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Human IL-6 Quantikine ELISA Kit

(D6050)



概述
货号 D6050
描述

The Quantikine Human IL-6 Immunoassay is a 4.5 hour solid phase ELISA designed to measure IL-6 in cell culture supernates, serum, and plasma. It contains recombinant human IL-6 and antibodies raised against recombinant human IL-6 and has been shown to accurately quantitate the recombinant factor. Results obtained using natural IL-6 showed linear curves that were parallel to the standard curves obtained using the E. coli-expressed Quantikine kit standards. These results indicate that this kit can be used to determine relative mass values for natural human IL-6.

别名 B cell stimulatory factor-2; B-cell differentiation factor; BSF-2; BSF2CTL differentiation factor; CDF; HGFHSFIFNB2Hybridoma growth factor; IFN-beta 2; IFN-beta-2; IL-6B-cell stimulatory factor 2; Interferon beta-2; interleukin 6 (interferon, beta 2); interleukin BSF-2; interleukin-6; MGI-2A;
全称
Interleukin 6
反应种属 Human
形式 96-well strip plate
目标/特异性 Natural and recombinant human IL-6
性能
供应商 R&D Systems
检测类型 Solid Phase Sandwich ELISA
Entrez Gene IDs
3569 (Human); 16193 (Mouse); 24498 (Rat); 399500 (Porcine); 280826 (Bovine); 403985 (Canine); 100034196 (Equine); 493687 (Feline); 100008733 (Rabbit)
应用文献
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

Human lung fibroblasts may modulate dendritic cell phenotype and function: results from a pilot in vitro study
Authors: O Freynet, J Marchal-So, F Jean-Louis, A Mailleux, B Crestani, P Soler, L Michel
Respir Res, 2016;17(1):36.
Species: Human
Sample Type: Cell Culture Supernates

Pre-treatment neutrophil to lymphocyte ratio predicts the chemoradiotherapy outcome and survival in patients with oral squamous cell carcinoma: a retrospective study.
Authors: Nakashima H, Matsuoka Y, Yoshida R, Nagata M, Hirosue A, Kawahara K, Sakata J, Arita H, Hiraki A, Nakayama H
BMC Cancer, 2016;16(1):41.
Species: Human
Sample Type: Serum

A Novel IL6 Antibody Sensitizes Multiple Tumor Types to Chemotherapy Including Trastuzumab-Resistant Tumors.
Authors: Zhong H, Davis A, Ouzounova M, Carrasco R, Chen C, Breen S, Chang Y, Huang J, Liu Z, Yao Y, Hurt E, Moisan J, Fung M, Tice D, Clouthier S, Xiao Z, Wicha M, Korkaya H, Hollingsworth R
Cancer Res, 2016;76(2):480-90.
Species: Human
Sample Type: Cell Culture Supernates

Serum Interleukin-18, Fetuin-A, Soluble Intercellular Adhesion Molecule-1, and Endothelin-1 in Ankylosing Spondylitis, Psoriatic Arthritis, and SAPHO Syndrome
Int J Mol Sci, 2016;17(8):.
Species: Human
Sample Type: Serum

Stability of cytokines, chemokines and soluble activation markers in unprocessed blood stored under different conditions
Cytokine, 2016;84(0):17-24.
Species: Human
Sample Type: Plasma

Unexpected Normal Colloid Osmotic Pressure in Clinical States with Low Serum Albumin
PLoS ONE, 2016;11(7):e0159839.
Species: Human
Sample Type: Serum

P2X7 Receptor Inhibition Improves CD34 T-Cell Differentiation in HIV-Infected Immunological Nonresponders on c-ART
Authors: I Menkova-Ga, H Hocini, E Foucat, P Tisserand, L Bourdery, C Delaugerre, C Benne, Y Lévy, JD Lelièvre
PLoS Pathog, 2016;12(4):e1005571.
Species: Human
Sample Type: Plasma

Impact of periodontal intervention on local inflammation, periodontitis, and HIV outcomes
Authors: J Valentine, T Saladyanan, K Ramsey, J Blake, T Morelli, J Southerlan, EB Quinlivan, C Phillips, J Nelson, K DeParis, J Webster-Cy
Oral Dis, 2016;0(0):87-97.
Species: Human
Sample Type: Saliva

Association between mannose-binding lectin variants, haplotypes and risk of hepatocellular carcinoma: A case-control study
Sci Rep, 2016;6(0):32147.
Species: Human
Sample Type: Plasma

Innovative Flow Cytometry Allows Accurate Identification of Rare Circulating Cells Involved in Endothelial Dysfunction
PLoS ONE, 2016;11(8):e0160153.
Species: Human
Sample Type: Plasma

Bacteroides are associated with GALT iNKT cell function and reduction of microbial translocation in HIV-1 infection
Authors: D Paquin-Pro, C Ching, I Vujkovic-C, D Fadrosh, L Loh, Y Huang, M Somsouk, SV Lynch, PW Hunt, DF Nixon, D SenGupta
Mucosal Immunol, 2016;0(0):.
Species: Human
Sample Type: Plasma

Modulation of Endothelial Inflammation by Low and High Magnitude Cyclic Stretch
PLoS ONE, 2016;11(4):e0153387.
Species: Human
Sample Type: Cell Culture Supernates

Simple Plex() : A Novel Multi-Analyte, Automated Microfluidic Immunoassay Platform for the Detection of Human and Mouse Cytokines and Chemokines.
Authors: Aldo P, Marusov G, Svancara D, David J, Mor G
Am J Reprod Immunol, 2016;75(6):678-93.
Species: Human
Sample Type: Plasma

Nuclear DNA damage-triggered NLRP3 inflammasome activation promotes UVB-induced inflammatory responses in human keratinocytes
Authors: Tatsuya Hasegawa
Biochem Biophys Res Commun, 2016;0(0):.
Species: Human
Sample Type: Cell Culture Supernates

Association between Sleep Duration, Insomnia Symptoms and Bone Mineral Density in Older Boston Puerto Rican Adults.
Authors: Niu J, Sahni S, Liao S, Tucker K, Dawson-Hughes B, Gao X
PLoS ONE, 2015;10(7):e0132342.
Species: Human
Sample Type: Serum

Phosphocholine-Modified Macromolecules and Canonical Nicotinic Agonists Inhibit ATP-Induced IL-1beta Release.
Authors: Hecker A, Kullmar M, Wilker S, Richter K, Zakrzewicz A, Atanasova S, Mathes V, Timm T, Lerner S, Klein J, Kaufmann A, Bauer S, Padberg W, Kummer W, Janciauskiene S, Fronius M, Schweda E, Lochnit G, Grau V
J Immunol, 2015;195(5):2325-34.
Species: Human
Sample Type: Cell Culture Supernates

Deleted in malignant brain tumors 1 (DMBT1) elicits increased VEGF and decreased IL-6 production in type II lung epithelial cells.
Authors: Muller H, Nagel C, Weiss C, Mollenhauer J, Poeschl J
BMC Pulm Med, 2015;15(0):32.
Species: Human
Sample Type: Cell Culture Supernates

An association between abnormal bone turnover, systemic inflammation, and osteoporosis in patients with chronic pancreatitis: a case-matched study.
Authors: Duggan S, Purcell C, Kilbane M, O'Keane M, McKenna M, Gaffney P, Ridgway P, Boran G, Conlon K
Am J Gastroenterol, 2015;110(2):336-45.
Species: Human
Sample Type: Serum

Serum levels of inflammatory markers in depressed elderly patients with diabetes and mild cognitive impairment.
Authors: Gorska-Ciebiada M, Saryusz-Wolska M, Borkowska A, Ciebiada M, Loba J
PLoS ONE, 2015;10(3):e0120433.
Species: Human
Sample Type: Serum

The effect of the decoy molecule PA401 on CXCL8 levels in bronchoalveolar lavage fluid of patients with cystic fibrosis.
Authors: McElvaney O, O'Reilly N, White M, Lacey N, Pohl K, Gerlza T, Bergin D, Kerr H, McCarthy C, O'Brien M, Adage T, Kungl A, Reeves E, McElvaney N
Mol Immunol, 2015;63(2):550-8.
Species: Human
Sample Type: BALF

A randomized, placebo controlled trial of omega-3 fatty acids in the treatment of young children with autism.
Authors: Mankad D, Dupuis A, Smile S, Roberts W, Brian J, Lui T, Genore L, Zaghloul D, Iaboni A, Marcon P, Anagnostou E
Mol Autism, 2015;6(0):18.
Species: Human
Sample Type: Plasma

The N terminus of type III secretion needle protein YscF from Yersinia pestis functions to modulate innate immune responses.
Authors: Osei-Owusu P, Jessen Condry D, Toosky M, Roughead W, Bradley D, Nilles M
Infect Immun, 2015;83(4):1507-22.
Species: Human
Sample Type: Cell Culture Supernates

The Association between Serum Cytokines and Damage to Large and Small Nerve Fibers in Diabetic Peripheral Neuropathy.
Authors: Magrinelli F, Briani C, Romano M, Ruggero S, Toffanin E, Triolo G, Peter G, Praitano M, Lauriola M, Zanette G, Tamburin S
J Diabetes Res, 2015;2015(0):547834.
Species: Human
Sample Type: Serum

EphB4 Expressing Stromal Cells Exhibit an Enhanced Capacity for Hematopoietic Stem Cell Maintenance.
Authors: Nguyen T, Arthur A, Panagopoulos R, Paton S, Hayball J, Zannettino A, Purton L, Matsuo K, Gronthos S
Stem Cells, 2015;33(9):2838-49.
Species: Human
Sample Type: Cell Culture Supernates

Dietary Omega-3 Fatty Acid Supplementation Reduces Inflammation in Obese Pregnant Women: A Randomized Double-Blind Controlled Clinical Trial.
Authors: Haghiac M, Yang X, Presley L, Smith S, Dettelback S, Minium J, Belury M, Catalano P, Hauguel-De Mouzon S
PLoS ONE, 2015;10(9):e0137309.
Species: Human
Sample Type: Plasma

Increased FGF23 serum level is associated with unstable carotid plaque in type 2 diabetic subjects with internal carotid stenosis.
Authors: Biscetti F, Straface G, Porreca C, Bertoletti G, Vincenzoni C, Snider F, Stigliano E, Arena V, Angelini F, Pecorini G, Bianchi A, Landolfi R, Flex A
Cardiovasc Diabetol, 2015;14(0):139.
Species: Human
Sample Type: Serum

The ATP Receptors P2X7 and P2X4 Modulate High Glucose and Palmitate-Induced Inflammatory Responses in Endothelial Cells.
Authors: Sathanoori R, Sward K, Olde B, Erlinge D
PLoS ONE, 2015;10(5):e0125111.
Species: Human
Sample Type: Cell Culture Supernates

MyD88-Dependent Signaling Decreases the Antitumor Efficacy of Epidermal Growth Factor Receptor Inhibition in Head and Neck Cancer Cells.
Authors: Koch A, Love-Homan L, Espinosa-Cotton M, Stanam A, Simons A
Cancer Res, 2015;75(8):1657-67.
Species: Human
Sample Type: Cell Culture Supernates

A Dietary Supplement Containing Cinnamon, Chromium and Carnosine Decreases Fasting Plasma Glucose and Increases Lean Mass in Overweight or Obese Pre-Diabetic Subjects: A Randomized, Placebo-Controlled Trial.
Authors: Liu Y, Cotillard A, Vatier C, Bastard J, Fellahi S, Stevant M, Allatif O, Langlois C, Bieuvelet S, Brochot A, Guilbot A, Clement K, Rizkalla S
PLoS ONE, 2015;10(9):e0138646.
Species: Human
Sample Type: Plasma

Autophagy facilitates TLR4- and TLR3-triggered migration and invasion of lung cancer cells through the promotion of TRAF6 ubiquitination.
Authors: Zhan Z, Xie X, Cao H, Zhou X, Zhang X, Fan H, Liu Z
Autophagy, 2014;10(2):257-68.
Species: Human
Sample Type: Cell Culture Supernates

Metabolic implications when employing heavy pre- and post-exercise rapid-acting insulin reductions to prevent hypoglycaemia in type 1 diabetes patients: a randomised clinical trial.
Authors: Campbell M, Walker M, Trenell M, Luzio S, Dunseath G, Tuner D, Bracken R, Bain S, Russell M, Stevenson E, West D
PLoS ONE, 2014;9(5):e97143.
Species: Human
Sample Type: Serum

Prostate stromal cells express the progesterone receptor to control cancer cell mobility.
Authors: Yu, Yue, Lee, Jennifer, Xie, Ning, Li, Estelle, Hurtado-Coll, Antonio, Fazli, Ladan, Cox, Michael, Plymate, Stephen, Gleave, Martin, Dong, Xuesen
PLoS ONE, 2014;9(3):e92714.
Species: Human
Sample Type: Cell Culture Supernates

Osteosarcoma cells promote the production of pro-tumor cytokines in mesenchymal stem cells by inhibiting their osteogenic differentiation through the TGF-beta/Smad2/3 pathway.
Authors: Tu B, Peng Z, Fan Q, DU L, Yan W, Tang T
Exp Cell Res, 2014;320(1):164-73.
Species: Human
Sample Type: cell culture supernate

Phosphoproteomic profiling reveals IL6-mediated paracrine signaling within the Ewing sarcoma family of tumors.
Authors: Anderson J, Titz B, Akiyama R, Komisopoulou E, Park A, Tap W, Graeber T, Denny C
Mol Cancer Res, 2014;12(12):1740-54.
Species: Human
Sample Type: Cell Culture Supernates

OPG/RANKL/RANK axis is a critical inflammatory signaling system in ischemic brain in mice.
Authors: Shimamura M, Nakagami H, Osako M, Kurinami H, Koriyama H, Zhengda P, Tomioka H, Tenma A, Wakayama K, Morishita R
Proc Natl Acad Sci U S A, 2014;111(22):8191-6.
Species: Mouse
Sample Type: Cell Culture Supernates

WNT5A induces release of exosomes containing pro-angiogenic and immunosuppressive factors from malignant melanoma cells.
Authors: Ekstrom E, Bergenfelz C, von Bulow V, Serifler F, Carlemalm E, Jonsson G, Andersson T, Leandersson K
Mol Cancer, 2014;13(0):88.
Species: Human
Sample Type: Cell Culture Supernates

Analysis of plasma cytokines and angiogenic factors in patients with pretreated urothelial cancer receiving Pazopanib: the role of circulating interleukin-8 to enhance the prognostic accuracy.
Authors: Necchi A, Pennati M, Zaffaroni N, Landoni E, Giannatempo P, Raggi D, Schwartz L, Morosi C, Crippa F, Fare E, Nicolai N, Lanocita R, Sava T, Sacco C, Messina C, Ortega C, De Braud F, Salvioni R, Daidone M, Gianni A, Mariani L
Br J Cancer, 2014;110(1):26-33.
Species: Human
Sample Type: Plasma

Vitamin D insufficiency and subclinical atherosclerosis in non-diabetic males living with HIV.
Authors: Portilla J, Moreno-Perez O, Serna-Candel C, Escoin C, Alfayate R, Reus S, Merino E, Boix V, Giner L, Sanchez-Paya J, Pico A
J Int AIDS Soc, 2014;17(0):18945.
Species: Human
Sample Type: Serum

Mucosal biomarkers of colorectal cancer risk do not increase at 6 months following sleeve gastrectomy, unlike gastric bypass.
Authors: Kant P, Perry S, Dexter S, Race A, Loadman P, Hull M
Obesity (Silver Spring), 2014;22(1):202-10.
Species: Human
Sample Type: Serum

Decreased IL-7 responsiveness is related to oxidative stress in HIV disease.
Authors: Kalinowska M, Bazdar D, Lederman M, Funderburg N, Sieg S
PLoS ONE, 2013;8(3):e58764.
Species: Human
Sample Type: Serum

Reference range and short- and long-term biological variation of interleukin (IL)-6, IL-17A and tissue necrosis factor-alpha using high sensitivity assays.
Authors: Todd J, Simpson P, Estis J, Torres V, Wub A
Cytokine, 2013;64(3):660-5.
Species: Human
Sample Type: Plasma

Cleaved/associated TLR3 represents the primary form of the signaling receptor.
Authors: Toscano F, Estornes Y, Virard F, Garcia-Cattaneo A, Pierrot A, Vanbervliet B, Bonnin M, Ciancanelli M, Zhang S, Funami K, Seya T, Matsumoto M, Pin J, Casanova J, Renno T, Lebecque S
J Immunol, 2013;190(2):764-73.
Species: Human
Sample Type: cell culture supernate

HCMV activates the IL-6-JAK-STAT3 axis in HepG2 cells and primary human hepatocytes.
Authors: Lepiller Q, Abbas W, Kumar A, Tripathy M, Herbein G
PLoS ONE, 2013;8(3):e59591.
Species: Human
Sample Type: Cell Culture Supernates

EGFR inhibition induces proinflammatory cytokines via NOX4 in HNSCC.
Authors: Fletcher E, Love-Homan L, Sobhakumari A, Feddersen C, Koch A, Goel A, Simons A
Mol Cancer Res, 2013;11(12):1574-84.
Species: Human
Sample Type: Cell Culture Supernates

Protein carbamylation predicts mortality in ESRD.
Authors: Koeth R, Kalantar-Zadeh K, Wang Z, Fu X, Tang W, Hazen S
, 2013;0(0):.
Species: Human
Sample Type: Serum

Opium addiction increases interleukin 1 receptor antagonist (IL-1Ra) in the coronary artery disease patients.
Authors: Saadat, Habiboll, Ziai, Seyed Al, Ghanemnia, Maryam, Namazi, Mohammad, Safi, Morteza, Vakili, Hosein, Dabbagh, Ali, Gholami, Omid
PLoS ONE, 2012;7(9):e44939.
Species: Human
Sample Type: Plasma

Stimulated in vivo synthesis of plasminogen activator inhibitor-1 in human adipose tissue.
Authors: Ekstrom M, Liska J, Eriksson P, Sverremark-Ekstrom E, Tornvall P
Thromb Haemost, 2012;108(3):485-92.
Species: Human
Sample Type: Plasma

Cytomegalovirus impairs cytotrophoblast-induced lymphangiogenesis and vascular remodeling in an in vivo human placentation model.
Authors: Tabata T, Petitt M, Fang-Hoover J, Rivera J, Nozawa N, Shiboski S, Inoue N, Pereira L
Am J Pathol, 2012;181(5):1540-59.
Species: Human
Sample Type: Cell Culture Supernates

Engulfment of hematopoietic stem cells caused by down-regulation of CD47 is critical in the pathogenesis of hemophagocytic lymphohistiocytosis.
Authors: Kuriyama T, Takenaka K, Kohno K, Yamauchi T, Daitoku S, Yoshimoto G, Kikushige Y, Kishimoto J, Abe Y, Harada N, Miyamoto T, Iwasaki H, Teshima T, Akashi K
Blood, 2012;120(19):4058-67.
Species: Human
Sample Type: Serum

Mycobacterium bovis bacilli Calmette-Guerin regulates leukocyte recruitment by modulating alveolar inflammatory responses.
Authors: Andersson M, Lutay N, Hallgren O, Westergren-Thorsson G, Svensson M, Godaly G
Innate Immun, 2012;18(3):531-40.
Species: Human
Sample Type: Cell Culture Supernates

IL-33 promotes the migration and proliferation of circulating fibrocytes from patients with allergen-exacerbated asthma.
Authors: Bianchetti L, Marini M, Isgro M, Bellini A, Schmidt M, Mattoli S
Biochem Biophys Res Commun, 2012;426(1):116-21.
Species: Human
Sample Type: Cell Culture Supernates

CD4 T follicular helper cell dynamics during SIV infection.
J. Clin. Invest., 2012;122(9):3281-94.
Species: Primate - Macaca mulatta (Rhesus monkey)
Sample Type: Plasma

Anti-arthritic effects of magnolol in human interleukin 1β-stimulated fibroblast-like synoviocytes and in a rat arthritis model.
Authors: Wang JH, Shih KS, Liou JP, Wu YW, Chang AS, Wang KL, Tsai CL, Yang CR
PLoS ONE, 2012;7(2):e31368.
Species: Human
Sample Type: Cell Culture Supernates

A dynamic inflammatory cytokine network in the human ovarian cancer microenvironment.
Authors: Kulbe H, Chakravarty P, Leinster DA, Charles KA, Kwong J, Thompson RG, Coward JI, Schioppa T, Robinson SC, Gallagher WM, Galletta L, Salako MA, Smyth JF, Hagemann T, Brennan DJ, Bowtell DD, Balkwill FR
Cancer Res., 2012;72(1):66-75.
Species: Human
Sample Type: Cell Culture Supernates

A randomized trial of recombinant human granulocyte-macrophage colony stimulating factor for patients with acute lung injury.
Authors: Paine R, Standiford TJ, Dechert RE, Moss M, Martin GS, Rosenberg AL, Thannickal VJ, Burnham EL, Brown MB, Hyzy RC
Crit. Care Med., 2012;40(1):90-7.
Species: Human
Sample Type: BALF

A galectin-3-dependent pathway upregulates interleukin-6 in the microenvironment of human neuroblastoma.
Authors: Silverman A, Nakata R, Shimada H, Sposto R, DeClerck Y
Cancer Res, 2012;72(9):2228-38.
Species: Human
Sample Type: Cell Culture Supernates

Validation and quality control of ELISAs for the use with human saliva samples.
Authors: Jaedicke KM, Taylor JJ, Preshaw PM
J. Immunol. Methods, 2012;377(1):62-5.
Species: Human
Sample Type: Saliva

Compensated inflammation in systemic juvenile idiopathic arthritis: role of alternatively activated macrophages.
Authors: Shimizu M, Yachie A
Cytokine, 2012;60(1):226-32.
Species: Human
Sample Type: Serum

Adiponectin induces CCL20 expression synergistically with IL-6 and TNF-alpha in THP-1 macrophages.
Authors: Suzuki M, Mihara M
Cytokine, 2012;58(3):344-50.
Species: Human
Sample Type: Cell Culture Supernates

TBK1-associated protein in endolysosomes (TAPE)/CC2D1A is a key regulator linking RIG-I-like receptors to antiviral immunity.
Authors: Chen K, Chang C, Huang C, Lin C, Lin W, Lo Y, Yang C, Hsing E, Chen L, Shih S, Shiau A, Lei H, Tan T, Ling P
J Biol Chem, 2012;287(38):32216-21.
Species: Mouse
Sample Type: Cell Culture Supernates

Inflammation marker and risk of pancreatic cancer: a nested case-control study within the EPIC cohort.
Authors: Grote VA, Kaaks R, Nieters A, Tjonneland A, Halkjaer J, Overvad K, Skjelbo Nielsen MR, Boutron-Ruault MC, Clavel-Chapelon F, Racine A, Teucher B, Becker S, Pischon T, Boeing H, Trichopoulou A, Cassapa C, Stratigakou V, Palli D, Krogh V, Tumino R, Vineis P, Panico S, Rodriguez L, Duell EJ, Sanchez MJ, Dorronsoro M, Navarro C, Gurrea AB, Siersema PD, Peeters PH, Ye W, Sund M, Lindkvist B, Johansen D, Khaw KT, Wareham N, Allen NE, Travis RC, Fedirko V, Jenab M, Michaud DS, Chuang SC, Romaguera D, Bueno-de-Mesquita HB, Rohrmann S
Br. J. Cancer, 2012;106(11):1866-74.
Species: Human
Sample Type: Plasma

Inflammation associated with obesity: relationship with blood and bone marrow endothelial cells.
Authors: McGuire TR, Brusnahan SK, Bilek LD, Jackson JD, Kessinger MA, Berger AM, Garvin KL, O'Kane BJ, Tuljapurkar SR, Sharp JG
Obesity (Silver Spring), 2011;19(11):2130-6.
Species: Human
Sample Type: Plasma

Curcumin treatment suppresses IKKbeta kinase activity of salivary cells of patients with head and neck cancer: a pilot study.
Authors: Kim SG, Veena MS, Basak SK, Han E, Tajima T, Gjertson DW, Starr J, Eidelman O, Pollard HB, Srivastava M, Srivatsan ES, Wang MB
Clin. Cancer Res., 2011;17(18):5953-61.
Species: Human
Sample Type: Saliva

Increased prevalence of albuminuria in HIV-infected adults with diabetes.
Authors: Kim PS, Woods C, Dutcher L, Georgoff P, Rosenberg A, Mican JA, Kopp JB, Smith MA, Hadigan C
PLoS ONE, 2011;6(9):e24610.
Species: Human
Sample Type: Serum

Cyclooxygenase-2 inhibitor blocks the production of West Nile virus-induced neuroinflammatory markers in astrocytes.
Authors: Verma S, Kumar M, Nerurkar VR
J. Gen. Virol., 2011;92(0):507-15.
Species: Human
Sample Type: Cell Culture Supernates

p38MAPK is a novel DNA damage response-independent regulator of the senescence-associated secretory phenotype.
Authors: Freund A, Patil CK, Campisi J
EMBO J., 2011;30(8):1536-48.
Species: Human
Sample Type: Cell Culture Supernates

Upregulation of lipocalin 2 in adipose tissues of severely obese women: positive relationship with proinflammatory cytokines.
Authors: Auguet T, Quintero Y, Terra X, Martinez S, Lucas A, Pellitero S, Aguilar C, Hernandez M, Del Castillo D, Richart C
Obesity (Silver Spring), 2011;19(12):2295-300.
Species: Human
Sample Type: Serum

Kinetics of circulating Th17 cytokines and adipokines in psoriasis patients.
Authors: Nakajima H, Nakajima K, Tarutani M, Morishige R, Sano S
Arch. Dermatol. Res., 2011;303(6):451-5.
Species: Human
Sample Type: Serum

HDAC inhibition by LBH589 affects the phenotype and function of human myeloid dendritic cells.
Authors: Song W, Tai YT, Tian Z, Hideshima T, Chauhan D, Nanjappa P, Exley MA, Anderson KC, Munshi NC
Leukemia, 2011;25(1):161-8.
Species: Human
Sample Type: Cell Culture Supernates

Exenatide affects circulating cardiovascular risk biomarkers independently of changes in body composition.
Authors: Bunck MC, Diamant M, Eliasson B, Corner A, Shaginian RM, Heine RJ, Taskinen MR, Yki-Jarvinen H, Smith U
Diabetes Care, 2010;33(8):1734-7.
Species: Human
Sample Type: Serum

Phagocytosis of apoptotic cells modulates mesenchymal stem cells osteogenic differentiation to enhance IL-17 and RANKL expression on CD4+ T cells.
Authors: Tso GH, Law HK, Tu W
Stem Cells, 2010;28(5):939-54.
Species: Human
Sample Type: Cell Culture Supernates

IL-33 mediates inflammatory responses in human lung tissue cells.
Authors: Yagami A, Orihara K, Morita H
J. Immunol., 2010;185(10):5743-50.
Species: Human
Sample Type: Cell Culture Supernates

Presence of IL-5 protein and IgE antibodies to staphylococcal enterotoxins in nasal polyps is associated with comorbid asthma.
Authors: Bachert C, Zhang N, Holtappels G, De Lobel L, Van Cauwenberge P, Liu S, Lin P, Bousquet J, Van Steen K
J. Allergy Clin. Immunol., 2010;126(5):962.
Species: Human
Sample Type: Tissue Homogenates

Prehospital resuscitation with hypertonic saline-dextran modulates inflammatory, coagulation and endothelial activation marker profiles in severe traumatic brain injured patients.
Authors: Rhind SG, Crnko NT, Baker AJ
J Neuroinflammation, 2010;7(0):5.
Species: Human
Sample Type: Serum

Serum IP-10 as a biomarker of human rhinovirus infection at exacerbation of COPD.
Authors: Quint JK, Donaldson GC, Goldring JJ, Baghai-Ravary R, Hurst JR, Wedzicha JA
Chest, 2010;137(4):812-22.
Species: Human
Sample Type: Serum

Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion.
Authors: Rodier F, Coppe JP, Patil CK, Hoeijmakers WA, Munoz DP, Raza SR, Freund A, Campeau E, Davalos AR, Campisi J
Nat. Cell Biol., 2009;11(8):973-9.
Species: Human
Sample Type: Cell Culture Supernates

Interleukin-32 promotes osteoclast differentiation but not osteoclast activation.
Authors: Mabilleau G, Sabokbar A
PLoS ONE, 2009;4(1):e4173.
Species: Human
Sample Type: Cell Culture Supernates

Functional coexpression of Interleukin (IL)-7 and its receptor (IL-7R) on Hodgkin and Reed-Sternberg cells: Involvement of IL-7 in tumor cell growth and microenvironmental interactions of Hodgkin's lymphoma.
Authors: Cattaruzza L, Gloghini A, Olivo K, Di Francia R, Lorenzon D, De Filippi R, Carbone A, Colombatti A, Pinto A, Aldinucci D
Int. J. Cancer, 2009;125(5):1092-101.
Species: Human
Sample Type: Cell Culture Supernates

Adiponectin upregulates monocytic activin A but systemic levels are not altered in obesity or type 2 diabetes.
Authors: Weigert J, Neumeier M, Wanninger J, Schober F, Sporrer D, Weber M, Schramm A, Wurm S, Stogbauer F, Filarsky M, Schaffler A, Aslanidis C, Scholmerich J, Buechler C
Cytokine, 2009;45(2):86-91.
Species: Human
Sample Type: Plasma

Hyperbaric oxygen causes both antiinflammation and antipyresis in rabbits.
Authors: Niu KC, Huang WT, Lin MT, Huang KF
Eur. J. Pharmacol., 2009;606(1):240-5.
Species: Rabbit
Sample Type: Serum

Prostate cancer promotes CD11b positive cells to differentiate into osteoclasts.
Authors: Mizutani K, Sud S, Pienta KJ
J. Cell. Biochem., 2009;106(4):563-9.
Species: Human
Sample Type: Cell Culture Supernates

Immuno-inflammatory and thrombotic/fibrinolytic variables associated with acute ischemic stroke diagnosis.
Authors: Tuttolomondo A, Pinto A, Corrao S, Di Raimondo D, Fernandez P, Di Sciacca R, Arnao V, Licata G
Atherosclerosis, 2009;203(2):503-8.
Species: Human
Sample Type: Plasma

Interleukin-6 in the bone marrow microenvironment promotes the growth and survival of neuroblastoma cells.
Authors: Ara T, Song L, Shimada H, Keshelava N, Russell HV, Metelitsa LS, Groshen SG, Seeger RC, DeClerck YA
Cancer Res., 2009;69(1):329-37.
Species: Human
Sample Type: Serum

Urinary proinflammatory cytokine response in renal transplant recipients with polyomavirus BK viruria.
Authors: Sadeghi M, Daniel V, Schnitzler P, Lahdou I, Naujokat C, Zeier M, Opelz G
Transplantation, 2009;88(9):1109-16.
Species: Human
Sample Type: Urine

Direct and indirect impairment of human dendritic cell function by virulent Francisella tularensis Schu S4.
Authors: Chase JC, Celli J, Bosio CM
Infect. Immun., 2009;77(1):180-95.
Species: Human
Sample Type: Cell Culture Supernates

Inflammatory interaction between LIGHT and proteinase-activated receptor-2 in endothelial cells: potential role in atherogenesis.
Authors: Sandberg WJ, Halvorsen B, Yndestad A, Smith C, Otterdal K, Brosstad FR, Froland SS, Olofsson PS, Damas JK, Gullestad L, Hansson GK, Oie E, Aukrust P
Circ. Res., 2009;104(1):60-8.
Species: Human
Sample Type: Cell Culture Supernates

Cerebrospinal fluid levels of interleukin-6 and interleukin-12 in children with meningitis.
Authors: Hsieh CC, Lu JH, Chen SJ, Lan CC, Chow WC, Tang RB
Cytotechnology, 2009;25(4):461-5.
Species: Human
Sample Type: CSF

Decoy receptor 3 levels in peripheral blood predict outcomes of acute respiratory distress syndrome.
Authors: Chen CY, Yang KY, Chen MY, Chen HY, Lin MT, Lee YC, Perng RP, Hsieh SL, Yang PC, Chou TY
Am. J. Respir. Crit. Care Med., 2009;180(8):751-60.
Species: Human
Sample Type: Plasma

Helicobacter pylori cytotoxin-associated gene A activates the signal transducer and activator of transcription 3 pathway in vitro and in vivo.
Authors: Bronte-Tinkew DM, Terebiznik M, Franco A, Ang M, Ahn D, Mimuro H, Sasakawa C, Ropeleski MJ, Peek RM, Jones NL
Cancer Res., 2009;69(2):632-9.
Species: Human
Sample Type: Cell Culture Supernates

Dexamethasone suppresses interleukin-22 associated with bacterial infection in vitro and in vivo.
Authors: Ziesche E, Scheiermann P, Bachmann M, Sadik CD, Hofstetter C, Zwissler B, Pfeilschifter J, Muhl H
Clin. Exp. Immunol., 2009;157(3):370-6.
Species: Human
Sample Type: Plasma

Soluble and membrane levels of molecules involved in the interaction between clonal plasma cells and the immunological microenvironment in multiple myeloma and their association with the characteristics of the disease.
Authors: Perez-Andres M, Almeida J, Martin-Ayuso M, De Las Heras N, Moro MJ, Martin-Nunez G, Galende J, Cuello R, Abuin I, Moreno I, Dominguez M, Hernandez J, Mateo G, San Miguel JF, Orfao A
Int. J. Cancer, 2009;124(2):367-75.
Species: Human
Sample Type: Plasma

HIV increases markers of cardiovascular risk: results from a randomized, treatment interruption trial.
Authors: Calmy A, Gayet-Ageron A, Montecucco F, Nguyen A, Mach F, Burger F, Ubolyam S, Carr A, Ruxungtham K, Hirschel B, Ananworanich J,
AIDS, 2009;23(8):929-39.
Species: Human
Sample Type: Plasma

Low-grade inflammation can partly explain the association between the metabolic syndrome and either coronary artery disease or severity of peripheral arterial disease: the CODAM study.
Authors: Jacobs M, van Greevenbroek MM, van der Kallen CJ, Ferreira I, Blaak EE, Feskens EJ, Jansen EH, Schalkwijk CG, Stehouwer CD
Eur. J. Clin. Invest., 2009;39(6):437-44.
Species: Human
Sample Type: Plasma

Smoking, inflammatory patterns and postprandial hypertriglyceridemia.
Authors: Kabagambe EK, Ordovas JM, Tsai MY, Borecki IB, Hopkins PN, Glasser SP, Arnett DK
Atherosclerosis, 2009;203(2):633-9.
Species: Human
Sample Type: Serum

Two large preoperative doses of erythropoietin do not reduce the systemic inflammatory response to cardiac surgery.
Authors: Poulsen TD, Andersen LW, Steinbruchel D, Gotze JP, Jorgensen OS, Olsen NV
J. Cardiothorac. Vasc. Anesth., 2009;23(3):316-23.
Species: Human
Sample Type: Plasma

Cytokine secretion by human mesenchymal stem cells cocultured with damaged corneal epithelial cells.
Authors: Oh JY, Kim MK, Shin MS, Wee WR, Lee JH
Cytokine, 2009;46(1):100-3.
Species: Human
Sample Type: Cell Culture Supernates

In vivo regulation of interleukin 1beta in patients with cryopyrin-associated periodic syndromes.
Authors: Lachmann HJ, Lowe P, Felix SD, Rordorf C, Leslie K, Madhoo S, Wittkowski H, Bek S, Hartmann N, Bosset S, Hawkins PN, Jung T
J. Exp. Med., 2009;206(5):1029-36.
Species: Human
Sample Type: Plasma

HLA-DR+ leukocytes acquire CD1 antigens in embryonic and fetal human skin and contain functional antigen-presenting cells.
Authors: Schuster C, Vaculik C, Fiala C, Meindl S, Brandt O, Imhof M, Stingl G, Eppel W, Elbe-Burger A
J. Exp. Med., 2009;206(1):169-81.
Species: Human
Sample Type: Cell Culture Supernates

Proteinase-activated receptor (PAR)-2 activation impacts bone resorptive properties of human osteoarthritic subchondral bone osteoblasts.
Authors: Amiable N, Tat SK, Lajeunesse D, Duval N, Pelletier JP, Martel-Pelletier J, Boileau C
Bone, 2009;44(6):1143-50.
Species: Human
Sample Type: Cell Culture Supernates

Time course of anemia during six months follow up following intensive care discharge and factors associated with impaired recovery of erythropoiesis.
Authors: Bateman AP, McArdle F, Walsh TS
Crit. Care Med., 2009;37(6):1906-12.
Species: Human
Sample Type: Serum

The novel lipopolysaccharide-binding protein CRISPLD2 is a critical serum protein to regulate endotoxin function.
Authors: Wang ZQ, Xing WM, Fan HH, Wang KS, Zhang HK, Wang QW, Qi J, Yang HM, Yang J, Ren YN, Cui SJ, Zhang X, Liu F, Lin DH, Wang WH, Hoffmann MK, Han ZG
J. Immunol., 2009;183(10):6646-56.
Species: Human
Sample Type: Cell Culture Supernates

Gender specific associations between matrix metalloproteinases and inflammatory markers in post myocardial infarction patients.
Authors: Samnegard A, Hulthe J, Silveira A, Ericsson CG, Hamsten A, Eriksson P
Atherosclerosis, 2009;202(2):550-6.
Species: Human
Sample Type: Plasma

Immunomodulation of nasal epithelial cells by Staphylococcus aureus-derived serine proteases.
Authors: Rudack C, Sachse F, Albert N, Becker K, von Eiff C
J. Immunol., 2009;183(11):7592-601.
Species: Human
Sample Type: Cell Culture Supernates

Human airway smooth muscle promotes human lung mast cell survival, proliferation, and constitutive activation: cooperative roles for CADM1, stem cell factor, and IL-6.
Authors: Hollins F, Kaur D, Yang W, Cruse G, Saunders R, Sutcliffe A, Berger P, Ito A, Brightling CE, Bradding P
J. Immunol., 2008;181(4):2772-80.
Species: Human
Sample Type: Cell Culture Supernates

Assessment of cervicovaginal cytokine levels following exposure to microbicide Nisin gel in rabbits.
Authors: Aranha CC, Gupta SM, Reddy KV
Cytokine, 2008;43(1):63-70.
Species: Rabbit
Sample Type: Cell Culture Supernates

Autologous antitumor activity by NK cells expanded from myeloma patients using GMP-compliant components.
Authors: Alici E, Sutlu T, Bjorkstrand B, Gilljam M, Stellan B, Nahi H, Quezada HC, Gahrton G, Ljunggren HG, Dilber MS
Blood, 2008;111(6):3155-62.
Species: Human
Sample Type: Cell Culture Supernates

Biological and technical variables affecting immunoassay recovery of cytokines from human serum and simulated vaginal fluid: a multicenter study.
Authors: Fichorova RN, Richardson-Harman N, Alfano M, Belec L, Carbonneil C, Chen S, Cosentino L, Curtis K, Dezzutti CS, Donoval B, Doncel GF, Donaghay M, Grivel JC, Guzman E, Hayes M, Herold B, Hillier S, Lackman-Smith C, Landay A, Margolis L, Mayer KH, Pasicznyk JM, Pallansch-Cokonis M, Poli G, Reichelderfer P, Roberts P, Rodriguez I, Saidi H, Sassi RR, Shattock R, Cummins JE
Anal. Chem., 2008;80(12):4741-51.
Species: Human
Sample Type: WHO 89/548 reference standard

NF-kappaB-dependent cytokines in saliva and serum from patients with oral lichen planus: a study in an ethnic Chinese population.
Authors: Zhang Y, Lin M, Zhang S, Wang Z, Jiang L, Shen J, Bai J, Gao F, Zhou M, Chen Q
Cytokine, 2008;41(2):144-9.
Species: Human
Sample Type: Serum

Improved prediction of disease relapse after radical prostatectomy through a panel of preoperative blood-based biomarkers.
Authors: Shariat SF, Karam JA, Walz J, Roehrborn CG, Montorsi F, Margulis V, Saad F, Slawin KM, Karakiewicz PI
Clin. Cancer Res., 2008;14(12):3785-91.
Species: Human
Sample Type: Plasma

Pharmacodynamics and Pharmacokinetics of the Novel Thrombopoietin Mimetic Peptide RWJ-800088 in Humans.
Authors: Liem-Moolenaar M, Cerneus D, Molloy C, End D, Brown K, de Kam M, Cohen A, van Hensbergen Y, Burggraaf J
2008;84(0):481.
Species: Human
Sample Type: Plasma

MMP-12 induces IL-8/CXCL8 secretion through EGFR and ERK1/2 activation in epithelial cells.
Authors: Le Quement C, Guenon I, Gillon JY, Lagente V, Boichot E
Am. J. Physiol. Lung Cell Mol. Physiol., 2008;294(6):L1076-84.
Species: Human
Sample Type: Cell Culture Supernates

Hypoxia induces leptin gene expression and secretion in human preadipocytes: differential effects of hypoxia on adipokine expression by preadipocytes.
Authors: Wang B, Wood IS, Trayhurn P
J. Endocrinol., 2008;198(1):127-34.
Species: Human
Sample Type: Cell Culture Supernates

Gene expression profiling of human skeletal muscle in response to stabilized weight loss.
Authors: Larrouy D, Barbe P, Valle C, Dejean S, Pelloux V, Thalamas C, Bastard JP, Le Bouil A, Diquet B, Clement K, Langin D, Viguerie N
Am. J. Clin. Nutr., 2008;88(1):125-32.
Species: Human
Sample Type: Plasma

In vivo transmigrated monocytes from patients with stable coronary artery disease have a reduced expression of CD11b.
Authors: Paulsson JM, Dadfar E, Held C, Jacobson SH, Lundahl J
Clin. Exp. Immunol., 2008;153(2):196-204.
Species: Human
Sample Type: blister fluid

Short communication: decreasing soluble CD30 and increasing IFN-gamma plasma levels are indicators of effective highly active antiretroviral therapy.
Authors: Sadeghi M, Susal C, Daniel V, Naujokat C, Zimmermann R, Huth-Kuhne A, Opelz G
AIDS Res. Hum. Retroviruses, 2007;23(7):886-90.
Species: Human
Sample Type: Plasma

Impairment of human NK cell cytotoxic activity and cytokine release by cigarette smoke.
Authors: Mian MF, Lauzon NM, Stampfli MR, Mossman KL, Ashkar AA
J. Leukoc. Biol., 2007;83(3):774-84.
Species: Human
Sample Type: Cell Culture Supernates

1, 25 Dihydroxyvitamin D3 modulated cytokine response in pulmonary tuberculosis.
Authors: Vidyarani M, Selvaraj P, Jawahar MS, Narayanan PR
Cytokine, 2007;40(2):128-34.
Species: Human
Sample Type: Cell Culture Supernates

Effects of darbepoetin-alpha on plasma pro-inflammatory cytokines, anti-inflammatory cytokine interleukin-10 and soluble Fas/Fas ligand system in anemic patients with chronic heart failure.
Authors: Kourea K, Parissis JT, Farmakis D, Panou F, Paraskevaidis I, Venetsanou K, Filippatos G, Kremastinos DT
Atherosclerosis, 2007;199(1):215-21.
Species: Human
Sample Type: Plasma

Human mesenchymal stem cells inhibit neutrophil apoptosis: a model for neutrophil preservation in the bone marrow niche.
Authors: Raffaghello L, Bianchi G, Bertolotto M, Montecucco F, Busca A, Dallegri F, Ottonello L, Pistoia V
Stem Cells, 2007;26(1):151-62.
Species: Human
Sample Type: Cell Culture Supernates

Tumor necrosis factor alpha as a new target for renal cell carcinoma: two sequential phase II trials of infliximab at standard and high dose.
Authors: Harrison ML, Obermueller E, Maisey NR, Hoare S, Edmonds K, Li NF, Chao D, Hall K, Lee C, Timotheadou E, Charles K, Ahern R, King DM, Eisen T, Corringham R, DeWitte M, Balkwill F, Gore M
J. Clin. Oncol., 2007;25(29):4542-9.
Species: Human
Sample Type: Plasma

Developmental differences in the responses of IL-6 and IL-13 transgenic mice exposed to hyperoxia.
Authors: Choo-Wing R, Nedrelow JH, Homer RJ, Elias JA, Bhandari V
Am. J. Physiol. Lung Cell Mol. Physiol., 2007;293(1):L142-50.
Species: Human
Sample Type: Tissue Homogenates

Muscle atrophy and hypertrophy signaling in patients with chronic obstructive pulmonary disease.
Authors: Doucet M, Russell AP, Leger B, Debigare R, Joanisse DR, Caron MA, LeBlanc P, Maltais F
Am. J. Respir. Crit. Care Med., 2007;176(3):261-9.
Species: Human
Sample Type: Plasma

Pilot study of rosiglitazone therapy in women with breast cancer: effects of short-term therapy on tumor tissue and serum markers.
Authors: Yee LD, Williams N, Wen P, Young DC, Lester J, Johnson MV, Farrar WB, Walker MJ, Povoski SP, Suster S, Eng C
Clin. Cancer Res., 2007;13(1):246-52.
Species: Human
Sample Type: Serum

Changes in plasma vascular endothelial growth factor, angiopoietins, and their receptors following surgery for breast cancer.
Authors: Caine GJ, Stonelake PS, Lip GY, Blann AD
Cancer Lett., 2007;248(1):131-6.
Species: Human
Sample Type: Plasma

Inactivated Sendai virus particles eradicate tumors by inducing immune responses through blocking regulatory T cells.
Authors: Kurooka M, Kaneda Y
Cancer Res., 2007;67(1):227-36.
Species: Human
Sample Type: Cell Culture Supernates

Interferon-beta and adhesion molecules (E-selectin and s-intracellular adhesion molecule-1) are detected in sera from patients with retinal vasculitis and are induced in retinal vascular endothelial cells by Toll-like receptor 3 signalling.
Authors: Lee MT, Hooper LC, Kump L, Hayashi K, Nussenblatt R, Hooks JJ, Detrick B
Clin. Exp. Immunol., 2007;147(1):71-80.
Species: Human
Sample Type: Serum

Panel of markers can accurately predict endometriosis in a subset of patients.
Authors: Seeber B, Sammel MD, Fan X, Gerton GL, Shaunik A, Chittams J, Barnhart KT
Fertil. Steril., 2007;89(5):1073-81.
Species: Human
Sample Type: Serum

Interaction between cytokines and sCD40L in patients with stable and unstable coronary syndromes.
Authors: Tousoulis D, Antoniades C, Nikolopoulou A, Koniari K, Vasiliadou C, Marinou K, Koumallos N, Papageorgiou N, Stefanadi E, Siasos G, Stefanadis C
Eur. J. Clin. Invest., 2007;37(8):623-8.
Species: Human
Sample Type: Serum

Newly recruited human monocytes have a preserved responsiveness towards bacterial peptides in terms of CD11b up-regulation and intracellular hydrogen peroxide production.
Authors: Dadfar E, Jacobson SH, Lundahl J
Clin. Exp. Immunol., 2007;148(3):573-82.
Species: Human
Sample Type: Serum

Angiopoietin-2 is increased in severe sepsis: correlation with inflammatory mediators.
Authors: Orfanos SE, Kotanidou A, Glynos C, Athanasiou C, Tsigkos S, Dimopoulou I, Sotiropoulou C, Zakynthinos S, Armaganidis A, Papapetropoulos A, Roussos C
Crit. Care Med., 2007;35(1):199-206.
Species: Human
Sample Type: Serum

Mesenchymal stem cell abnormalities in patients with multiple myeloma.
Authors: Garderet L, Mazurier C, Chapel A, Ernou I, Boutin L, Holy X, Gorin NC, Lopez M, Doucet C, Lataillade JJ
Leuk. Lymphoma, 2007;48(10):2032-41.
Species: Human
Sample Type: Cell Culture Supernates

Nitrosative stress predicts the presence and severity of nonalcoholic fatty liver at different stages of the development of insulin resistance and metabolic syndrome: possible role of vitamin A intake.
Authors: Musso G, Gambino R, De Michieli F, Biroli G, Premoli A, Pagano G, Bo S, Durazzo M, Cassader M
Am. J. Clin. Nutr., 2007;86(3):661-71.
Species: Human
Sample Type: Serum

The levels of steroid hormones and cytokines in individual follicles are not associated with the fertilization outcome after intracytoplasmic sperm injection.
Authors: Asimakopoulos B, Abu-Hassan D, Metzen E, Al-Hasani S, Diedrich K, Nikolettos N
Fertil. Steril., 2007;90(1):60-4.
Species: Human
Sample Type: Follicular Fluid

Glycerol monolaurate inhibits the effects of Gram-positive select agents on eukaryotic cells.
Authors: Peterson ML, Schlievert PM
Biochemistry, 2006;45(7):2387-97.
Species: Human
Sample Type: Cell Culture Supernates

The potential of adiponectin in driving arthritis.
Authors: Ehling A, Schaffler A, Herfarth H, Tarner IH, Anders S, Distler O, Paul G, Distler J, Gay S, Scholmerich J, Neumann E, Muller-Ladner U
J. Immunol., 2006;176(7):4468-78.
Species: Human
Sample Type: Cell Culture Supernates

Functional characterization of a soluble gp130 isoform and its therapeutic capacity in an experimental model of inflammatory arthritis.
Authors: Richards PJ, Nowell MA, Horiuchi S, McLoughlin RM, Fielding CA, Grau S, Yamamoto N, Ehrmann M, Rose-John S, Williams AS, Topley N, Jones SA
Arthritis Rheum., 2006;54(5):1662-72.
Species: Human
Sample Type: Serum

Induction of dendritic cell maturation by pertussis toxin and its B subunit differentially initiate Toll-like receptor 4-dependent signal transduction pathways.
Authors: Wang ZY, Yang D, Chen Q, Leifer CA, Segal DM, Su SB, Caspi RR, Howard ZO, Oppenheim JJ
Exp. Hematol., 2006;34(8):1115-24.
Species: Human
Sample Type: Cell Culture Supernates

The new IL-1 family member IL-1F8 stimulates production of inflammatory mediators by synovial fibroblasts and articular chondrocytes.
Authors: Magne D, Palmer G, Barton JL, Mezin F, Talabot-Ayer D, Bas S, Duffy T, Noger M, Guerne PA, Nicklin MJ, Gabay C
Arthritis Res. Ther., 2006;8(3):R80.
Species: Human
Sample Type: Cell Culture Supernates

Transmission of Mycobacterium tuberculosis undetected by tuberculin skin testing.
Authors: Anderson ST, Williams AJ, Brown JR, Newton SM, Simsova M, Nicol MP, Sebo P, Levin M, Wilkinson RJ, Wilkinson KA
Am. J. Respir. Crit. Care Med., 2006;173(9):1038-42.
Species: Human
Sample Type: Cell Culture Supernates

Celecoxib up-regulates the expression of the zeta chain of T cell receptor complex in tumor-infiltrating lymphocytes in human cervical cancer.
Authors: Ferrandina G, Ranelletti FO, Legge F, Salutari V, Martinelli E, Fattorossi A, Lorusso D, Zannoni G, Vellone V, Paglia A, Scambia G
Clin. Cancer Res., 2006;12(7):2055-60.
Species: Human
Sample Type: Serum

C-reactive protein and vascular cell adhesion molecule-1 as markers of severity in sickle cell disease.
Authors: Makis AC, Hatzimichael EC, Stebbing J, Bourantas KL
Arch. Intern. Med., 2006;166(3):366-8.
Species: Human
Sample Type: Plasma

Modulation of cytokine secretion by pentacyclic triterpenes from olive pomace oil in human mononuclear cells.
Authors: Marquez-Martin A, De La Puerta R, Fernandez-Arche A, Ruiz-Gutierrez V, Yaqoob P
Cytokine, 2006;36(5):211-7.
Species: Human
Sample Type: Cell Culture Supernates

Non-esterified fatty acid concentrations are independently associated with hepatic steatosis in obese subjects.
Authors: Holt HB, Wild SH, Wood PJ, Zhang J, Darekar AA, Dewbury K, Poole RB, Holt RI, Phillips DI, Byrne CD
Diabetologia, 2006;49(1):141-8.
Species: Human
Sample Type: Serum

Kinin receptor expression during Staphylococcus aureus infection.
Authors: Bengtson SH, Phagoo SB, Norrby-Teglund A, Pahlman L, Morgelin M, Zuraw BL, Leeb-Lundberg LM, Herwald H
Blood, 2006;108(6):2055-63.
Species: Human
Sample Type: Cell Culture Supernates

Microvascular endothelial cells increase proliferation and inhibit apoptosis of native human acute myelogenous leukemia blasts.
Authors: Hatfield K, Ryningen A, Corbascio M, Bruserud O
Int. J. Cancer, 2006;119(10):2313-21.
Species: Human
Sample Type: Cell Culture Supernates

Dental plaque, gingival inflammation, and elevated levels of interleukin-6 and cortisol in gingival crevicular fluid from women with stress-related depression and exhaustion.
Authors: Johannsen A, Rylander G, Soder B, Asberg M
J. Periodontol., 2006;77(8):1403-9.
Species: Human
Sample Type: Gingival Crevicular Fluid (GCF)

The apoptotic-cell receptor CR3, but not alphavbeta5, is a regulator of human dendritic-cell immunostimulatory function.
Authors: Skoberne M, Somersan S, Almodovar W, Truong T, Petrova K, Henson PM, Bhardwaj N
Blood, 2006;108(3):947-55.
Species: Human
Sample Type: Cell Culture Supernates

Influence of eotaxin 67G>A polymorphism on plasma eotaxin concentrations in myocardial infarction survivors and healthy controls.
Authors: Sheikine Y, Olsen B, Gharizadeh B, Jatta K, Tornvall P, Ghaderi M
Atherosclerosis, 2006;189(2):458-63.
Species: Human
Sample Type: Serum

Urine cytokines profile in renal transplant patients with asymptomatic bacteriuria.
Authors: Ciszek M, Paczek L, Bartlomiejczyk I, Mucha K

生物活性 < 0.5% cross-reactivity observed with available related molecules.< 50% cross-species reactivity observed with species tested.
背景

IL-6 (Interleukin-6) is a pleiotropic cytokine that acts in the acute phase reaction, inflammation, hematopoiesis, bone metabolism, and cancer progression. It contributes to chronic inflammation in obesity, insulin resistance, inflammatory bowel disease, arthritis, sepsis, and atherosclerosis. IL-6 signals through a receptor complex of IL-6 R alpha and gp130. gp130 is also a component of the receptors for CLC, CNTF, CT-1, IL-11, IL-27, LIF, and OSM. Soluble forms of IL-6 R alpha are generated by both alternative splicing and proteolytic cleavage. In a mechanism known as trans-signaling, complexes of soluble IL-6 and IL-6 R alpha elicit responses from gp130-expressing cells that lack cell surface IL-6 R alpha.

参考文献
  • Adipocytokines
  • Cancer Biomarkers
  • Conventional/Classical Dendritic Cells
  • Cytokines and Receptors in Allergy and Asthma
  • Cytokines and Receptors in Angiogenesis
  • Cytokines and Receptors in Tfh Cell Differentiation and Function
  • Diabetes
  • gamma delta T Cells
  • Glucose Homeostasis
  • Helper T (Th) Cells
  • HIF Transcription Factors
  • ICC / IHC Images: IL-6
  • IL-6 Family
  • Infectious Diseases
  • Inflammatory Mediators
  • Interactive Pathway: Adipocytokines & Insulin Signaling
  • Interactive Pathway: Th17 Differentiation
  • Macrophage Activation Markers
  • Mini-review: Interleukin 6
  • Mouse Obesity Antibody Array
  • Multiple Myeloma
  • Multiple Sclerosis and Myelin Related Molecules
  • Myeloid-derived Suppressor Cells (MDSC)
  • Neuroinflammation
  • Obesity
  • Plasmacytoid Dendritic Cells
  • Role of IL-6 in Energy Expenditure
  • T Cell Cytokine Signaling
  • Th17 Cells
  • Th22 Cells
  • Th9 Cells
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1)血清、血浆、尿液、灌洗液、组织、细胞沉淀、裂解蛋白等,未经过反复冻融,且用量满足实验要求的最低标准。

2)组化实验组织样本,需经过10%中性缓冲福尔马林固定24-72小时后,转移到75%酒精中送样,且保证样品管上标记清晰,不会被酒精渗漏模糊掉字迹。

3)组化实验蜡块和切片样本,常温运输,尽可能使用盒子装蜡块,避免互相之前摩擦影响样本;切片使用切片盒放置,避免玻片之间相关刮创。

4)您必须明确说明提供给乙方的实验材料的安全性,确保无致病性、无传染性,对人、动植物和环境友好安全,以保证实验技术人员的安全。

5)珍贵样本,请您只提供满足实验服务合同的所需量,剩余样本自己保存好以免造成样本的浪费,耽误您的实验进展。

6)甲方任何样本准备过程中的疑问,均可以咨询乙方。或者发邮件至labex@univ-bio.com,或者拨打4008-168-068转3。

2.为保证实验准确性,您需知悉以下内容:

1)非试剂盒验证样本,存在检出率低的风险,客户知晓并同意的情况下,Labex配合开展实验。

2)检出率是在MSD标准曲线范围内的数据,样本内因子含量超出标准品检测范围的情况下:若低于MSD标准曲线范围,则无法检出;若超过标准品检测上限,需实进一步稀释样本优化实验。MSD技术是目前市场上检测范围最宽(横跨4-5log)的多因子检测技术,但蛋白质组几万种蛋白浓度横跨10 log,不能一概而论。

3.实验服务过程中样本和试剂运输要求:

1)您可自行送样(方式包括快递以及亲送)到我们指定地点,但过程中要保证正确的运输条件,干冰货物或冰袋运输务必保证干冰充足和冰袋低温。并及时通知到我们,方便我们接收。

您还需要准备一份随样单(合同附件所示),标注您的姓名、合同号、样本信息、试剂信息,随快递一起寄送。

若由于您运输条件的原因,导致实验结果问题,相关责任由您承担。

实验室接收样本联系方式,提供寄送咨询: labex@univ-bio.com4008-168-0683

2)若您需要我们协助寄送样本时,我们会收取合理的寄送费用,以我们标准合同上所列收费为准。

4.实验服务合同结束后样本和试剂处置须知:

请您下单前确定实验服务合同结束后,样本处置情况。我们将严格按照合同约定执行。若您选择实验结束后样本,不保留,丢弃,我们会在实验结束后按国家标准自行处置掉相关实验材料。若您需要回寄相关样本,在您支付一定的运输费用后,我们将剩余样本在规定时间内返还给您。若您选择到付,需要保证您的样本是常温和蓝冰运输的,更高要求的运输条件不支持货到付款。若您不确定是否回寄,我们将保持您的样本1个月的时间,如超期,样本我们将自行处置,不在另行通知您。 如果您选择我们回寄样本给您,我们将快递信息邮件告知您,由您跟踪物流信息,并及时确认。如因您个人原因或者第三方物流原因造成的样本邮寄过程中的损耗,我们不承担任何责任。

5.实验服务种实验服务数据:

1) 我们承诺按照《实验样本信息及要求》中的实验方案进行实验并提供客观实验结果,但由于科研实验中存在诸多不确定因素以及未知难度和风险而导致结果的不确定性,不能保证所有的实验进度和实验结果完全达到甲方预期。在排除实验操作问题导致不良结果的前提下,您应尊重客观事实,承担实验结果与预期不一致的结果,包括实验结果是阴性的风险。因此在得不到预期结果的情况下,您仍应支付本次实验服务的全部已发生费用。

2) 实验服务是由专业技术达标的实验人员,遵循科学实验方法和标准操作流程,依照服务合同完成,优宁维保证将客观真实科学严谨的实验结果给到客户,但单次实验不足以阐明某些复杂的科学问题。

3) 您在收到实验数据后,5个工作日内(荧光相关实验3个工作日内)对实验数据质量提质疑,我们有义务解答。若是我们实验过程中的问题,我们承担全部责任;若是您验设计问题,您承担全部责任。我们承诺1个月的数据复核期,欢迎后续咨询。

6.客户知识产权保密协议:

1) 实验服务过程中产生的实验数据的知识产权归您所有,我们承诺不得以任何形式向除甲方以外的第三方提供该实验数据。对于相关的实验技术所有权归我们所有,您不得主张权利。

2) 我们双方共同致力于维护对方的商业机密和技术机密,包括本次合同所签订的文件,您都有义务进行保密。

7.服务承诺

如由于实验客观性需要重复实验、自然灾害、政府行为或其他乙方无法预见、无法避免和无法克服等不可抗力的客观原因造成合同无法按期履行的,我们将及时通知甲方,双方将视情况决定是否继续履行合同。如果由于客观原因造成某些实验项目不能执行的,合同结束时,退回相应款项。

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