alleviate inflammatory skin changes associated with epidermal growth factor receptor antibody therapy in mice.
Authors: Surguladze D, Deevi D, Claros N, Corcoran E, Wang S, Plym MJ, Wu Y, Doody J, Mauro DJ, Witte L, Busam KJ, Pytowski B, Rodeck U, Tonra JR
Cancer Res., 2009;69(14):5643-7.
Species: Mouse
Sample Type: Tissue Homogenates

Secretory lysosome targeting and induced secretion of human soluble TNF-alpha receptor in murine hematopoietic cells in vivo as a principle for immunoregulation in inflammation and malignancy.
Authors: Johansson AC, Nandakumar KS, Persson AM, Olsson I, Hansson M
Exp. Hematol., 2009;37(8):969-78.
Species: Mouse
Sample Type: Cell Culture Supernates

VAMP8 is essential in anaphylatoxin-induced degranulation, TNF-alpha secretion, peritonitis, and systemic inflammation.
Authors: Pushparaj PN, Tay HK, Wang CC, Hong W, Melendez AJ
J. Immunol., 2009;183(2):1413-8.
Species: Mouse
Sample Type: Serum

A MyD88-dependent early IL-17 production protects mice against airway infection with the obligate intracellular pathogen Chlamydia muridarum.
Authors: Zhang X, Gao L, Lei L, Zhong Y, Dube P, Berton MT, Arulanandam B, Zhang J, Zhong G
J. Immunol., 2009;183(2):1291-300.
Species: Mouse
Sample Type: BALF

Inhibitory effect of atractylenolide I on angiogenesis in chronic inflammation in vivo and in vitro.
Authors: Wang C, Duan H, He L
Eur. J. Pharmacol., 2009;612(1):143-52.
Species: Mouse
Sample Type: Air Pouch Exudate

Complement C3a regulates late asthmatic response and airway hyperresponsiveness in mice.
Authors: Mizutani N, Nabe T, Yoshino S
J. Immunol., 2009;183(6):4039-46.
Species: Mouse
Sample Type: BALF

Plasminogen activator inhibitor-1 regulates neutrophil influx during acute pyelonephritis.
Authors: Roelofs JJ, Teske GJ, Bonta PI, de Vries CJ, Meijers JC, Weening JJ, van der Poll T, Florquin S
Kidney Int., 2009;75(1):52-9.
Species: Mouse
Sample Type: Tissue Homogenates

Interleukin-1beta and fibroblast growth factor receptor 1 cooperate to induce cyclooxygenase-2 during early mammary tumourigenesis.
Authors: Reed JR, Leon RP, Hall MK, Schwertfeger KL
Breast Cancer Res., 2009;11(2):R21.
Species: Mouse
Sample Type: Cell Culture Supernates

Anti-inflammatory effects of ethyl acetate fraction from Melilotus suaveolens Ledeb on LPS-stimulated RAW 264.7 cells.
Authors: Tao JY, Zheng GH, Zhao L, Wu JG, Zhang XY, Zhang SL, Huang ZJ, Xiong FL, Li CM
J Ethnopharmacol, 2009;123(1):97-105.
Species: Mouse
Sample Type: Cell Culture Supernates

p47phox deficiency induces macrophage dysfunction resulting in progressive crystalline macrophage pneumonia.
Authors: Liu Q, Cheng LI, Yi L, Zhu N, Wood A, Changpriroa CM, Ward JM, Jackson SH
Am. J. Pathol., 2009;174(1):153-63.
Species: Mouse
Sample Type: BALF

NOD1 expression in the eye and functional contribution to IL-1beta-dependent ocular inflammation in mice.
Authors: Rosenzweig HL, Galster KT, Planck SR, Rosenbaum JT
Invest. Ophthalmol. Vis. Sci., 2009;50(4):1746-53.
Species: Mouse
Sample Type: Cell Culture Supernates

Syndecan-1 shedding facilitates the resolution of neutrophilic inflammation by removing sequestered CXC chemokines.
Authors: Hayashida K, Parks WC, Park PW
Blood, 2009;114(14):3033-43.
Species: Mouse
Sample Type: Serum

Inhibition of monocyte-derived inflammatory cytokines by IL-25 occurs via p38 Map kinase-dependent induction of Socs-3.
Authors: Caruso R, Stolfi C, Sarra M, Rizzo A, Fantini MC, Pallone F, MacDonald TT, Monteleone G
Blood, 2009;113(15):3512-9.
Species: Mouse
Sample Type: Serum

Bbeta(15-42) protects against acid-induced acute lung injury and secondary pseudomonas pneumonia in vivo.
Authors: Matt U, Warszawska JM, Bauer M, Dietl W, Mesteri I, Doninger B, Haslinger I, Schabbauer G, Perkmann T, Binder CJ, Reingruber S, Petzelbauer P, Knapp S
Am. J. Respir. Crit. Care Med., 2009;180(12):1208-17.
Species: Mouse
Sample Type: BALF

T cells dampen innate immune responses through inhibition of NLRP1 and NLRP3 inflammasomes.
Authors: Guarda G, Dostert C, Staehli F, Cabalzar K, Castillo R, Tardivel A, Schneider P, Tschopp J
Nature, 2009;460(7252):269-73.
Species: Mouse
Sample Type: Cell Culture Supernates

Hypoxia-inducible factor-dependent induction of netrin-1 dampens inflammation caused by hypoxia.
Authors: Rosenberger P, Schwab JM, Mirakaj V, Masekowsky E, Mager A, Morote-Garcia JC, Unertl K, Eltzschig HK
Nat. Immunol., 2009;10(2):195-202.
Species: Mouse
Sample Type: Serum

Differential IL-23 requirement for IL-22 and IL-17A production during innate immunity against Salmonella enterica serovar Enteritidis.
Authors: Siegemund S, Schutze N, Schulz S, Wolk K, Nasilowska K, Straubinger RK, Sabat R, Alber G
Int. Immunol., 2009;21(5):555-65.
Species: Mouse
Sample Type: Cell Culture Supernates

C/EBPalpha is required for pulmonary cytoprotection during hyperoxia.
Authors: Xu Y, Saegusa C, Schehr A, Grant S, Whitsett JA, Ikegami M
Am. J. Physiol. Lung Cell Mol. Physiol., 2009;297(2):L286-98.
Species: Mouse
Sample Type: Tissue Homogenates

Intravenous tolerance modulates macrophage classical activation and antigen presentation in experimental autoimmune encephalomyelitis.
Authors: Li H, Ciric B, Yang J, Xu H, Fitzgerald DC, Elbehi M, Fonseca-Kelly Z, Yu S, Zhang GX, Rostami A
J. Neuroimmunol., 2009;208(1):54-60.
Species: Mouse
Sample Type: Cell Culture Supernates

A small molecule CRTH2 antagonist inhibits FITC-induced allergic cutaneous inflammation.
Authors: Boehme SA, Franz-Bacon K, Chen EP, Sasik R, Sprague LJ, Ly TW, Hardiman G, Bacon KB
Int. Immunol., 2009;21(1):81-93.
Species: Mouse
Sample Type: Tissue Homogenates

Chrysanthemum indicum Linne extract inhibits the inflammatory response by suppressing NF-kappaB and MAPKs activation in lipopolysaccharide-induced RAW 264.7 macrophages.
Authors: Cheon MS, Yoon T, Lee do Y, Choi G, Moon BC, Lee AY, Choo BK, Kim HK
J Ethnopharmacol, 2009;122(3):473-7.
Species: Mouse
Sample Type: Cell Culture Supernates

Endogenous hydrogen sulfide regulates inflammatory response by activating the ERK pathway in polymicrobial sepsis.
Authors: Zhang H, Moochhala SM, Bhatia M
J. Immunol., 2008;181(6):4320-31.
Species: Mouse
Sample Type: Tissue Homogenates

Tumor-infiltrating myeloid-derived suppressor cells are pleiotropic-inflamed monocytes/macrophages that bear M1- and M2-type characteristics.
Authors: Umemura N, Saio M, Suwa T, Kitoh Y, Bai J, Nonaka K, Ouyang GF, Okada M, Balazs M, Adany R, Shibata T, Takami T
J. Leukoc. Biol., 2008;83(5):1136-44.
Species: Mouse
Sample Type: Cell Culture Supernates

Activation of NOD2 in vivo induces IL-1beta production in the eye via caspase-1 but results in ocular inflammation independently of IL-1 signaling.
Authors: Rosenzweig HL, Martin TM, Planck SR, Galster K, Jann MM, Davey MP, Kobayashi K, Flavell RA, Rosenbaum JT
J. Leukoc. Biol., 2008;84(2):529-36.
Species: Mouse
Sample Type: Tissue Homogenates

The NALP3 inflammasome is involved in the innate immune response to amyloid-beta.
Authors: Halle A, Hornung V, Petzold GC, Stewart CR, Monks BG, Reinheckel T, Fitzgerald KA, Latz E, Moore KJ, Golenbock DT
Nat. Immunol., 2008;9(8):857-65.
Species: Mouse
Sample Type: Cell Culture Supernates

Adverse functions of IL-17A in experimental sepsis.
Authors: Flierl MA, Rittirsch D, Gao H, Hoesel LM, Nadeau BA, Day DE, Zetoune FS, Sarma JV, Huber-Lang MS, Ferrara JL, Ward PA
FASEB J., 2008;22(7):2198-205.
Species: Mouse
Sample Type: Plasma

Myeloid Src kinases regulate phagocytosis and oxidative burst in pneumococcal meningitis by activating NADPH oxidase.
Authors: Paul R, Obermaier B, Van Ziffle J, Angele B, Pfister HW, Lowell CA, Koedel U
J. Leukoc. Biol., 2008;84(4):1141-50.
Species: Mouse
Sample Type: Tissue Homogenates

Mouse models of rhinovirus-induced disease and exacerbation of allergic airway inflammation.
Authors: Bartlett NW, Walton RP, Edwards MR, Aniscenko J, Caramori G, Zhu J, Glanville N, Choy KJ, Jourdan P, Burnet J, Tuthill TJ, Pedrick MS, Hurle MJ, Plumpton C, Sharp NA, Bussell JN, Swallow DM, Schwarze J, Guy B, Almond JW, Jeffery PK, Lloyd CM, Papi A, Killington RA, Rowlands DJ, Blair ED, Clarke NJ, Johnston SL
Nat. Med., 2008;14(2):199-204.
Species: Mouse
Sample Type: BALF

Purine receptor antagonist modulates serology and affective behaviors in lupus-prone mice: evidence of autoimmune-induced pain?
Authors: Ballok DA, Sakic B
Brain Behav. Immun., 2008;0(0):.
Species: Mouse
Sample Type: Serum

The neuropeptide substance P is a critical mediator of burn-induced acute lung injury.
Authors: Sio SW, Puthia MK, Lu J, Moochhala S, Bhatia M
J. Immunol., 2008;180(12):8333-41.
Species: Mouse
Sample Type: Tissue Homogenates

Antifibrotic action of pirfenidone and prednisolone: different effects on pulmonary cytokines and growth factors in bleomycin-induced murine pulmonary fibrosis.
Authors: Oku H, Shimizu T, Kawabata T, Nagira M, Hikita I, Ueyama A, Matsushima S, Torii M, Arimura A
Eur. J. Pharmacol., 2008;590(1):400-8.
Species: Mouse
Sample Type: Tissue Homogenates

Peroxisome proliferator-activated receptor-gamma ligand, 15-deoxy-Delta12,14-prostaglandin J2, reduces neutrophil migration via a nitric oxide pathway.
Authors: Napimoga MH, Vieira SM, Dal-Secco D, Freitas A, Souto FO, Mestriner FL, Alves-Filho JC, Grespan R, Kawai T, Ferreira SH, Cunha FQ
J. Immunol., 2008;180(1):609-17.
Species: Mouse
Sample Type: Peritoneal Exudate

Tranilast, an orally active anti-allergic drug, up-regulates the anti-inflammatory heme oxygenase-1 expression but down-regulates the pro-inflammatory cyclooxygenase-2 and inducible nitric oxide synthase expression in RAW264.7 macrophages.
Authors: Pae HO, Jeong SO, Koo BS, Ha HY, Lee KM, Chung HT
Biochem. Biophys. Res. Commun., 2008;371(3):361-5.
Species: Mouse
Sample Type: Cell Culture Supernates

Pharmacological and genetic inhibition of NADPH oxidase does not reduce brain damage in different models of perinatal brain injury in newborn mice.
Authors: Doverhag C, Keller M, Karlsson A, Hedtjarn M, Nilsson U, Kapeller E, Sarkozy G, Klimaschewski L, Humpel C, Hagberg H, Simbruner G, Gressens P, Savman K
Neurobiol. Dis., 2008;31(1):133-44.
Species: Mouse
Sample Type: Tissue Homogenates

CT20126, a novel immunosuppressant, prevents collagen-induced arthritis through the down-regulation of inflammatory gene expression by inhibiting NF-kappaB activation.
Authors: Lee SJ, Nam WD, Na HJ, Cho YL, Ha KS, Hwang JY, Lee H, Kim SO, Kwon YG, Kim YM
Biochem. Pharmacol., 2008;76(1):79-90.
Species: Mouse
Sample Type: Cell Culture Supernates

Functional roles for C5a receptors in sepsis.
Authors: Rittirsch D, Flierl MA, Nadeau BA, Day DE, Huber-Lang M, Mackay CR, Zetoune FS, Gerard NP, Cianflone K, Kohl J, Gerard C, Sarma JV, Ward PA
Nat. Med., 2008;14(5):551-7.
Species: Mouse
Sample Type: Plasma

Inflamed phenotype of the mesenteric microcirculation of melanocortin type 3 receptor-null mice after ischemia-reperfusion.
Authors: Leoni G, Patel HB, Sampaio AL, Gavins FN, Murray JF, Grieco P, Getting SJ, Perretti M
FASEB J., 2008;22(12):4228-38.
Species: Mouse
Sample Type: Plasma

Toll-like receptor 4 mediates the early inflammatory response after cold ischemia/reperfusion.
Authors: Kaczorowski DJ, Nakao A, Mollen KP, Vallabhaneni R, Sugimoto R, Kohmoto J, Tobita K, Zuckerbraun BS, McCurry KR, Murase N, Billiar TR
Transplantation, 2007;84(10):1279-87.
Species: Mouse
Sample Type: Serum

Neuronal NF-kappaB influences thermoregulation and survival in a sepsis model.
Authors: Juttler E, Inta I, Eigler V, Herrmann O, Maegele I, Maser-Gluth C, Schwaninger M
J. Neuroimmunol., 2007;189(1):41-9.
Species: Mouse
Sample Type: Serum

Soluble vascular endothelial growth factor receptor-1 protects mice in sepsis.
Authors: Tsao PN, Chan FT, Wei SC, Hsieh WS, Chou HC, Su YN, Chen CY, Hsu WM, Hsieh FJ, Hsu SM
Crit. Care Med., 2007;35(8):1955-60.
Species: Mouse
Sample Type: Plasma

ST2 is essential for Th2 responsiveness and resistance to pseudomonas aeruginosa keratitis.
Authors: Huang X, Du W, Barrett RP, Hazlett LD
Invest. Ophthalmol. Vis. Sci., 2007;48(10):4626-33.
Species: Mouse
Sample Type: Tissue Homogenates

Interleukin-1beta is the primary initiator of pulmonary inflammation following liver injury in mice.
Authors: Glasgow SC, Ramachandran S, Blackwell TS, Mohanakumar T, Chapman WC
Am. J. Physiol. Lung Cell Mol. Physiol., 2007;293(2):L491-6.
Species: Mouse
Sample Type: Cell Culture Supernates

Mice lacking NKCC1 are protected from development of bacteremia and hypothermic sepsis secondary to bacterial pneumonia.
Authors: Nguyen M, Pace AJ, Koller BH
J. Exp. Med., 2007;204(6):1383-93.
Species: Mouse
Sample Type: Tissue Homogenates

Mrp8 and Mrp14 are endogenous activators of Toll-like receptor 4, promoting lethal, endotoxin-induced shock.
Authors: Vogl T, Tenbrock K, Ludwig S, Leukert N, Ehrhardt C, van Zoelen MA, Nacken W, Foell D, van der Poll T, Sorg C, Roth J
Nat. Med., 2007;13(9):1042-9.
Species: Mouse
Sample Type: Serum

Maternal immune activation alters fetal brain development through interleukin-6.
Authors: Smith SE, Li J, Garbett K, Mirnics K, Patterson PH
J. Neurosci., 2007;27(40):10695-702.
Species: Mouse
Sample Type: Serum

The immunomodulation of endotoxin-induced acute lung injury by hesperidin in vivo and in vitro.
Authors: Yeh CC, Kao SJ, Lin CC, Wang SD, Liu CJ, Kao ST
Life Sci., 2007;80(20):1821-31.
Species: Mouse
Sample Type: BALF

Astragali Radix elicits anti-inflammation via activation of MKP-1, concomitant with attenuation of p38 and Erk.
Authors: Ryu M, Kim EH, Chun M, Kang S, Shim B, Yu YB, Jeong G, Lee JS
J Ethnopharmacol, 2007;115(2):184-93.
Species: Mouse
Sample Type: Air Pouch Exudate

Identification of an immune-responsive mesolimbocortical serotonergic system: potential role in regulation of emotional behavior.
Authors: Lowry CA, Hollis JH, de Vries A, Pan B, Brunet LR, Hunt JR, Paton JF, van Kampen E, Knight DM, Evans AK, Rook GA, Lightman SL
Neuroscience, 2007;146(2):756-72.
Species: Mouse
Sample Type: Plasma

Acute brain injury triggers MyD88-dependent, TLR2/4-independent inflammatory responses.
Authors: Koedel U, Merbt UM, Schmidt C, Angele B, Popp B, Wagner H, Pfister HW, Kirschning CJ
Am. J. Pathol., 2007;171(1):200-13.
Species: Mouse
Sample Type: Tissue Homogenates

The direct action of 1alpha,25(OH)2-vitamin D3 on purified mouse Langerhans cells.
Authors: Fujita H, Asahina A, Komine M, Tamaki K
Cell. Immunol., 2007;245(2):70-9.
Species: Mouse
Sample Type: Cell Culture Supernates

Cell-based angiopoietin-1 gene therapy for acute lung injury.
Authors: McCarter SD, Mei SH, Lai PF, Zhang QW, Parker CH, Suen RS, Hood RD, Zhao YD, Deng Y, Han RN, Dumont DJ, Stewart DJ
Am. J. Respir. Crit. Care Med., 2007;175(10):1014-26.
Species: Mouse
Sample Type: BALF

Cathelicidin-deficient (Cnlp -/- ) mice show increased susceptibility to Pseudomonas aeruginosa keratitis.
Authors: Huang LC, Reins RY, Gallo RL, McDermott AM
Invest. Ophthalmol. Vis. Sci., 2007;48(10):4498-508.
Species: Mouse
Sample Type: Tissue Homogenates

Toll-like receptor 4 (TLR4)-dependent proinflammatory and immunomodulatory properties of the glycoinositolphospholipid (GIPL) from Trypanosoma cruzi.
Authors: Medeiros MM, Peixoto JR, Oliveira AC, Cardilo-Reis L, Koatz VL, Van Kaer L, Previato JO, Mendonca-Previato L, Nobrega A, Bellio M
J. Leukoc. Biol., 2007;82(3):488-96.
Species: Mouse
Sample Type: Peritoneal Fluid

The flavonoid baicalin protects against cerebrovascular dysfunction and brain inflammation in experimental heatstroke.
Authors: Chang CP, Huang WT, Cheng BC, Hsu CC, Lin MT
Neuropharmacology, 2007;52(3):1024-33.
Species: Mouse
Sample Type: Serum

Clostridium sordellii lethal toxin kills mice by inducing a major increase in lung vascular permeability.
Authors: Geny B, Khun H, Fitting C, Zarantonelli L, Mazuet C, Cayet N, Szatanik M, Prevost MC, Cavaillon JM, Huerre M, Popoff MR
Am. J. Pathol., 2007;170(3):1003-17.
Species: Mouse
Sample Type: Serum

Vaccinia virus infection attenuates innate immune responses and antigen presentation by epidermal dendritic cells.
Authors: Deng L, Dai P, Ding W, Granstein RD, Shuman S
J. Virol., 2006;80(20):9977-87.
Species: Mouse
Sample Type: Cell Culture Supernates

The urokinase plasminogen activator receptor is crucially involved in host defense during acute pyelonephritis.
Authors: Roelofs JJ, Rouschop KM, Teske GJ, Claessen N, Weening JJ, van der Poll T, Florquin S
Kidney Int., 2006;70(11):1942-7.
Species: Mouse
Sample Type: Tissue Homogenates

Bim deficiency leads to exacerbation and prolongation of joint inflammation in experimental arthritis.
Authors: Scatizzi JC, Bickel E, Hutcheson J, Haines GK, Perlman H
Arthritis Rheum., 2006;54(10):3182-93.
Species: Mouse
Sample Type: Tissue Homogenates

Protease-activated receptor-2 activation: a major role in the pathogenesis of Porphyromonas gingivalis infection.
Authors: Holzhausen M, Spolidorio LC, Ellen RP, Jobin MC, Steinhoff M, Andrade-Gordon P, Vergnolle N
Am. J. Pathol., 2006;168(4):1189-99.
Species: Mouse
Sample Type: subcutaneous chamber fluid

Tetrathiomolybdate is effective in a mouse model of arthritis.
Authors: McCubbin MD, Hou G, Abrams GD, Dick R, Brewer GJ
J. Rheumatol., 2006;33(12):2501-6.
Species: Mouse
Sample Type: Serum

Organ-specific role of MyD88 for gene regulation during polymicrobial peritonitis.
Authors: Weighardt H, Mages J, Jusek G, Kaiser-Moore S, Lang R, Holzmann B
Infect. Immun., 2006;74(6):3618-32.
Species: Mouse
Sample Type: Tissue Homogenates

Citrus polymethoxylated flavones improve lipid and glucose homeostasis and modulate adipocytokines in fructose-induced insulin resistant hamsters.
Authors: Li RW, Theriault AG, Au K, Douglas TD, Casaschi A, Kurowska EM, Mukherjee R
Life Sci., 2006;79(4):365-73.
Species: Mouse
Sample Type: Serum

CD27 contributes to the early systemic immune response to Mycobacterium tuberculosis infection but does not affect outcome.
Authors: Wieland CW, Kerver ME, Florquin S, Nolte MA, Borst J, van Lier R, van Oers MH, van der Poll T
Int. Immunol., 2006;18(11):1531-9.

Gender differences in murine airway responsiveness and lipopolysaccharide-induced inflammation.
Authors: Card JW, Carey MA, Bradbury JA, DeGraff LM, Morgan DL, Moorman MP, Flake GP, Zeldin DC
J. Immunol., 2006;177(1):621-30.
Species: Mouse
Sample Type: BALF

Absence of IL-1 receptor antagonist impaired wound healing along with aberrant NF-kappaB activation and a reciprocal suppression of TGF-beta signal pathway.
Authors: Ishida Y, Kondo T, Kimura A, Matsushima K, Mukaida N
J. Immunol., 2006;176(9):5598-606.
Species: Mouse
Sample Type: Tissue Homogenates

[D-Trp8]-gamma-melanocyte-stimulating hormone exhibits anti-inflammatory efficacy in mice bearing a nonfunctional MC1R (recessive yellow e/e mouse).
Authors: Getting SJ, Lam CW, Leoni G, Gavins FN, Grieco P, Perretti M
Mol. Pharmacol., 2006;70(6):1850-5.
Species: Mouse
Sample Type: Peritoneal Lavage

Allergic airway inflammation inhibits pulmonary antibacterial host defense.
Authors: Beisswenger C, Kandler K, Hess C, Garn H, Felgentreff K, Wegmann M, Renz H, Vogelmeier C, Bals R
J. Immunol., 2006;177(3):1833-7.
Species: Mouse
Sample Type: BALF

GM-CSF and the impaired pulmonary innate immune response following hyperoxic stress.
Authors: Baleeiro CE, Christensen PJ, Morris SB, Mendez MP, Wilcoxen SE, Paine R
Am. J. Physiol. Lung Cell Mol. Physiol., 2006;291(6):L1246-55.
Species: Mouse
Sample Type: Tissue Homogenates

Inhalation of ultrafine carbon particles triggers biphasic pro-inflammatory response in the mouse lung.
Authors: Andre E, Stoeger T, Takenaka S, Bahnweg M, Ritter B, Karg E, Lentner B, Reinhard C, Schulz H, Wjst M
Eur. Respir. J., 2006;28(2):275-85.
Species: Mouse
Sample Type: BALF

Endogenous interleukin-12 improves the early antimicrobial host response to murine Escherichia coli peritonitis.
Authors: Weijer S, Florquin S, van der Poll T
Shock, 2005;23(1):54-8.
Species: Mouse
Sample Type: Peritoneal Fluid

The class A macrophage scavenger receptor attenuates CXC chemokine production and the early infiltration of neutrophils in sterile peritonitis.
Authors: Cotena A, Platt N
J. Immunol., 2004;173(10):6427-32.
Species: Mouse
Sample Type: Cell Culture Supernates

Systemic up-regulation of sTNFR2 and IL-6 in Porphyromonas gingivalis pneumonia in mice.
Authors: Petelin M, Naruishi K, Shiomi N, Mineshiba J, Arai H, Nishimura F, Takashiba S, Murayama Y
Exp. Mol. Pathol., 2004;76(1):76-81.
Species: Mouse
Sample Type: Serum

Cytokine expression in experimental chronic otitis media with effusion in mice.
Authors: Maeda K, Hirano T, Ichimiya I, Kurono Y, Suzuki M, Mogi G
Laryngoscope, 2004;114(11):1967-72.
Species: Mouse
Sample Type: middle ear effusion

IL-1 receptor-associated kinase 1 mediates protection against Staphylococcus aureus infection.
Authors: Verdrengh M, Thomas JA, Hultgren OH
Microbes Infect., 2004;6(14):1268-72.
Species: Mouse
Sample Type: Serum

Increased interleukin-10 associated with low IL-6 concentration correlated with greater survival rates in mice infected by rabies virus vaccinated against it and immunomodulated with P. acnes.
Authors: Megid J, Kaneno R, Nozaki CN, Brito CJ, Almeida MF
Comp. Immunol. Microbiol. Infect. Dis., 2004;27(6):393-411.
Species: Mouse
Sample Type: Serum

Regulation of Pseudomonas aeruginosa corneal infection in IL-1 beta converting enzyme (ICE, caspase-1) deficient mice.
Authors: Thakur A, Barrett RP, McClellan S, Hazlett LD
Curr. Eye Res., 2004;29(4):225-33.
Species: Mouse
Sample Type: Tissue Homogenates

Suppression of graft coronary artery disease by a brief treatment with a selective epsilonPKC activator and a deltaPKC inhibitor in murine cardiac allografts.
Authors: Tanaka M, Terry RD, Mokhtari GK, Inagaki K, Koyanagi T, Kofidis T, Mochly-Rosen D, Robbins RC
Circulation, 2004;110(11):II194-9.
Species: Mouse
Sample Type: Tissue Homogenates

T cell-specific ablation of Fas leads to Fas ligand-mediated lymphocyte depletion and inflammatory pulmonary fibrosis.
Authors: Hao Z, Hampel B, Yagita H, Rajewsky K
J. Exp. Med., 2004;199(10):1355-65.
Species: Mouse
Sample Type: Serum

Responses of guinea pig pups during isolation in a novel environment may represent stress-induced sickness behaviors.
Authors: Hennessy MB, Deak T, Schiml-Webb PA, Wilson SE, Greenlee TM, McCall E
Physiol. Behav., 2004;81(1):5-13.
Species: Guinea Pig
Sample Type: Serum

Thrombomodulin mutant mice with a strongly reduced capacity to generate activated protein C have an unaltered pulmonary immune response to respiratory pathogens and lipopolysaccharide.
Authors: Rijneveld AW, Weijer S, Florquin S, Esmon CT, Meijers JC, Speelman P, Reitsma PH, ten Cate H, van der Poll T
Blood, 2003;103(5):1702-9.
Species: Mouse
Sample Type: BALF

Redundancy of a functional melanocortin 1 receptor in the anti-inflammatory actions of melanocortin peptides: studies in the recessive yellow (e/e) mouse suggest an important role for melanocortin 3 receptor.
Authors: Getting SJ, Christian HC, Lam CW, Gavins FN, Flower RJ, Schioth HB, Perretti M
J. Immunol., 2003;170(6):3323-30.
Species: Mouse
Sample Type: Peritoneal Fluid

IL-17, produced by lymphocytes and neutrophils, is necessary for lipopolysaccharide-induced airway neutrophilia: IL-15 as a possible trigger.
Authors: Ferretti S, Bonneau O, Dubois GR, Jones CE, Trifilieff A
J. Immunol., 2003;170(4):2106-12.
Species: Mouse
Sample Type: BALF

Interleukin-10 negatively regulates local cytokine and chemokine production but does not influence antibacterial host defense during murine pneumococcal meningitis.
Authors: Zwijnenburg PJ, van der Poll T, Florquin S, Roord JJ, van Furth AM
Infect. Immun., 2003;71(4):2276-9.
Species: Mouse
Sample Type: Tissue Homogenates

Caspase-1-deficient mice have delayed neutrophil apoptosis and a prolonged inflammatory response to lipopolysaccharide-induced acute lung injury.
Authors: Rowe SJ, Allen L, Ridger VC, Hellewell PG, Whyte MK
J. Immunol., 2002;169(11):6401-7.
Species: Mouse
Sample Type: BALF

The protein tyrosine kinase inhibitor AG126 prevents the massive microglial cytokine induction by pneumococcal cell walls.
Authors: Hanisch UK, Prinz M, Angstwurm K, Hausler KG, Kann O, Kettenmann H, Weber JR
Eur. J. Immunol., 2001;31(7):2104-15.
Species: Mouse
Sample Type: Cell Culture Supernates

Dendritic cells phagocytose and are activated by Treponema pallidum.
Authors: Bouis DA, Popova TG, Takashima A, Norgard MV
Infect. Immun., 2001;69(1):518-28.
Species: Mouse
Sample Type: Cell Culture Supernates

Amyloid beta and amylin fibrils induce increases in proinflammatory cytokine and chemokine production by THP-1 cells and murine microglia.
Authors: Yates SL, Burgess LH, Kocsis-Angle J, Antal JM, Dority MD, Embury PB, Piotrkowski AM, Brunden KR
J. Neurochem., 2000;74(3):1017-25.
Species: Mouse
Sample Type: Cell Culture Supernates

生物活性

< 0.5% cross-reactivity observed with available related molecules.< 50% cross-species reactivity observed with species tested.
背景

IL-1 beta (Interleukin-1 beta) is produced in response to inflammatory agents, infections, or microbial endotoxins. It plays a central role in immune and inflammatory responses, bone remodeling, fever, carbohydrate metabolism, and GH/IGF-I physiology. IL-1 beta dysregulation is implicated in many pathological conditions including sepsis, rheumatoid arthritis, inflammatory bowel disease, acute and chronic myelogenous leukemia, insulin-dependent diabetes mellitus, atherosclerosis, neuronal injury, and aging-related diseases. Intracellular cleavage of the IL-1 beta precursor by Caspase-1/ICE is a key step in the inflammatory response. IL-1 beta binds to IL-1 RI and IL-1 RII. The IL-1 receptor accessory protein (IL-1 RAcP) associates with IL-1 RI and is required for IL-1 RI signal transduction, and IL-1ra is a secreted molecule that functions as a competitive inhibitor of IL-1 bioactivity.

参考文献
  • Cancer Biomarkers
  • Chronic IL-1 beta-induced Neuroinflammation Is it Really that Bad?
  • Conventional/Classical Dendritic Cells
  • Cytokines and Receptors in Allergy and Asthma
  • Cytokines and Receptors in Angiogenesis
  • ICC / IHC Images: IL-1 beta/IL-1F2
  • IL-1 Family
  • Infectious Diseases
  • Inflammasomes: Intracellular Regulators of Pathogen
  • Inflammatory Mediators
  • Interactive Pathway: IL-1 Family Signaling Pathways
  • Isolation, Culture, and Identification of Natural Killer Cells
  • LTi Cells
  • Macrophage Activation Markers
  • Mini-review: Interleukin 1
  • Multiple Sclerosis and Myelin Related Molecules
  • Myeloid-derived Suppressor Cells (MDSC)
  • NCR-ILC3
  • Neuroinflammation
  • NOD-like Receptors and the Inflammasome
  • Platelets
  • Regulatory T Cells (Tregs)
  • T Cell Cytokine Signaling
  • Th17 Cells
  • Th9 Cells
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2)组化实验组织样本,需经过10%中性缓冲福尔马林固定24-72小时后,转移到75%酒精中送样,且保证样品管上标记清晰,不会被酒精渗漏模糊掉字迹。

3)组化实验蜡块和切片样本,常温运输,尽可能使用盒子装蜡块,避免互相之前摩擦影响样本;切片使用切片盒放置,避免玻片之间相关刮创。

4)您必须明确说明提供给乙方的实验材料的安全性,确保无致病性、无传染性,对人、动植物和环境友好安全,以保证实验技术人员的安全。

5)珍贵样本,请您只提供满足实验服务合同的所需量,剩余样本自己保存好以免造成样本的浪费,耽误您的实验进展。

6)甲方任何样本准备过程中的疑问,均可以咨询乙方。或者发邮件至labex@univ-bio.com,或者拨打4008-168-068转3。

2.为保证实验准确性,您需知悉以下内容:

1)非试剂盒验证样本,存在检出率低的风险,客户知晓并同意的情况下,Labex配合开展实验。

2)检出率是在MSD标准曲线范围内的数据,样本内因子含量超出标准品检测范围的情况下:若低于MSD标准曲线范围,则无法检出;若超过标准品检测上限,需实进一步稀释样本优化实验。MSD技术是目前市场上检测范围最宽(横跨4-5log)的多因子检测技术,但蛋白质组几万种蛋白浓度横跨10 log,不能一概而论。

3.实验服务过程中样本和试剂运输要求:

1)您可自行送样(方式包括快递以及亲送)到我们指定地点,但过程中要保证正确的运输条件,干冰货物或冰袋运输务必保证干冰充足和冰袋低温。并及时通知到我们,方便我们接收。

您还需要准备一份随样单(合同附件所示),标注您的姓名、合同号、样本信息、试剂信息,随快递一起寄送。

若由于您运输条件的原因,导致实验结果问题,相关责任由您承担。

实验室接收样本联系方式,提供寄送咨询: labex@univ-bio.com4008-168-0683

2)若您需要我们协助寄送样本时,我们会收取合理的寄送费用,以我们标准合同上所列收费为准。

4.实验服务合同结束后样本和试剂处置须知:

请您下单前确定实验服务合同结束后,样本处置情况。我们将严格按照合同约定执行。若您选择实验结束后样本,不保留,丢弃,我们会在实验结束后按国家标准自行处置掉相关实验材料。若您需要回寄相关样本,在您支付一定的运输费用后,我们将剩余样本在规定时间内返还给您。若您选择到付,需要保证您的样本是常温和蓝冰运输的,更高要求的运输条件不支持货到付款。若您不确定是否回寄,我们将保持您的样本1个月的时间,如超期,样本我们将自行处置,不在另行通知您。 如果您选择我们回寄样本给您,我们将快递信息邮件告知您,由您跟踪物流信息,并及时确认。如因您个人原因或者第三方物流原因造成的样本邮寄过程中的损耗,我们不承担任何责任。

5.实验服务种实验服务数据:

1) 我们承诺按照《实验样本信息及要求》中的实验方案进行实验并提供客观实验结果,但由于科研实验中存在诸多不确定因素以及未知难度和风险而导致结果的不确定性,不能保证所有的实验进度和实验结果完全达到甲方预期。在排除实验操作问题导致不良结果的前提下,您应尊重客观事实,承担实验结果与预期不一致的结果,包括实验结果是阴性的风险。因此在得不到预期结果的情况下,您仍应支付本次实验服务的全部已发生费用。

2) 实验服务是由专业技术达标的实验人员,遵循科学实验方法和标准操作流程,依照服务合同完成,优宁维保证将客观真实科学严谨的实验结果给到客户,但单次实验不足以阐明某些复杂的科学问题。

3) 您在收到实验数据后,5个工作日内(荧光相关实验3个工作日内)对实验数据质量提质疑,我们有义务解答。若是我们实验过程中的问题,我们承担全部责任;若是您验设计问题,您承担全部责任。我们承诺1个月的数据复核期,欢迎后续咨询。

6.客户知识产权保密协议:

1) 实验服务过程中产生的实验数据的知识产权归您所有,我们承诺不得以任何形式向除甲方以外的第三方提供该实验数据。对于相关的实验技术所有权归我们所有,您不得主张权利。

2) 我们双方共同致力于维护对方的商业机密和技术机密,包括本次合同所签订的文件,您都有义务进行保密。

7.服务承诺

如由于实验客观性需要重复实验、自然灾害、政府行为或其他乙方无法预见、无法避免和无法克服等不可抗力的客观原因造成合同无法按期履行的,我们将及时通知甲方,双方将视情况决定是否继续履行合同。如果由于客观原因造成某些实验项目不能执行的,合同结束时,退回相应款项。

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