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Human VEGF Quantikine ELISA Kit

(DVE00)



概述
货号 DVE00
描述

The Quantikine Human VEGF Immunoassay is a 4.5 hour solid phase ELISA designed to measure VEGF165 levels in cell culture supernates, serum, and plasma. It contains Sf 21-expressed recombinant human VEGF165 and antibodies raised against the recombinant protein. Results obtained for naturally occurring human VEGF and recombinant human VEGF121 showed linear curves that were parallel to the standard curves obtained using the Quantikine Human VEGF Immunoassay standards. These results indicate that this kit can be used to determine relative mass values for natural human VEGF.

别名 MVCD1; VAS; vascular endothelial growth factor A; Vascular permeability factor; Vasculotropin; VEGFA; VEGF-A; VEGFMGC70609; VPF; VPFvascular endothelial growth factor;
全称
Vascular Endothelial Growth Factor
反应种属 Human
形式 96-well strip plate
目标/特异性 Natural and recombinant human VEGF. This assay cross-reacts 67% with Canine VEGF and 82% with Feline VEGF.
性能
供应商 R&D Systems
检测类型 Solid Phase Sandwich ELISA
Entrez Gene IDs
7422 (Human); 22339 (Mouse); 83785 (Rat); 281572 (Bovine); 403802 (Canine); 493845 (Feline); 30682 (Zebrafish)
应用文献
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

FGFR-Dependent and -Independent Paracrine Signaling by Sunitinib-Resistant RCC
Mol Cell Biol, 2016;0(0):.
Species: Human
Sample Type: Cell Culture Supernates

Prognostic study for overall survival in patients with newly diagnosed POEMS syndrome
Authors: C Wang
Leukemia, 2016;0(0):.
Species: Human
Sample Type: Serum

Serum Interleukin-18, Fetuin-A, Soluble Intercellular Adhesion Molecule-1, and Endothelin-1 in Ankylosing Spondylitis, Psoriatic Arthritis, and SAPHO Syndrome
Int J Mol Sci, 2016;17(8):.
Species: Human
Sample Type: Serum

LXY6090 - a novel manassantin A derivative - limits breast cancer growth through hypoxia-inducible factor-1 inhibition
Onco Targets Ther, 2016;9(0):3829-40.
Species: Human
Sample Type: Whole Cells

Expression of Heat Shock Protein 27 in Melanoma Metastases Is Associated with Overall Response to Bevacizumab Monotherapy: Analyses of Predictive Markers in a Clinical Phase II Study
PLoS ONE, 2016;11(5):e0155242.
Species: Human
Sample Type: Plasma

Innovative Flow Cytometry Allows Accurate Identification of Rare Circulating Cells Involved in Endothelial Dysfunction
PLoS ONE, 2016;11(8):e0160153.
Species: Human
Sample Type: Plasma

Human neural stem cell-induced endothelial morphogenesis requires autocrine/paracrine and juxtacrine signaling
Sci Rep, 2016;6(0):29029.
Species: Human
Sample Type: Cell Culture Supernates

Activation of EGFR/p38/HIF-1? is pivotal for angiogenesis and tumorigenesis of malignantly transformed cells induced by hexavalent chromium
J Biol Chem, 2016;0(0):.
Species: Human
Sample Type: Cell Culture Supernates

Human lung fibroblasts may modulate dendritic cell phenotype and function: results from a pilot in vitro study
Authors: O Freynet, J Marchal-So, F Jean-Louis, A Mailleux, B Crestani, P Soler, L Michel
Respir Res, 2016;17(1):36.
Species: Human
Sample Type: Cell Culture Supernates

Association between Placental Lesions, Cytokines and Angiogenic Factors in Pregnant Women with Preeclampsia
Authors: Ingrid C Weel
PLoS ONE, 2016;11(6):e0157584.
Species: Human
Sample Type: Tissue Homogenates

A promising scaffold with excellent cytocompatibility and pro-angiogenesis action for dental tissue engineering: Strontium-doped calcium polyphosphate
Authors: H Qin, Z Yang, L Li, X Yang, J Liu, X Chen, X Yu
Dent Mater J, 2016;35(2):241-9.
Species: Human
Sample Type: Cell Culture Supernates

Lysyl Oxidase (LOX) transcriptionally regulates SNAI2 expression and TIMP4 secretion in human cancers
Authors: M Boufraqech, L Zhang, N Nilubol, SM Sadowski, S Kotian, MM Quezado, E Kebebew
Clin Cancer Res, 2016;0(0):.
Species: Human
Sample Type: Cell Culture Supernates

VEGF potentiates GD3-mediated immune suppression by human ovarian cancer cells
Authors: IV Tiper, SM Temkin, S Spiegel, SE Goldblum, RL Giuntoli, M Oelke, JP Schneck, TJ Webb
Clin Cancer Res, 2016;0(0):.
Species: Human
Sample Type: Cell Culture Supernates

The anti-angiogenic and cytotoxic effects of the boswellic acid analog BA145 are potentiated by autophagy inhibitors.
Authors: Pathania A, Wani Z, Guru S, Kumar S, Bhushan S, Korkaya H, Seals D, Kumar A, Mondhe D, Ahmed Z, Chandan B, Malik F
Mol Cancer, 2015;14(1):6.
Species: Human
Sample Type: Cell Culture Supernates

STAT3 Protein Regulates Vascular Smooth Muscle Cell Phenotypic Switch by Interaction with Myocardin.
Authors: Liao X, Wang N, Zhao D, Zheng D, Zheng L, Xing W, Ma W, Bao L, Dong J, Zhang T
J Biol Chem, 2015;290(32):19641-52.
Species: Human
Sample Type: Cell Culture Supernates

Intertumor heterogeneity in vascularity and invasiveness of artificial melanoma brain metastases.
Authors: Simonsen T, Gaustad J, Rofstad E
J Exp Clin Cancer Res, 2015;34(0):150.
Species: Human
Sample Type: Cell Culture Supernates

miR-126-3p Inhibits Thyroid Cancer Cell Growth and Metastasis, and Is Associated with Aggressive Thyroid Cancer.
Authors: Xiong Y, Kotian S, Zeiger M, Zhang L, Kebebew E
PLoS ONE, 2015;10(8):e0130496.
Species: Human
Sample Type: Cell Culture Supernates

Selecting bioactive phenolic compounds as potential agents to inhibit proliferation and VEGF expression in human ovarian cancer cells.
Authors: He Z, Li B, Rankin G, Rojanasakul Y, Chen Y
Oncol Lett, 2015;9(3):1444-1450.

Selective Interference Targeting of Lnk in Umbilical Cord-Derived Late Endothelial Progenitor Cells Improves Vascular Repair, Following Hind Limb Ischemic Injury, via Regulation of JAK2/STAT3 Signaling.
Authors: Lee, Sang Hun, Lee, Kyeung B, Lee, Jun Hee, Kang, Songhwa, Kim, Hwi Gon, Asahara, Takayuki, Kwon, Sang Mo
Stem Cells, 2015;33(5):1490-500.
Species: Human
Sample Type: Cell Culture Supernates

Gain of HIF-1alpha under normoxia in cancer mediates immune adaptation through the AKT/ERK and VEGFA axes.
Authors: Lee Y, Bae H, Noh K, Song K, Ye S, Mao C, Lee K, Wu T, Kim T
Clin Cancer Res, 2015;21(6):1438-46.

Rac1 Regulates Endometrial Secretory Function to Control Placental Development.
Authors: Davila J, Laws M, Kannan A, Li Q, Taylor R, Bagchi M, Bagchi I
PLoS Genet, 2015;11(8):e1005458.
Species: Human
Sample Type: Cell Culture Supernates

Deleted in malignant brain tumors 1 (DMBT1) elicits increased VEGF and decreased IL-6 production in type II lung epithelial cells.
Authors: Muller H, Nagel C, Weiss C, Mollenhauer J, Poeschl J
BMC Pulm Med, 2015;15(0):32.
Species: Human
Sample Type: Tracheal Aspirates

The tyrosine phosphatase SHP-1 regulates hypoxia inducible factor-1alpha (HIF-1alpha) protein levels in endothelial cells under hypoxia.
Authors: Alig S, Stampnik Y, Pircher J, Rotter R, Gaitzsch E, Ribeiro A, Wornle M, Krotz F, Mannell H
PLoS ONE, 2015;10(3):e0121113.
Species: Human
Sample Type: Cell Culture Supernates

Identification of tumour-reactive lymphatic endothelial cells capable of inducing progression of gastric cancer.
Authors: Tokumoto M, Tanaka H, Tauchi Y, Kasashima H, Kurata K, Yashiro M, Sakurai K, Toyokawa T, Kubo N, Amano R, Kimura K, Muguruma K, Maeda K, Ohira M, Hirakawa K
Br J Cancer, 2015;113(7):1046-54.
Species: Human
Sample Type: Cell Culture Supernates

Inhibition of placental growth factor in renal cell carcinoma.
Authors: Bessho H, Wong B, Huang D, Siew E, Huang D, Tan J, Ong C, Tan S, Matsumoto K, Iwamura M, Teh B
Anticancer Res, 2015;35(1):531-41.
Species: Human
Sample Type: Cell Culture Supernates

Obstructive sleep apnoea syndrome, endothelial function and markers of endothelialization. Changes after CPAP.
Authors: Munoz-Hernandez R, Vallejo-Vaz A, Sanchez Armengol A, Moreno-Luna R, Caballero-Eraso C, Macher H, Villar J, Merino A, Castell J, Capote F, Stiefel P
PLoS ONE, 2015;10(3):e0122091.
Species: Human
Sample Type: Serum

Significant Correlation between Retinal Venous Tortuosity and Aqueous Vascular Endothelial Growth Factor Concentration in Eyes with Central Retinal Vein Occlusion.
Authors: Yasuda S, Kachi S, Kondo M, Ueno S, Kaneko H, Terasaki H
PLoS ONE, 2015;10(7):e0134267.
Species: Human
Sample Type: Aqueous humor

VEGF in patients with advanced hepatocellular carcinoma receiving intra-arterial chemotherapy.
Authors: Matsui D, Nagai H, Mukozu T, Ogino Y, Sumino Y
Anticancer Res, 2015;35(4):2205-10.
Species: Human
Sample Type: Serum

MEK Inhibitor PD-0325901 Overcomes Resistance to PI3K/mTOR Inhibitor PF-5212384 and Potentiates Antitumor Effects in Human Head and Neck Squamous Cell Carcinoma.
Authors: Mohan S, Vander Broek R, Shah S, Eytan D, Pierce M, Carlson S, Coupar J, Zhang J, Cheng H, Chen Z, Van Waes C
Clin Cancer Res, 2015;21(17):3946-56.
Species: Human
Sample Type: Cell Culture Supernates

Tanshinone IIA inhibits HIF-1alpha and VEGF expression in breast cancer cells via mTOR/p70S6K/RPS6/4E-BP1 signaling pathway.
Authors: Li G, Shan C, Liu L, Zhou T, Zhou J, Hu X, Chen Y, Cui H, Gao N
PLoS ONE, 2015;10(2):e0117440.
Species: Human
Sample Type: Cell Culture Supernates

Prognostic significance of pretreatment VEGF, survivin, and Smac/DIABLO serum levels in patients with serous ovarian carcinoma.
Authors: Dobrzycka B, Mackowiak-Matejczyk B, Terlikowska K, Kulesza-Bronczyk B, Kinalski M, Terlikowski S
Tumour Biol, 2015;0(0):4157.
Species: Human
Sample Type: Serum

In situ normoxia enhances survival and proliferation rate of human adipose tissue-derived stromal cells without increasing the risk of tumourigenesis.
Authors: Choi, Jane Ru, Pingguan-Murphy, Belinda, Wan Abas, Wan Abu, Yong, Kar Wey, Poon, Chi Tat, Noor Azmi, Mat Aden, Omar, Siti Zaw, Chua, Kien Hui, Xu, Feng, Wan Safwani, Wan Kama
PLoS ONE, 2015;10(1):e0115034.
Species: Human
Sample Type: Cell Culture Supernates

Survivin expression promotes VEGF-induced tumor angiogenesis via PI3K/Akt enhanced beta-catenin/Tcf-Lef dependent transcription.
Authors: Fernandez J, Rodriguez D, Valenzuela M, Calderon C, Urzua U, Munroe D, Rosas C, Lemus D, Diaz N, Wright M, Leyton L, Tapia J, Quest A
Mol Cancer, 2014;13(0):209.
Species: Human
Sample Type: Cell Culture Supernates

Epidithiodiketopiperazines (ETPs) exhibit in vitro antiangiogenic and in vivo antitumor activity by disrupting the HIF-1alpha/p300 complex in a preclinical model of prostate cancer.
Authors: Reece K, Richardson E, Cook K, Campbell T, Pisle S, Holly A, Venzon D, Liewehr D, Chau C, Price D, Figg W
Mol Cancer, 2014;13(0):91.
Species: Human
Sample Type: Cell Culture Supernates

Evaluation of a new recombinant oncolytic vaccinia virus strain GLV-5b451 for feline mammary carcinoma therapy.
Authors: Adelfinger M, Gentschev I, Grimm de Guibert J, Weibel S, Langbein-Laugwitz J, Hartl B, Murua Escobar H, Nolte I, Chen N, Aguilar R, Yu Y, Zhang Q, Frentzen A, Szalay A
PLoS ONE, 2014;9(8):e104337.
Species: Feline
Sample Type: Cell Culture Supernates

Sunitinib suppress neuroblastoma growth through degradation of MYCN and inhibition of angiogenesis.
Authors: Calero R, Morchon E, Johnsen J, Serrano R
PLoS ONE, 2014;9(4):e95628.
Species: Human
Sample Type: Cell Culture Supernates

Effects of a single intravitreal injection of aflibercept and ranibizumab on glomeruli of monkeys.
Authors: Tschulakow A, Christner S, Julien S, Ludinsky M, van der Giet M, Schraermeyer U
PLoS ONE, 2014;9(11):e113701.
Species: Primate - macaca fascicularis
Sample Type: Plasma

Cbx4 governs HIF-1alpha to potentiate angiogenesis of hepatocellular carcinoma by its SUMO E3 ligase activity.
Authors: Li J, Xu Y, Long X, Wang W, Jiao H, Mei Z, Yin Q, Ma L, Zhou A, Wang L, Yao M, Xia Q, Chen G
Cancer Cell, 2014;25(1):118-31.
Species: Human
Sample Type: Cell Culture Supernates

RUNX3 inhibits hypoxia-inducible factor-1alpha protein stability by interacting with prolyl hydroxylases in gastric cancer cells.
Authors: Lee S, Bae S, Kim K, Lee Y
Oncogene, 2014;33(11):1458-67.
Species: Human
Sample Type: Whole Cells

Autophagy facilitates TLR4- and TLR3-triggered migration and invasion of lung cancer cells through the promotion of TRAF6 ubiquitination.
Authors: Zhan Z, Xie X, Cao H, Zhou X, Zhang X, Fan H, Liu Z
Autophagy, 2014;10(2):257-68.
Species: Human
Sample Type: Cell Culture Supernates

WNT5A induces release of exosomes containing pro-angiogenic and immunosuppressive factors from malignant melanoma cells.
Authors: Ekstrom E, Bergenfelz C, von Bulow V, Serifler F, Carlemalm E, Jonsson G, Andersson T, Leandersson K
Mol Cancer, 2014;13(0):88.
Species: Human
Sample Type: cell culture supernate

Metabolic impact of anti-angiogenic agents on U87 glioma cells.
Authors: Mesti T, Savarin P, Triba M, Le Moyec L, Ocvirk J, Banissi C, Carpentier A
PLoS ONE, 2014;9(6):e99198.
Species: Human
Sample Type: cell culture supernate

Temsirolimus inhibits proliferation and migration in retinal pigment epithelial and endothelial cells via mTOR inhibition and decreases VEGF and PDGF expression.
Authors: Liegl, Raffael, Koenig, Susanna, Siedlecki, Jakob, Haritoglou, Christos, Kampik, Anselm, Kernt, Marcus
PLoS ONE, 2014;9(2):e88203.
Species: Human
Sample Type: Cell Culture Supernates

Mobilization of circulating endothelial progenitor cells correlates with the clinical course of hantavirus disease.
Authors: Krautkramer E, Grouls S, Hettwer D, Rafat N, Tonshoff B, Zeier M
J Virol, 2014;88(1):483-9.
Species: Human
Sample Type: Plasma

Heat shock protein 27 attenuates neointima formation and accelerates reendothelialization after arterial injury and stent implantation: importance of vascular endothelial growth factor up-regulation.
Authors: Ma X, Hibbert B, McNulty M, Hu T, Zhao X, Ramirez F, Simard T, de Belleroche J, O'Brien E
FASEB J, 2014;28(2):594-602.
Species: Human
Sample Type: Cell Culture Supernates

DeltaNp63 promotes pediatric neuroblastoma and osteosarcoma by regulating tumor angiogenesis.
Authors: Bid, Hemant K, Roberts, Ryan D, Cam, Maren, Cam M, Audino A, Audino, Anthony, Kurmasheva, Raushan, Lin, Jiayuh, Houghton, Peter J, Cam, Hakan, Cam H
Cancer Res, 2014;74(1):320-9.
Species: Human
Sample Type: Cell Culture Supernates

Gene electro transfer of plasmid encoding vascular endothelial growth factor for enhanced expression and perfusion in the ischemic swine heart.
Authors: Hargrave, Barbara, Strange, Robert J, Navare, Sagar, Stratton, Michael, Burcus, Nina, Murray, Len, Lundberg, Cathryn, Bulysheva, Anna, Li, Fanying, Heller, Richard
PLoS ONE, 2014;9(12):e115235.
Species: Human
Sample Type: Tissue Homogenates

Analysis of plasma cytokines and angiogenic factors in patients with pretreated urothelial cancer receiving Pazopanib: the role of circulating interleukin-8 to enhance the prognostic accuracy.
Authors: Necchi A, Pennati M, Zaffaroni N, Landoni E, Giannatempo P, Raggi D, Schwartz L, Morosi C, Crippa F, Fare E, Nicolai N, Lanocita R, Sava T, Sacco C, Messina C, Ortega C, De Braud F, Salvioni R, Daidone M, Gianni A, Mariani L
Br J Cancer, 2014;110(1):26-33.
Species: Human
Sample Type: Plasma

A novel splice variant of calcium and integrin-binding protein 1 mediates protein kinase D2-stimulated tumour growth by regulating angiogenesis.
Authors: Armacki, M, Joodi, G, Nimmagadda, S C, de Kimpe, L, Pusapati, G V, Vandoninck, S, Van Lint, J, Illing, A, Seufferlein, T
Oncogene, 2014;33(9):1167-80.
Species: Human
Sample Type: Cell Culture Supernates

COX-2 silencing enhances tamoxifen antitumor activity in breast cancer in vivo and in vitro.
Authors: Du Y, Shi A, Han B, Li S, Wu D, Jia H, Zheng C, Ren L, Fan Z
Int J Oncol, 2014;44(4):1385-93.
Species: Human
Sample Type: Cell Culture Supernates

Effects of sFlt-1 and alpha 2-macroglobulin on vascular endothelial growth factor-induced endothelin-1 upregulation in human microvascular endothelial cells.
Authors: Yi K, Jung S, Cho G, Seol H, Hong S, Oh M, Kim H
Placenta, 2014;35(1):64-9.
Species: Human
Sample Type: Cell Culture Supernates

Role of serum VEGFA, TIMP2, MMP2 and MMP9 in monitoring response to adjuvant radiochemotherapy in patients with primary cervical cancer--results of a companion protocol of the randomized NOGGO-AGO phase III clinical trial.
Authors: Braicu E, Gasimli K, Richter R, Nassir M, Kummel S, Blohmer J, Yalcinkaya I, Chekerov R, Ignat I, Ionescu A, Mentze M, Fotopoulou C, Pop C, Lichtenegger W, Sehouli J
Anticancer Res, 2014;34(1):385-91.
Species: Human
Sample Type: Serum

Peroxisome proliferator-activated receptor gamma ligands inhibit VEGF-mediated vasculogenic mimicry of prostate cancer through the AKT signaling pathway.
Authors: Qin L, Ren Y, Chen A, Guo F, Xu F, Gong C, Cheng P, Du Y, Liao H
Mol Med Rep, 2014;10(1):276-82.
Species: Human
Sample Type: Cell Culture Supernates

Osteosarcoma cells promote the production of pro-tumor cytokines in mesenchymal stem cells by inhibiting their osteogenic differentiation through the TGF-beta/Smad2/3 pathway.
Authors: Tu B, Peng Z, Fan Q, DU L, Yan W, Tang T
Exp Cell Res, 2014;320(1):164-73.
Species: Human
Sample Type: cell culture supernate

Systemic upregulation of PDGF-B in patients with neovascular AMD.
Authors: Zehetner C, Kirchmair R, Neururer S, Kralinger M, Bechrakis N, Kieselbach G
Invest Ophthalmol Vis Sci, 2014;55(1):337-44.
Species: Human
Sample Type: Plasma

Interferon-beta inhibits glioma angiogenesis through downregulation of vascular endothelial growth factor and upregulation of interferon inducible protein 10.
Authors: Takano S, Ishikawa E, Matsuda M, Yamamoto T, Matsumura A
Int J Oncol, 2014;45(5):1837-46.
Species: Human
Sample Type: cell supernates

O-GlcNAc modification of transcription factor Sp1 mediates hyperglycemia-induced VEGF-A upregulation in retinal cells.
Authors: Donovan K, Alekseev O, Qi X, Cho W, Azizkhan-Clifford J
Invest Ophthalmol Vis Sci, 2014;55(12):7862-73.
Species: Human
Sample Type: Cell Culture Supernates

alpha6-Integrin is required for the adhesion and vasculogenic potential of hemangioma stem cells.
Authors: Smadja D, Guerin C, Boscolo E, Bieche I, Mulliken J, Bischoff J
Stem Cells, 2014;32(3):684-93.
Species: Human
Sample Type: Cell Culture Supernates

Prognostic and predictive value of VEGF, sVEGFR-2 and CEA in mCRC studies comparing cediranib, bevacizumab and chemotherapy.
Authors: Jurgensmeier J, Schmoll H, Robertson J, Brooks L, Taboada M, Morgan S, Wilson D, Hoff P
Br J Cancer, 2013;108(6):1316-23.
Species: Human
Sample Type: Plasma

The mechanism through which octreotide inhibits hepatic stellate cell activity.
Authors: Wang J, Wang L, Song G, Han B
Mol Med Rep, 2013;7(5):1559-64.
Species: Human
Sample Type: Cell Culture Supernates

Long-term survival and biomarker correlates of tasquinimod efficacy in a multicenter randomized study of men with minimally symptomatic metastatic castration-resistant prostate cancer.
Authors: Armstrong A, Haggman M, Stadler W, Gingrich J, Assikis V, Polikoff J, Damber J, Belkoff L, Nordle O, Forsberg G, Carducci M, Pili R
Clin Cancer Res, 2013;19(24):6891-901.
Species: Human
Sample Type: Plasma

Caspase 3 involves in neuroplasticity, microglial activation and neurogenesis in the mice hippocampus after intracerebral injection of kainic acid.
Authors: Tzeng, Tsai-Ten, Tsay, Huey-Jen, Chang, Luping, Hsu, Chia-Lin, Lai, Tzu-Hsua, Huang, Fong-Lee, Shiao, Young-Ji
J Biomed Sci, 2013;20(0):90.
Species: Human
Sample Type: Cell Culture Supernates

Inhibition of STAT3 reduces astrocytoma cell invasion and constitutive activation of STAT3 predicts poor prognosis in human astrocytoma.
Authors: Liang, Qinchuan, Ma, Chenkai, Zhao, Yang, Gao, Guodong, Ma, Jie
PLoS ONE, 2013;8(12):e84723.
Species: Human
Sample Type: Cell Culture Supernates

The contributions of HIF-target genes to tumor growth in RCC.
Authors: Zhang, Ting, Niu, Xiaohua, Liao, Lili, Cho, Eun-Ah, Yang, Haifeng
PLoS ONE, 2013;8(11):e80544.
Species: Human
Sample Type: Cell Lysate

The role of SDF-1-CXCR4/CXCR7 axis in biological behaviors of adipose tissue-derived mesenchymal stem cells in vitro.
Authors: Li Q, Zhang A, Tao C, Li X, Jin P
Biochem Biophys Res Commun, 2013;441(3):675-80.
Species: Human
Sample Type: Cell Culture Supernates

Effect of platelet lysate on human cells involved in different phases of wound healing.
Authors: Barsotti M, Losi P, Briganti E, Sanguinetti E, Magera A, Al Kayal T, Feriani R, Di Stefano R, Soldani G
PLoS ONE, 2013;8(12):e84753.
Species: Human
Sample Type: Cell Lysate

Designing nanotopographical density of extracellular matrix for controlled morphology and function of human mesenchymal stem cells.
Authors: Kim J, Kim H, Lim K, Kim Y, Seonwoo H, Park S, Lim H, Kim D, Suh K, Choung P, Choung Y, Chung J
Sci Rep, 2013;3(0):3552.
Species: Human
Sample Type: Cell Culture Supernates

Transcriptional repression of VEGF by ZNF24: mechanistic studies and vascular consequences in vivo.
Authors: Jia, Di, Hasso, Sean M, Chan, Joanne, Filingeri, Domenic, D'Amore, Patricia, Rice, Lori, Pampo, Christin, Siemann, Dietmar, Zurakowski, David, Rodig, Scott J, Moses, Marsha A
Blood, 2013;121(4):707-15.
Species: Human
Sample Type: Cell Culture Supernates

A metabolic shift favoring sphingosine 1-phosphate at the expense of ceramide controls glioblastoma angiogenesis.
Authors: Abuhusain, Hazem J, Matin, Azadeh, Qiao, Qiao, Shen, Han, Kain, Nupur, Day, Bryan W, Stringer, Brett W, Daniels, Benjamin, Laaksonen, Maarit A, Teo, Charlie, McDonald, Kerrie L, Don, Anthony
J Biol Chem, 2013;288(52):37355-64.
Species: Human
Sample Type: Cell Culture Supernates

Dose selection trial of metronomic oral vinorelbine monotherapy in patients with metastatic cancer: a hellenic cooperative oncology group clinical translational study.
Authors: Briasoulis, Evangelo, Aravantinos, Gerasimo, Kouvatseas, George, Pappas, Periklis, Biziota, Eirini, Sainis, Ioannis, Makatsoris, Thomas, Varthalitis, Ioannis, Xanthakis, Ioannis, Vassias, Antonios, Klouvas, George, Boukovinas, Ioannis, Fountzilas, George, Syrigos, Kostanti, Kalofonos, Haralamb, Samantas, Epaminon
BMC Cancer, 2013;13(1):263.
Species: Human
Sample Type: Plasma

Clinical outcome, proteome kinetics and angiogenic factors in serum after thermoablation of colorectal liver metastases.
Authors: Wertenbroek, Marieke, Schepers, Marianne, Kamminga-Rasker, Hannetta, Bottema, Jan T, Muller Kobold, Anneke C, Roelofsen, Han, de Jong, Koert P
BMC Cancer, 2013;13(1):266.
Species: Human
Sample Type: Serum

Apricoxib, a novel inhibitor of COX-2, markedly improves standard therapy response in molecularly defined models of pancreatic cancer.
Clin. Cancer Res., 2012;18(18):5031-42.
Species: Human
Sample Type: Plasma

Semaphorin 4A exerts a proangiogenic effect by enhancing vascular endothelial growth factor-A expression in macrophages.
Authors: Meda C, Molla F, De Pizzol M
J. Immunol., 2012;188(8):4081-92.
Species: Human
Sample Type: Cell Culture Supernates

Biomarkers for antitumor activity of bevacizumab in gastric cancer models.
Authors: Yamashita-Kashima Y, Fujimoto-Ouchi K, Yorozu K, Kurasawa M, Yanagisawa M, Yasuno H, Mori K
BMC Cancer, 2012;12(0):37.
Species: Human
Sample Type: Tissue Homogenates

Cardiac angiogenic imbalance leads to peripartum cardiomyopathy.
Authors: Patten IS, Rana S, Shahul S, Rowe GC, Jang C, Liu L, Hacker MR, Rhee JS, Mitchell J, Mahmood F, Hess P, Farrell C, Koulisis N, Khankin EV, Burke SD, Tudorache I, Bauersachs J, del Monte F, Hilfiker-Kleiner D, Karumanchi SA, Arany Z
Nature, 2012;485(7398):333-8.
Species: Human
Sample Type: Plasma

Serum neurotensin (NT) is increased in psoriasis and NT induces vascular endothelial growth factor release from human mast cells.
Authors: Vasiadi M, Therianou A, Alysandratos KD, Katsarou-Katsari A, Petrakopoulou T, Theoharides A, Papadavid E, Stavrianeas N, Antoniou C, Kalogeromitros D, Theoharides TC
Br. J. Dermatol., 2012;166(6):1349-52.
Species: Human
Sample Type: Cell Culture Supernates

Plasma biomarkers as predictors of outcome in patients with advanced hepatocellular carcinoma.
Authors: Llovet JM, Pena CE, Lathia CD, Shan M, Meinhardt G, Bruix J, Pallota MG, Zarba JJ, Boyer M, Riordan S, Strickland A, Tebbutt N, Thomson B, Borbath I, De Greve J, Van Laethem J-, Van Steenbergen W, Van Vlierberghe H, Barrios C, Cosme de Oliveira A, Kotzev I, Takov D, Tchernev K, Burak K, Ma M, Metrakos P, Olweny C, Sherman M, Gamargo Garate C, Martinez-Castillo J, Beaugrand M, Bennouna J, Blanc J-, Bronowicki J-, Degos F, Dominguez S, Grange J-, Hillon P, Raoul J-, Seitz J-, Blum H, Buggisch P, Caspary W, Dollinger M, Gerken G, Goke B, Gregor M, Greten T, Haussinger D, Hilgard P, Scherübl J, Scheulen M, Schmid R, Spengler U, Wiest R, Zeuzem S, Arvanitakis C, Germanidis G, Katsos I, Figer A, Stemmer S, Amadori D, Bolondi L, Cognetti F, Craxi A, Farinati F, Gridelli C, Martoni A, Mazzaferro V, Porta C, Ricci S, Sangiovanni A, Santoro A, Trevisani F, Cisnero Garza LE, Gane E, O'Donnell A, Leon J, Lozano A, Jassem J, Rydzewska G, Szawlowski A, Tomczak P, Badulescu F, Miron L, Kubyshkin V, Bruix J, Forner A, Bustamante Schneider J, Diago M, Montero Alvarez JL, Pascual S, Ruíz del Arbol L, Sangro B, Solá R, Tabernero J, Muellhaupt B, Roth A, Jeffry Evans TR, Falk S, Meyer T, Reeves H, Ross P, Befeler A, Boyer T, Britten C, Byrne T, Garcia-Tsao G, Gold P, Goldenberg A, Heuman D, Kennedy P, Koch A, Llovet JM, Marrero J, Schilsky M, Schwartz J, Schwartz M
Clin. Cancer Res., 2012;18(8):2290-300.
Species: Human
Sample Type: Plasma

Late SV40 factor (LSF) enhances angiogenesis by transcriptionally up-regulating matrix metalloproteinase-9 (MMP-9).
Authors: Santhekadur PK, Gredler R, Chen D
J. Biol. Chem., 2012;287(5):3425-32.
Species: Human
Sample Type: Cell Culture Supernates

Human Herpesvirus 8 (HHV8) sequentially shapes the NK cell repertoire during the course of asymptomatic infection and Kaposi sarcoma.
Authors: Dupuy S, Lambert M, Zucman D, Choukem SP, Tognarelli S, Pages C, Lebbe C, Caillat-Zucman S
PLoS Pathog., 2012;8(1):e1002486.
Species: Human
Sample Type: Cell Culture Supernates

XELIRI-bevacizumab versus FOLFIRI-bevacizumab as first-line treatment in patients with metastatic colorectal cancer: a Hellenic Cooperative Oncology Group phase III trial with collateral biomarker analysis.
BMC Cancer, 2012;12(0):271.
Species: Human
Sample Type: Plasma

Phase I trial of combretastatin A4 phosphate (CA4P) in combination with bevacizumab in patients with advanced cancer.
Clin. Cancer Res., 2012;18(12):3428-39.
Species: Human
Sample Type: Plasma

Bevacizumab attenuates major signaling cascades and eIF4E translation initiation factor in multiple myeloma cells.
Authors: Attar-Schneider O, Drucker L, Zismanov V
Lab. Invest., 2012;92(2):178-90.
Species: Human
Sample Type: Cell Culture Supernates

Neurotensin and CRH interactions augment human mast cell activation.
Authors: Alysandratos K, Asadi S, Angelidou A, Zhang B, Sismanopoulos N, Yang H, Critchfield A, Theoharides T
PLoS ONE, 2012;7(11):e48934.
Species: Human
Sample Type: Cell Culture Supernates

A phase I trial and pharmacokinetic study of sorafenib in children with refractory solid tumors or leukemias: a Children's Oncology Group Phase I Consortium report.
Authors: Widemann B, Kim A, Fox E, Baruchel S, Adamson P, Ingle A, Glade Bender J, Burke M, Weigel B, Stempak D, Balis F, Blaney S
Clin Cancer Res, 2012;18(21):6011-22.
Species: Human
Sample Type: Plasma

Hypoxia potentiates glioma-mediated immunosuppression.
Authors: Wei J, Wu A, Kong LY, Wang Y, Fuller G, Fokt I, Melillo G, Priebe W, Heimberger AB
PLoS ONE, 2012;6(1):e16195.
Species: Human
Sample Type: Cell Culture Supernates

Met Receptor Tyrosine Kinase Signaling Induces Secretion of the Angiogenic Chemokine Interleukin-8/CXCL8 in Pancreatic Cancer.
Authors: Hill KS, Gaziova I, Harrigal L
PLoS ONE, 2012;7(7):e40420.
Species: Human
Sample Type: Cell Culture Supernates

Comparison of the levels of the growth factors in umbilical cord serum and human milk and its clinical significance.
Authors: Patki S, Patki U, Patil R, Indumathi S, Kaingade P, Bulbule A, Nikam A, Pishte A
Cytokine, 2012;59(2):305-8.
Species: Human
Sample Type: umbilical cord serum

CD34+ progenitor cells likely are involved in the good functional recovery after intracerebral hemorrhage in humans.
Authors: Sobrino T, Arias S, Perez-Mato M, Agulla J, Brea D, Rodriguez-Yanez M, Castillo J
J. Neurosci. Res., 2011;89(7):979-85.
Species: Human
Sample Type: Serum

Synergistic effects of imatinib and carboplatin on VEGF, PDGF and PDGF-Ralpha/beta expression in squamous cell carcinoma of the head and neck in vitro.
Authors: Schultz JD, Rotunno S, Riedel F, Anders C, Erben P, Hofheinz RD, Faber A, Thorn C, Sommer JU, Hormann K, Sauter A
Int. J. Oncol., 2011;38(4):1001-12.
Species: Human
Sample Type: Cell Lysates

Pharmacodynamic and pharmacogenetic angiogenesis-related markers of first-line FOLFOXIRI plus bevacizumab schedule in metastatic colorectal cancer.
Authors: Loupakis F, Cremolini C, Fioravanti A
Br. J. Cancer, 2011;104(8):1262-9.
Species: Human
Sample Type: Plasma

Expansion of human cardiac stem cells in physiological oxygen improves cell production efficiency and potency for myocardial repair.
Authors: Li TS, Cheng K, Malliaras K, Matsushita N, Sun B, Marban L, Zhang Y, Marban E
Cardiovasc. Res., 2011;89(1):157-65.
Species: Human
Sample Type: Cell Culture Supernates

Levels of circulating CD45(dim)CD34(+)VEGFR2(+) progenitor cells correlate with outcome in metastatic renal cell carcinoma patients treated with tyrosine kinase inhibitors.
Authors: Farace F, Gross-Goupil M, Tournay E, Taylor M, Vimond N, Jacques N, Billiot F, Mauguen A, Hill C, Escudier B
Br. J. Cancer, 2011;104(7):1144-50.
Species: Human
Sample Type: Plasma

Hypoxia-inducible factors in human pulmonary arterial hypertension: a link to the intrinsic myeloid abnormalities.
Authors: Farha S, Asosingh K, Xu W, Sharp J, George D, Comhair S, Park M, Tang WH, Loyd JE, Theil K, Tubbs R, Hsi E, Lichtin A, Erzurum SC
Blood, 2011;117(13):3485-93.
Species: Human
Sample Type: Plasma

Mechanism-related circulating proteins as biomarkers for clinical outcome in patients with unresectable hepatocellular carcinoma receiving sunitinib.
Authors: Harmon CS, DePrimo SE, Raymond E, Cheng AL, Boucher E, Douillard JY, Lim HY, Kim JS, Lechuga MJ, Lanzalone S, Lin X, Faivre S
J Transl Med, 2011;9(0):120.
Species: Human
Sample Type: Plasma

Inflammation associated with obesity: relationship with blood and bone marrow endothelial cells.
Authors: McGuire TR, Brusnahan SK, Bilek LD, Jackson JD, Kessinger MA, Berger AM, Garvin KL, O'Kane BJ, Tuljapurkar SR, Sharp JG
Obesity (Silver Spring), 2011;19(11):2130-6.
Species: Human
Sample Type: Plasma

Stromal interaction essential for vascular endothelial growth factor A-induced tumour growth via transforming growth factor-beta signalling.
Authors: Weidenaar AC, Ter Elst A, Kampen KR, Meeuwsen-de Boer TG, de Jonge HJ, Scherpen FJ, den Dunnen WF, Kamps WA, de Bont ES
Br. J. Cancer, 2011;105(12):1856-63.
Species: Human
Sample Type: Cell Culture Supernates

Vascular endothelial growth factor-A (VEGF-A) and chemokine ligand-2 (CCL2) in Amyotrophic Lateral Sclerosis (ALS) patients.
Authors: Gupta PK, Prabhakar S
J Neuroinflammation, 2011;8(1):47.
Species: Human
Sample Type: Serum

Thrombospondin-1 triggers cell migration and development of advanced prostate tumors.
Authors: Firlej V, Mathieu JR, Gilbert C, Lemonnier L, Nakhle J, Gallou-Kabani C, Guarmit B, Morin A, Prevarskaya N, Delongchamps NB, Cabon F
Cancer Res., 2011;71(24):7649-58.
Species: Human
Sample Type: Cell Lysates

Alternatives to the use of fetal bovine serum: human platelet lysates as a serum substitute in cell culture media.
Authors: Rauch C, Feifel E, Amann EM, Spotl HP, Schennach H, Pfaller W, Gstraunthaler G
ALTEX, 2011;28(4):305-16.
Species: Human
Sample Type: Cell Lysates

Pertuzumab in combination with trastuzumab shows significantly enhanced antitumor activity in HER2-positive human gastric cancer xenograft models.
Authors: Yamashita-Kashima Y, Iijima S, Yorozu K, Furugaki K, Kurasawa M, Ohta M, Fujimoto-Ouchi K
Clin. Cancer Res., 2011;17(15):5060-70.
Species: Human
Sample Type: Tissue Homogenates

Macrophage infiltration predicts a poor prognosis for human ewing sarcoma.
Authors: Fujiwara T, Fukushi J, Yamamoto S, Matsumoto Y, Setsu N, Oda Y, Yamada H, Okada S, Watari K, Ono M, Kuwano M, Kamura S, Iida K, Okada Y, Koga M, Iwamoto Y
Am. J. Pathol., 2011;179(3):1157-70.
Species: Human
Sample Type: Cell Culture Supernates

In vitro vascular tube formation testing as a tool for treatment individualisation in patients with cervical cancer.
Authors: Landt S, Heidecke H, Korlach S, Reuter C, Schwidde I, Barinoff J, Thill M, Sehouli J, Kummel S
Anticancer Res., 2011;31(8):2609-15.
Species: Human
Sample Type: Serum

Serum levels of beta-catenin as a potential marker for genotype 4/hepatitis C-associated hepatocellular carcinoma.
Authors: Zekri A, Bahnassy A, Alam El-Din H, Morsy H, Shaarawy S, Moharram N, Daoud S
Oncol Rep, 2011;26(4):825-31.
Species: Human
Sample Type: Serum

Association of angiopoietin-2, C-reactive protein and markers of obesity and insulin resistance with survival outcome in colorectal cancer.
Authors: Volkova E, Willis JA, Wells JE, Robinson BA, Dachs GU, Currie MJ
Br. J. Cancer, 2011;104(1):51-9.
Species: Human
Sample Type: Serum

Leptin administered in physiological or pharmacological doses does not regulate circulating angiogenesis factors in humans.
Authors: Aronis KN, Diakopoulos KN, Fiorenza CG
Diabetologia, 2011;54(9):2358-67.
Species: Human
Sample Type: Serum

Endocrine gland-derived vascular endothelial growth factor concentrations in follicular fluid and serum may predict ovarian hyperstimulation syndrome in women undergoing controlled ovarian hyperstimulation.
Authors: Gao MZ, Zhao XM, Sun ZG
Fertil. Steril., 2011;95(2):673-8.
Species: Human
Sample Type: Serum

Prognostic significance of angiogenic factors in uterine cervical cancer.
Authors: Landt S, Wehling M, Heidecke H, Jeschke S, Korlach S, Stoblen F, Schmid P, Blohmer JU, Lichtenegger W, Sehouli J, Kummel S
Anticancer Res., 2011;31(8):2589-95.
Species: Human
Sample Type: Serum

Phase I and pharmacokinetic study of sunitinib in pediatric patients with refractory solid tumors: a children's oncology group study.
Authors: Dubois SG, Shusterman S, Ingle AM, Ahern CH, Reid JM, Wu B, Baruchel S, Glade-Bender J, Ivy P, Grier HE, Adamson PC, Blaney SM
Clin. Cancer Res., 2011;17(15):5113-22.
Species: Human
Sample Type: Plasma

Myeloid Biomarkers Associated with Glioblastoma Response to Anti-VEGF Therapy with Aflibercept.
Authors: de Groot JF, Piao Y, Tran H, Gilbert M, Wu HK, Liu J, Bekele BN, Cloughesy T, Mehta M, Robins HI, Lassman A, Deangelis L, Camphausen K, Chen A, Yung W, Prados M, Wen PY, Heymach JV
Clin. Cancer Res., 2011;17(14):4872-4881.
Species: Human
Sample Type: Plasma

Extended ischemia prevents HIF1alpha degradation at reoxygenation by impairing prolyl-hydroxylation: role of Krebs cycle metabolites.
Authors: Serra-Perez A, Planas AM, Núñez-O'Mara A, Berra E, Garcia-Villoria J, Ribes A, Santalucia T
J. Biol. Chem., 2010;285(24):18217-24.
Species: Human
Sample Type: Cell Culture Supernates

Differential effect of ischaemic preconditioning on mobilisation and recruitment of haematopoietic and mesenchymal stem cells in porcine myocardial ischaemia-reperfusion.
Authors: Gyongyosi M, Posa A, Pavo N, Hemetsberger R, Kvakan H, Steiner-Boker S, Petrasi Z, Manczur F, Pavo IJ, Edes IF, Wojta J, Glogar D, Huber K
Thromb. Haemost., 2010;104(2):376-84.
Species: Human
Sample Type: Plasma

Plasma haemoxygenase-1 in coronary artery disease. A comparison with angiogenin, matrix metalloproteinase-9, tissue inhibitor of metalloproteinase-1 and vascular endothelial growth factor.
Authors: Idriss NK, Lip GY, Balakrishnan B
Thromb. Haemost., 2010;104(5):1029-37.
Species: Human
Sample Type: Plasma

The transcription factor E2F1 and the SR protein SC35 control the ratio of pro-angiogenic versus antiangiogenic isoforms of vascular endothelial growth factor-A to inhibit neovascularization in vivo.
Authors: Merdzhanova G, Gout S, Keramidas M, Edmond V, Coll JL, Brambilla C, Brambilla E, Gazzeri S, Eymin B
Oncogene, 2010;29(39):5392-403.
Species: Human
Sample Type: Cell Culture Supernates

Defective angiogenesis in hypoplastic human fetal lungs correlates with nitric oxide synthase deficiency that occurs despite enhanced angiopoietin-2 and VEGF.
Authors: Boucherat O, Franco-Montoya ML, Delacourt C, Martinovic J, Masse V, Elie C, Thebaud B, Benachi A, Bourbon JR
Am. J. Physiol. Lung Cell Mol. Physiol., 2010;298(6):L849-56.
Species: Human
Sample Type: Tissue Homogenates

Dissecting the effects of lipopolysaccharides from nonlipopolysaccharide molecules in experimental porcine meningococcal sepsis.
Authors: Hellerud BC, Nielsen EW, Thorgersen EB, Lindstad JK, Pharo A, Tonnessen TI, Castellheim A, Mollnes TE, Brandtzaeg P
Crit. Care Med., 2010;38(6):1467-74.
Species: Porcine
Sample Type: Plasma

Human pregnancy specific beta-1-glycoprotein 1 (PSG1) has a potential role in placental vascular morphogenesis.
Authors: Ha CT, Wu JA, Irmak S, Lisboa FA, Dizon AM, Warren JW, Ergun S, Dveksler GS
Biol. Reprod., 2010;83(1):27-35.
Species: Human
Sample Type: Cell Culture Supernates

Signs of reduced angiogenic activity after surgical removal of deeply infiltrating endometriosis.
Authors: Bourlev V, Iljasova N, Adamyan L, Larsson A, Olovsson M
Fertil. Steril., 2010;94(1):52-7.
Species: Human
Sample Type: Serum

Soluble Flt-1 gene therapy ameliorates albuminuria but accelerates tubulointerstitial injury in diabetic mice.
Authors: Kosugi T, Nakayama T, Li Q, Chiodo VA, Zhang L, Campbell-Thompson M, Grant M, Croker BP, Nakagawa T
Am. J. Physiol. Renal Physiol., 2010;298(3):F609-16.
Species: Human
Sample Type: Serum

Cationic liposome coupled endostatin gene for treatment of peritoneal colon cancer.
Authors: Lan KL, Ou-Yang F, Yen SH, Shih HL, Lan KH
Clin. Exp. Metastasis, 2010;27(5):307-18.
Species: Human
Sample Type: Ascites

Sensitive plasma protein analysis by microparticle-based proximity ligation assays.
Authors: Darmanis S, Nong RY, Hammond M, Gu J, Alderborn A, Vanelid J, Siegbahn A, Gustafsdottir S, Ericsson O, Landegren U, Kamali-Moghaddam M
Mol. Cell Proteomics, 2010;9(2):327-35.
Species: Human
Sample Type: Plasma

Angiopoietin-2 plasma dosage predicts time to first treatment and overall survival in chronic lymphocytic leukemia.
Authors: Maffei R, Martinelli S, Santachiara R
Blood, 2010;116(4):584-92.
Species: Human
Sample Type: Plasma

Platelet-derived growth factor (PDGF)-PDGF receptor interaction activates bone marrow-derived mesenchymal stromal cells derived from chronic lymphocytic leukemia: implications for an angiogenic switch.
Authors: Ding W, Knox TR, Tschumper RC
Blood, 2010;116(16):2984-93.
Species: Human
Sample Type: Platelet-Poor Plasma

Distraction osteogenesis induces endothelial progenitor cell mobilization without inflammatory response in man.
Authors: Lee DY, Cho TJ, Lee HR, Park MS, Yoo WJ, Chung CY, Choi IH
Bone, 2010;46(3):673-9.
Species: Human
Sample Type: Plasma

CD14 inhibition efficiently attenuates early inflammatory and hemostatic responses in Escherichia coli sepsis in pigs.
Authors: Thorgersen EB, Hellerud BC, Nielsen EW, Barratt-Due A, Fure H, Lindstad JK, Pharo A, Fosse E, Tonnessen TI, Johansen HT, Castellheim A, Mollnes TE
FASEB J., 2010;24(3):712-22.
Species: Porcine
Sample Type: Plasma

A phase I trial of bortezomib with temozolomide in patients with advanced melanoma: toxicities, antitumor effects, and modulation of therapeutic targets.
Authors: Su Y, Amiri KI, Horton LW
Clin. Cancer Res., 2010;16(1):348-57.
Species: Human
Sample Type: Serum

Effect of intensive lifestyle changes on endothelial function and on inflammatory markers of atherosclerosis.
Authors: Dod HS, Bhardwaj R, Sajja V, Weidner G, Hobbs GR, Konat GW, Manivannan S, Gharib W, Warden BE, Nanda NC, Beto RJ, Ornish D, Jain AC
Am. J. Cardiol., 2010;105(3):362-7.
Species: Human
Sample Type: Serum

Placental growth factor neutralising antibodies give limited anti-angiogenic effects in an in vitro organotypic angiogenesis model.
Authors: Brave SR, Eberlein C, Shibuya M, Wedge SR, Barry ST
Angiogenesis, 2010;13(4):337-47.
Species: Human
Sample Type: Cell Culture Supernates

Inhibition of cancer cell proliferation and metastasis by insulin receptor downregulation.
Authors: Zhang H, Fagan DH, Zeng X
Oncogene, 2010;29(17):2517-27.
Species: Human
Sample Type: Cell Culture Supernates

Multiple receptor tyrosine kinases regulate HIF-1alpha and HIF-2alpha in normoxia and hypoxia in neuroblastoma: implications for antiangiogenic mechanisms of multikinase inhibitors.
Authors: Nilsson MB, Zage PE, Zeng L, Xu L, Cascone T, Wu HK, Saigal B, Zweidler-McKay PA, Heymach JV
Oncogene, 2010;29(20):2938-49.
Species: Human
Sample Type: Cell Culture Supernates

VEGF-A promotes lymphoma tumour growth by activation of STAT proteins and inhibition of p27(KIP1) via paracrine mechanisms.
Authors: Roorda BD, Ter Elst A, Scherpen FJ, Meeuwsen-de Boer TG, Kamps WA, de Bont ES
Eur. J. Cancer, 2010;46(5):974-82.
Species: Human
Sample Type: Plasma

Vascular endothelial growth factor as an autocrine survival factor for retinal pigment epithelial cells under oxidative stress via the VEGF-R2/PI3K/Akt.
Authors: Byeon SH, Lee SC, Choi SH, Lee HK, Lee JH, Chu YK, Kwon OW
Invest. Ophthalmol. Vis. Sci., 2010;51(2):1190-7.
Species: Human
Sample Type: Cell Culture Supernates

Inhibition of EGFR pathway signaling and the metastatic potential of breast cancer cells by PA-MSHA mediated by type 1 fimbriae via a mannose-dependent manner.
Authors: Liu ZB, Hou YF, Zhu J
Oncogene, 2010;29(20):2996-3009.
Species: Human
Sample Type: Cell Culture Supernates

The change of cytokines in tear and blood after different pterygium operation.
Authors: Lee JK, Song YS, Shin JS, Kwon YS, Shin MS, Kim JC
Cytokine, 2010;49(2):148-54.
Species: Human
Sample Type: Tears

Stromal cell-derived factor-1 is essential for photoreceptor cell protection in retinal detachment.
Authors: Otsuka H, Arimura N, Sonoda S
Am. J. Pathol., 2010;177(5):2268-77.
Species: Human
Sample Type: Vitreous Humor

Macrophage inhibitory cytokine-1 regulates melanoma vascular development.
Authors: Huh SJ, Chung CY, Sharma A
Am. J. Pathol., 2010;176(6):2948-57.
Species: Human
Sample Type: Serum

Vitreous VEGF clearance is increased after vitrectomy.
Authors: Lee SS, Ghosn C, Yu Z, Zacharias LC, Kao H, Lanni C, Abdelfattah N, Kuppermann B, Csaky KG, D'Argenio DZ, Burke JA, Hughes PM, Robinson MR
Invest. Ophthalmol. Vis. Sci., 2010;51(4):2135-8.
Species: Rabbit
Sample Type: Vitreous Humor

Phase 1/2 study of preoperative docetaxel and mitoxantrone for high-risk prostate cancer.
Authors: Garzotto M, Higano CS, O'Brien C, Rademacher BL, Janeba N, Fazli L, Lange PH, Lieberman S, Beer TM
Cancer, 2010;116(7):1699-708.
Species: Human
Sample Type: Plasma

VEGF-mediated angiogenesis stimulates neural stem cell proliferation and differentiation in the premature brain.
Authors: Sun J, Sha B, Zhou W, Yang Y
Biochem. Biophys. Res. Commun., 2010;394(1):146-52.
Species: Human
Sample Type: Cell Culture Supernates

Colorectal resection is associated with persistent proangiogenic plasma protein changes: postoperative plasma stimulates in vitro endothelial cell growth, migration, and invasion.
Authors: Shantha Kumara HM, Feingold D, Kalady M, Dujovny N, Senagore A, Hyman N, Cekic V, Whelan RL
Ann. Surg., 2009;249(6):973-7.
Species: Human
Sample Type: Plasma

Interleukin-32 promotes osteoclast differentiation but not osteoclast activation.
Authors: Mabilleau G, Sabokbar A
PLoS ONE, 2009;4(1):e4173.
Species: Human
Sample Type: Cell Culture Supernates

Differential regulation of VEGF after final oocyte maturation with GnRH agonist versus hCG: a rationale for OHSS reduction.
Authors: Cerrillo M, Rodriguez S, Mayoral M, Pacheco A, Martinez-Salazar J, Garcia-Velasco JA
Fertil. Steril., 2009;91(4):1526-8.
Species: Human
Sample Type: Plasma

A phase II trial of single agent bevacizumab in patients with relapsed, aggressive non-Hodgkin lymphoma: Southwest oncology group study S0108.
Authors: Stopeck AT, Unger JM, Rimsza LM, Bellamy WT, Iannone M, Persky DO, Leblanc M, Fisher RI, Miller TP
Leuk. Lymphoma, 2009;50(5):728-35.
Species: Human
Sample Type: Urine

Inhibition of complement and CD14 attenuates the Escherichia coli-induced inflammatory response in porcine whole blood.
Authors: Thorgersen EB, Pharo A, Haverson K, Axelsen AK, Gaustad P, Kotwal GJ, Sfyroera G, Mollnes TE
Infect. Immun., 2009;77(2):725-32.
Species: Porcine
Sample Type: Whole Blood

Cytokine secretion by human mesenchymal stem cells cocultured with damaged corneal epithelial cells.
Authors: Oh JY, Kim MK, Shin MS, Wee WR, Lee JH
Cytokine, 2009;46(1):100-3.
Species: Human
Sample Type: Cell Culture Supernates

Are plasma VEGF and its soluble receptor sFlt-1 atherogenic risk factors? Cross-sectional data from the SAPHIR study.
Authors: Sandhofer A, Tatarczyk T, Kirchmair R, Iglseder B, Paulweber B, Patsch JR, Schratzberger P
Atherosclerosis, 2009;206(1):265-9.
Species: Human
Sample Type: Plasma

Vascular endothelial growth factor drives autocrine epithelial cell proliferation and survival in chronic rhinosinusitis with nasal polyposis.
Authors: Lee HS, Myers A, Kim J
Am. J. Respir. Crit. Care Med., 2009;180(11):1056-67.
Species: Human
Sample Type: nasal lavage

生物活性

< 0.5% cross-reactivity observed with available related molecules.Cross-species reactivity observed with 1 or more species tested.
背景

VEGF (Vascular endothelial growth factor) is a potent mediator of both angiogenesis and vasculogenesis in the fetus and adult. It is required for regulating the proliferation, migration, and survival of embryonic endothelial cells and during wound healing and the female reproductive cycle in adults. Pathologically, it is involved in tumor development and tumor vascular leakage. VEGF binds to VEGF R1/Flt-1, VEGF R2/Flk-1/KDR, and Neuropilin-1. Multiple forms of VEGF are generated by alternative splicing and proteolysis.

参考文献
  • Adipocytokines
  • Adult Neurogenesis
  • Airway Inflammation and Remodeling
  • ALS Related Molecules
  • BIObrief: Neuroprotective & Pathogenic Effects of VEGF Signaling
  • Cancer Biomarkers
  • Developmental Factors Implicated in Neurodegeneration
  • HIF Transcription Factors
  • HIF-1 & Vascular Development
  • ICC / IHC Images: VEGF
  • Inflammatory Mediators
  • Macrophage Activation Markers
  • Mini-review: Vascular Endothelial Growth Factor (VEGF)
  • Myeloid-derived Suppressor Cells (MDSC)
  • New and Improved TNF Superfamily Proteins 2015
  • Platelets
  • Preeclampsia
  • Proliferation Bioassay HUVECs
  • Regulation of VE-Cadherin and VEGF R2 by VEGF
  • Technical Notes: Serum Levels of Vascular Growth Factors During Pregnancy
  • VEGF & Amyotrophic Lateral Sclerosis
  • VEGF Family
  • VEGF Family Ligands
  • VEGF, Angiopoietin-2 and Tumor Vascularization
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1.为保证数据质量,您需严格按要求准备样本和试剂:

1)血清、血浆、尿液、灌洗液、组织、细胞沉淀、裂解蛋白等,未经过反复冻融,且用量满足实验要求的最低标准。

2)组化实验组织样本,需经过10%中性缓冲福尔马林固定24-72小时后,转移到75%酒精中送样,且保证样品管上标记清晰,不会被酒精渗漏模糊掉字迹。

3)组化实验蜡块和切片样本,常温运输,尽可能使用盒子装蜡块,避免互相之前摩擦影响样本;切片使用切片盒放置,避免玻片之间相关刮创。

4)您必须明确说明提供给乙方的实验材料的安全性,确保无致病性、无传染性,对人、动植物和环境友好安全,以保证实验技术人员的安全。

5)珍贵样本,请您只提供满足实验服务合同的所需量,剩余样本自己保存好以免造成样本的浪费,耽误您的实验进展。

6)甲方任何样本准备过程中的疑问,均可以咨询乙方。或者发邮件至labex@univ-bio.com,或者拨打4008-168-068转3。

2.为保证实验准确性,您需知悉以下内容:

1)非试剂盒验证样本,存在检出率低的风险,客户知晓并同意的情况下,Labex配合开展实验。

2)检出率是在MSD标准曲线范围内的数据,样本内因子含量超出标准品检测范围的情况下:若低于MSD标准曲线范围,则无法检出;若超过标准品检测上限,需实进一步稀释样本优化实验。MSD技术是目前市场上检测范围最宽(横跨4-5log)的多因子检测技术,但蛋白质组几万种蛋白浓度横跨10 log,不能一概而论。

3.实验服务过程中样本和试剂运输要求:

1)您可自行送样(方式包括快递以及亲送)到我们指定地点,但过程中要保证正确的运输条件,干冰货物或冰袋运输务必保证干冰充足和冰袋低温。并及时通知到我们,方便我们接收。

您还需要准备一份随样单(合同附件所示),标注您的姓名、合同号、样本信息、试剂信息,随快递一起寄送。

若由于您运输条件的原因,导致实验结果问题,相关责任由您承担。

实验室接收样本联系方式,提供寄送咨询: labex@univ-bio.com4008-168-0683

2)若您需要我们协助寄送样本时,我们会收取合理的寄送费用,以我们标准合同上所列收费为准。

4.实验服务合同结束后样本和试剂处置须知:

请您下单前确定实验服务合同结束后,样本处置情况。我们将严格按照合同约定执行。若您选择实验结束后样本,不保留,丢弃,我们会在实验结束后按国家标准自行处置掉相关实验材料。若您需要回寄相关样本,在您支付一定的运输费用后,我们将剩余样本在规定时间内返还给您。若您选择到付,需要保证您的样本是常温和蓝冰运输的,更高要求的运输条件不支持货到付款。若您不确定是否回寄,我们将保持您的样本1个月的时间,如超期,样本我们将自行处置,不在另行通知您。 如果您选择我们回寄样本给您,我们将快递信息邮件告知您,由您跟踪物流信息,并及时确认。如因您个人原因或者第三方物流原因造成的样本邮寄过程中的损耗,我们不承担任何责任。

5.实验服务种实验服务数据:

1) 我们承诺按照《实验样本信息及要求》中的实验方案进行实验并提供客观实验结果,但由于科研实验中存在诸多不确定因素以及未知难度和风险而导致结果的不确定性,不能保证所有的实验进度和实验结果完全达到甲方预期。在排除实验操作问题导致不良结果的前提下,您应尊重客观事实,承担实验结果与预期不一致的结果,包括实验结果是阴性的风险。因此在得不到预期结果的情况下,您仍应支付本次实验服务的全部已发生费用。

2) 实验服务是由专业技术达标的实验人员,遵循科学实验方法和标准操作流程,依照服务合同完成,优宁维保证将客观真实科学严谨的实验结果给到客户,但单次实验不足以阐明某些复杂的科学问题。

3) 您在收到实验数据后,5个工作日内(荧光相关实验3个工作日内)对实验数据质量提质疑,我们有义务解答。若是我们实验过程中的问题,我们承担全部责任;若是您验设计问题,您承担全部责任。我们承诺1个月的数据复核期,欢迎后续咨询。

6.客户知识产权保密协议:

1) 实验服务过程中产生的实验数据的知识产权归您所有,我们承诺不得以任何形式向除甲方以外的第三方提供该实验数据。对于相关的实验技术所有权归我们所有,您不得主张权利。

2) 我们双方共同致力于维护对方的商业机密和技术机密,包括本次合同所签订的文件,您都有义务进行保密。

7.服务承诺

如由于实验客观性需要重复实验、自然灾害、政府行为或其他乙方无法预见、无法避免和无法克服等不可抗力的客观原因造成合同无法按期履行的,我们将及时通知甲方,双方将视情况决定是否继续履行合同。如果由于客观原因造成某些实验项目不能执行的,合同结束时,退回相应款项。

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