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Human IFN-gamma DuoSet ELISA, 5 Plate

(DY285B-05)



概述
货号 DY285B-05
别名
全称 Interferon gamma
形式 96-well strip plate
目标/特异性 Please see the product datasheet
性能
供应商 R&D Systems
检测类型 Solid Phase Sandwich ELISA
Entrez Gene IDs 3458 (Human); 15978 (Mouse); 25712 (Rat); 396991 (Porcine); 281237 (Bovine); 403801 (Canine); 493965 (Feline);
应用文献
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

On the cytokine/chemokine network during Plasmodium vivax malaria: new insights to understand the disease
Authors: NS Hojo-Souza, DB Pereira, FS de Souza, TA de Oliveir, MS Cardoso, MS Tada, GM Zanini, DC Bartholome, RT Fujiwara, LL Bueno
Malar. J, 2017;16(1):42.
Species: Human
Sample Type: Plasma

Mumps Virus Induces Protein-Kinase-R-Dependent Stress Granules, Partly Suppressing Type III Interferon Production
PLoS ONE, 2016;11(8):e0161793.
Species: Human
Sample Type: Cell Culture Supernates

Bortezomib treatment sensitizes oncolytic HSV-1 treated tumors to NK cell immunotherapy
Clin Cancer Res, 2016;0(0):.
Species: Mouse
Sample Type: Serum

Dual Inhibition of Rip2 and IRAK1/4 Regulates IL-1? and IL-6 in Sarcoidosis Alveolar Macrophages and Peripheral Blood Mononuclear Cells
J Immunol, 2016;0(0):.
Species: Human
Sample Type: Cell Culture Supernates

Analysis of receptor tyrosine kinase genetics identifies two novel risk loci in GAS6 and PROS1 in Beh�et's disease
Sci Rep, 2016;6(0):26662.
Species: Human
Sample Type: Cell Culture Supernates

Reduced systemic and mycobacterial antigen-stimulated concentrations of IL-1? and IL-18 in tuberculous lymphadenitis
Cytokine, 2016;90(0):66-72.
Species: Human
Sample Type: Whole Blood Supernates

DNA Sensing via TLR-9 Constitutes a Major Innate Immunity Pathway Activated during Erythema Nodosum Leprosum
J Immunol, 2016;0(0):.
Species: Human
Sample Type: Cell Culture Supernates

Acanthamoeba castellanii (Genotype T4) Stimulates the Production of Interleukin-10 as well as Pro-inflammatory Cytokines in THP-1 Cells, Human Peripheral Blood Mononuclear Cells and Human Monocyte-Derived Macrophages
Infect Immun, 2016;0(0):.
Species: Human
Sample Type: Cell Culture Supernates

An Autocrine Cytokine/JAK/STAT-Signaling Induces Kynurenine Synthesis in Multidrug Resistant Human Cancer Cells.
Authors: Campia I, Buondonno I, Castella B, Rolando B, Kopecka J, Gazzano E, Ghigo D, Riganti C
PLoS ONE, 2015;10(5):e0126159.
Species: Human
Sample Type: Cell Culture Supernates

Priming of Human Resting NK Cells by Autologous M1 Macrophages via the Engagement of IL-1beta, IFN-beta, and IL-15 Pathways.
Authors: Mattiola I, Pesant M, Tentorio P, Molgora M, Marcenaro E, Lugli E, Locati M, Mavilio D
J Immunol, 2015;195(6):2818-28.
Species: Human
Sample Type: Cell Culture Supernates

UNC-45A Is a Nonmuscle Myosin IIA Chaperone Required for NK Cell Cytotoxicity via Control of Lytic Granule Secretion.
Authors: Iizuka Y, Cichocki F, Sieben A, Sforza F, Karim R, Coughlin K, Isaksson Vogel R, Gavioli R, McCullar V, Lenvik T, Lee M, Miller J, Bazzaro M
J Immunol, 2015;195(10):4760-70.
Species: Human
Sample Type: Cell Culture Supernates

B7H6-Specific Bispecific T Cell Engagers Lead to Tumor Elimination and Host Antitumor Immunity.
Authors: Wu M, Zhang T, Gacerez A, Coupet T, DeMars L, Sentman C
J Immunol, 2015;194(11):5305-11.

B7H6-specific chimeric antigen receptors lead to tumor elimination and host antitumor immunity.
Authors: Wu M, Zhang T, DeMars L, Sentman C
Gene Ther, 2015;22(8):675-84.

Interleukin-23 Receptor Gene Polymorphism May Enhance Expression of the IL-23 Receptor, IL-17, TNF-alpha and IL-6 in Behcet's Disease.
Authors: Jiang Z, Hennein L, Tao Y, Tao L
PLoS ONE, 2015;10(7):e0134632.
Species: Human
Sample Type: Cell Culture Supernates

Characterization of host and microbial determinants in individuals with latent tuberculosis infection using a human granuloma model.
Authors: Guirado E, Mbawuike U, Keiser T, Arcos J, Azad A, Wang S, Schlesinger L
MBio, 2015;6(1):e02537-14.
Species: Human
Sample Type: cell supernates

Phenotypic profiling of CD8(+) T cells during Plasmodium vivax blood-stage infection.
Authors: Hojo-Souza N, Pereira D, Passos L, Gazzinelli-Guimaraes P, Cardoso M, Tada M, Zanini G, Bartholomeu D, Fujiwara R, Bueno L
BMC Infect Dis, 2015;15(0):35.
Species: Human
Sample Type: Plasma

T-cell engager-armed oncolytic vaccinia virus significantly enhances antitumor therapy.
Authors: Yu F, Wang X, Guo Z, Bartlett D, Gottschalk S, Song X
Mol Ther, 2014;22(1):102-11.
Species: Human
Sample Type: Cell Culture Supernates

Interferon-gamma production by human neutrophils upon stimulation by IL-12, IL-15 and IL-18 and challenge with Paracoccidioides brasiliensis.
Authors: Rodrigues D, Fernandes R, Balderramas H, Penitenti M, Bachiega T, Calvi S, Dias-Melicio L, Ikoma M, Soares A
Cytokine, 2014;69(1):102-9.
Species: Human
Sample Type: Cell Culture Supernates

CD137 ligand signalling induces differentiation of primary acute myeloid leukaemia cells.
Authors: Cheng K, Wong S, Linn Y, Ho L, Chng W, Schwarz H
Br J Haematol, 2014;165(1):134-44.
Species: Human
Sample Type: Cell Culture Supernates

TNF-alpha blockade induces IL-10 expression in human CD4+ T cells.
Authors: Evans H, Roostalu U, Walter G, Gullick N, Frederiksen K, Roberts C, Sumner J, Baeten D, Gerwien J, Cope A, Geissmann F, Kirkham B, Taams L
Nat Commun, 2014;5(0):3199.
Species: Human
Sample Type: Cell Culture Supernates

Human CD4+ T cell responses to the dog major allergen Can f 1 and its human homologue tear lipocalin resemble each other.
Authors: Liukko A, Kinnunen T, Rytkonen-Nissinen M, Kailaanmaki A, Randell J, Maillere B, Virtanen T
PLoS ONE, 2014;9(5):e98461.

Specific targeting of a naturally presented osteosarcoma antigen, papillomavirus binding factor peptide, using an artificial monoclonal antibody.
Authors: Tsukahara T, Emori M, Murata K, Hirano T, Muroi N, Kyono M, Toji S, Watanabe K, Torigoe T, Kochin V, Asanuma H, Matsumiya H, Yamashita K, Himi T, Ichimiya S, Wada T, Yamashita T, Hasegawa T, Sato N
J Biol Chem, 2014;289(32):22035-47.
Species: Human
Sample Type: Cell Culture Supernates

A functional variant of PTPN22 confers risk for Vogt-Koyanagi-Harada syndrome but not for ankylosing spondylitis.
Authors: Zhang Q, Qi J, Hou S, DU L, Yu H, Cao Q, Zhou Y, Liao D, Kijlstra A, Yang P
PLoS ONE, 2014;9(5):e96943.
Species: Human
Sample Type: Cell Culture Supernates

TLR3 impairment in human newborns.
Authors: Slavica L, Nordstrom I, Karlsson M, Valadi H, Kacerovsky M, Jacobsson B, Eriksson K
J Leukoc Biol, 2013;94(5):1003-11.
Species: Human
Sample Type: Cell Culture Supernates

CD137L-stimulated dendritic cells are more potent than conventional dendritic cells at eliciting cytotoxic T-cell responses.
Authors: Harfuddin Z, Kwajah S, Chong Nyi Sim A, Macary P, Schwarz H
Oncoimmunology, 2013;2(11):e26859.
Species: Human
Sample Type: Cell culture supernatant

Elevated adaptive immune responses are associated with latent infections of Wuchereria bancrofti.
Authors: Arndts K, Deininger S, Specht S, Klarmann U, Mand S, Adjobimey T, Debrah AY, Batsa L, Kwarteng A, Epp C, Taylor M, Adjei O, Layland LE, Hoerauf A
PLoS Negl Trop Dis, 2012;6(4):e1611.
Species: Human
Sample Type: Cell Culture Supernates

IL-38 binds to the IL-36 receptor and has biological effects on immune cells similar to IL-36 receptor antagonist.
Authors: van de Veerdonk FL, Stoeckman AK, Wu G, Boeckermann AN, Azam T, Netea MG, Joosten LA, Van der Meer JW, Hao R, Kalabokis V, Dinarello CA
Proc. Natl. Acad. Sci. U.S.A., 2012;109(8):3001-5.
Species: Human
Sample Type: Cell Culture Supernates

NKG2D receptor regulates human effector T-cell cytokine production.
Authors: Barber A, Sentman CL
Blood, 2011;117(24):6571-81.
Species: Human
Sample Type: Cell Culture Supernates

Mutations of the von Hippel-Lindau gene confer increased susceptibility to natural killer cells of clear-cell renal cell carcinoma.
Authors: Perier A, Fregni G, Wittnebel S, Gad S, Allard M, Gervois N, Escudier B, Azzarone B, Caignard A
Oncogene, 2011;30(23):2622-32.
Species: Human
Sample Type: Cell Culture Supernates

Elevated serum osteopontin levels and genetic polymorphisms of osteopontin are associated with Vogt-Koyanagi-Harada disease.
Authors: Chu M, Yang P, Hu R, Hou S, Li F, Chen Y, Kijlstra A
Invest. Ophthalmol. Vis. Sci., 2011;52(10):7084-9.
Species: Human
Sample Type: Cell Culture Supernates

Serum levels of Th17-related cytokines in Behcet disease patients after cataract surgery.
Authors: Jiang S, Liu X, Luo L, Qu B, Huang X, Lin Y, Ye S, Liu Y
Mol. Vis., 2011;17(0):1425-30.
Species: Human
Sample Type: Serum

The effects of vaccine timing on the efficacy of an acute eccentric exercise intervention on the immune response to an influenza vaccine in young adults.
Authors: Campbell JP, Edwards KM, Ring C
Brain Behav. Immun., 2010;24(2):236-42.
Species: Human
Sample Type: Plasma

Immunoregulation of autocrine prolactin: suppressing the expression of costimulatory molecules and cytokines in T lymphocytes by prolactin receptor knockdown.
Authors: Xu D, Lin L, Lin X
Cell. Immunol., 2010;263(1):71-8.
Species: Human
Sample Type: Cell Culture Supernates

IL-17 amplifies human contact hypersensitivity by licensing hapten nonspecific Th1 cells to kill autologous keratinocytes.
Authors: Pennino D, Eyerich K, Scarponi C, Carbone T, Eyerich S, Nasorri F, Garcovich S, Traidl-Hoffmann C, Albanesi C, Cavani A
J. Immunol., 2010;184(9):4880-8.
Species: Human
Sample Type: Cell Culture Supernates

Der p 1 suppresses indoleamine 2, 3-dioxygenase in dendritic cells from house dust mite-sensitive patients with asthma.
Authors: Maneechotesuwan K, Wamanuttajinda V, Kasetsinsombat K, Huabprasert S, Yaikwawong M, Barnes PJ, Wongkajornsilp A
J. Allergy Clin. Immunol., 2009;123(1):239-48.
Species: Human
Sample Type: Cell Culture Supernates

Detuning CD8+ T lymphocytes by down-regulation of the activating receptor NKG2D: role of NKG2D ligands released by activated T cells.
Authors: Cerboni C, Ardolino M, Santoni A, Zingoni A
Blood, 2009;113(13):2955-64.
Species: Human
Sample Type: Cell Culture Supernates

Interleukin-17 and interferon-gamma are produced concomitantly by human coronary artery-infiltrating T cells and act synergistically on vascular smooth muscle cells.
Authors: Eid RE, Rao DA, Zhou J, Lo SF, Ranjbaran H, Gallo A, Sokol SI, Pfau S, Pober JS, Tellides G
Circulation, 2009;119(10):1424-32.
Species: Human
Sample Type: Plasma

TLR2-activated human langerhans cells promote Th17 polarization via IL-1beta, TGF-beta and IL-23.
Authors: Aliahmadi E, Gramlich R, Grutzkau A, Hitzler M, Kruger M, Baumgrass R, Schreiner M, Wittig B, Wanner R, Peiser M
Eur. J. Immunol., 2009;39(5):1221-30.
Species: Human
Sample Type: Cell Culture Supernates

Interferon-beta treatment in multiple sclerosis attenuates inflammatory gene expression through inducible activity of the phosphatase SHP-1.
Authors: Christophi GP, Panos M, Hudson CA, Tsikkou C, Mihai C, Mejico LJ, Jubelt B, Massa PT
Clin. Immunol., 2009;133(1):27-44.
Species: Human
Sample Type: Plasma

Fungal proteases induce Th2 polarization through limited dendritic cell maturation and reduced production of IL-12.
Authors: Lamhamedi-Cherradi SE, Martin RE, Ito T, Kheradmand F, Corry DB, Liu YJ, Moyle M
J. Immunol., 2008;180(9):6000-9.
Species: Human
Sample Type: Cell Culture Supernates

Helminth infections associated with multiple sclerosis induce regulatory B cells.
Authors: Correale J, Farez M, Razzitte G
Ann. Neurol., 2008;64(2):187-99.
Species: Human
Sample Type: Cell Culture Supernates

alpha1beta1 integrin and interleukin-7 receptor up-regulate the expression of RANKL in human T cells and enhance their osteoclastogenic function.
Authors: Gendron S, Boisvert M, Chetoui N, Aoudjit F
Immunology, 2008;125(0):359.
Species: Human
Sample Type: Cell Culture Supernates

Diminished frequency and function of CD4+CD25high regulatory T cells associated with active uveitis in Vogt-Koyanagi-Harada syndrome.
Authors: Chen L, Yang P, Zhou H, He H, Ren X, Chi W, Wang L, Kijlstra A
Invest. Ophthalmol. Vis. Sci., 2008;49(8):3475-82.
Species: Human
Sample Type: Cell Culture Supernates

Adenosine receptors in regulation of dendritic cell differentiation and function.
Authors: Novitskiy SV, Ryzhov S, Zaynagetdinov R, Goldstein AE, Huang Y, Tikhomirov OY, Blackburn MR, Biaggioni I, Carbone DP, Feoktistov I, Dikov MM
Blood, 2008;112(5):1822-31.
Species: Human
Sample Type: Cell Culture Supernates

Neuroimmune crosstalk in asthma: dual role of the neurotrophin receptor p75NTR.
Authors: Nassenstein C, Kammertoens T, Veres TZ, Uckert W, Spies E, Fuchs B, Krug N, Braun A
J. Allergy Clin. Immunol., 2007;120(5):1089-96.
Species: Mouse
Sample Type: BALF

Chimeric NKG2D receptor-bearing T cells as immunotherapy for ovarian cancer.
Authors: Barber A, Zhang T, DeMars LR, Conejo-Garcia J, Roby KF, Sentman CL
Cancer Res., 2007;67(10):5003-8.
Species: Human
Sample Type: Cell Culture Supernates

IL-24 modulates IFN-gamma expression in patients with tuberculosis.
Authors: Wu B, Huang C, Kato-Maeda M, Hopewell PC, Daley CL, Krensky AM, Clayberger C
Immunol. Lett., 2007;117(1):57-62.
Species: Human
Sample Type: Cell Culture Supernates

The differential effect of Eriobotrya japonica hydrophilic leaf extract on cytokines production and modulation.
Authors: Matalka KZ, Ali D, Khawad AE, Qa'dan F
Cytokine, 2007;40(3):235-40.
Species: Human
Sample Type: Cell Culture Supernates

The direct effects of Toll-like receptor ligands on human NK cell cytokine production and cytotoxicity.
Authors: Lauzon NM, Mian F, MacKenzie R, Ashkar AA
Cell. Immunol., 2006;241(2):102-12.
Species: Human
Sample Type: Cell Culture Supernates

An investigation of auto-reactivity after head injury.
Authors: Cox AL, Coles AJ, Nortje J, Bradley PG, Chatfield DA, Thompson SJ, Menon DK
J. Neuroimmunol., 2006;174(1):180-6.
Species: Human
Sample Type: Cell Culture Supernates

A combination of E. coli DNA fragments and modified lipopolysaccharides as a cancer immunotherapy.
Authors: Cho YJ, Ahn BY, Lee NG, Lee DH, Kim DS
Vaccine, 2006;24(31):5862-71.
Species: Human
Sample Type: Cell Culture Supernates

IL-15 and the initiation of cell contact-dependent synovial fibroblast-T lymphocyte cross-talk in rheumatoid arthritis: effect of methotrexate.
Authors: Miranda-Carus ME, Balsa A, Benito-Miguel M, Perez de Ayala C, Martin-Mola E
J. Immunol., 2004;173(2):1463-76.
Species: Human
Sample Type: Cell Culture Supernates

Immune responses in normal Indian langur monkeys (Presbytis entellus)--a primate model for visceral leishmaniasis.
Authors: Misra A, Dube A, Naik S
J. Med. Primatol., 2004;33(2):65-9.
Species: Primate - Presbytis entellus (Indian langur)
Sample Type: Cell Culture Supernates

Association of type 2 cytokines with hepatic fibrosis in human Schistosoma mansoni infection.
Authors: de Jesus AR, Magalhaes A, Miranda DG, Miranda RG, Araujo MI, de Jesus AA, Silva A, Santana LB, Pearce E, Carvalho EM
Infect. Immun., 2004;72(6):3391-7.
Species: Human
Sample Type: Cell Culture Supernates

The Toll-like receptor-2/6 agonist macrophage-activating lipopeptide-2 cooperates with IFN-gamma to reverse the Th2 skew in an in vitro allergy model.
Authors: Weigt H, Muhlradt PF, Larbig M, Krug N, Braun A
J. Immunol., 2004;172(10):6080-6.
Species: Human
Sample Type: Cell Culture Supernates

Activation of resting human primary T cells with chimeric receptors: costimulation from CD28, inducible costimulator, CD134, and CD137 in series with signals from the TCR zeta chain.
Authors: Finney HM, Akbar AN, Lawson AD
J. Immunol., 2004;172(1):104-13.
Species: Human
Sample Type: Cell Culture Supernates

Stimulation of T cell autoreactivity by anomalous expression of NKG2D and its MIC ligands in rheumatoid arthritis.
Authors: Groh V, Bruhl A, El-Gabalawy H, Nelson JL, Spies T
Proc. Natl. Acad. Sci. U.S.A., 2003;100(16):9452-7.
Species: Human
Sample Type: Cell Culture Supernates

Toxoplasma gondii induces granulocyte colony-stimulating factor and granulocyte-macrophage colony-stimulating factor secretion by human fibroblasts: implications for neutrophil apoptosis.
Authors: Channon JY, Miselis KA, Minns LA, Dutta C, Kasper LH
Infect. Immun., 2002;70(11):6048-57.
Species: Human
Sample Type: Cell Culture Supernates

Natural killer cell-produced IFN-gamma and TNF-alpha induce target cell cytolysis through up-regulation of ICAM-1.
Authors: Wang R, Jaw JJ, Jaw J, Stutzman N, Stutzman NC, Zou Z, Sun PD
J Leukoc Biol, 0;91(2):299-309.
Species: Human
Sample Type: Cell Culture Supernates

背景

IFN-gamma (Interferon-gamma) is the prototype proinflammatory cytokine and is produced by a variety of immune cells under inflammatory conditions, notably by T cells and NK cells. It plays a key role in host defense by promoting the development and activation of Th1 cells, chemoattraction and activation of monocytes and macrophages, upregulation of antigen presentation molecules, and immunoglobulin class switching in B cells. It also exhibits antiviral, antiproliferative, and apoptotic effects. In addition, IFN-gamma functions as an anti-inflammatory mediator by promoting the development of regulatory T cells and inhibiting Th17 cell differentiation. IFN-gamma dimers signal through a receptor complex of two IFN-gamma R1 and two IFN-gamma R2 subunits.

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货号:DY285B-05

规格: 1Kit(for5Plates)
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请您下单前确定实验服务合同结束后,样本处置情况。我们将严格按照合同约定执行。若您选择实验结束后样本,不保留,丢弃,我们会在实验结束后按国家标准自行处置掉相关实验材料。若您需要回寄相关样本,在您支付一定的运输费用后,我们将剩余样本在规定时间内返还给您。若您选择到付,需要保证您的样本是常温和蓝冰运输的,更高要求的运输条件不支持货到付款。若您不确定是否回寄,我们将保持您的样本1个月的时间,如超期,样本我们将自行处置,不在另行通知您。 如果您选择我们回寄样本给您,我们将快递信息邮件告知您,由您跟踪物流信息,并及时确认。如因您个人原因或者第三方物流原因造成的样本邮寄过程中的损耗,我们不承担任何责任。

5.实验服务种实验服务数据:

1) 我们承诺按照《实验样本信息及要求》中的实验方案进行实验并提供客观实验结果,但由于科研实验中存在诸多不确定因素以及未知难度和风险而导致结果的不确定性,不能保证所有的实验进度和实验结果完全达到甲方预期。在排除实验操作问题导致不良结果的前提下,您应尊重客观事实,承担实验结果与预期不一致的结果,包括实验结果是阴性的风险。因此在得不到预期结果的情况下,您仍应支付本次实验服务的全部已发生费用。

2) 实验服务是由专业技术达标的实验人员,遵循科学实验方法和标准操作流程,依照服务合同完成,优宁维保证将客观真实科学严谨的实验结果给到客户,但单次实验不足以阐明某些复杂的科学问题。

3) 您在收到实验数据后,5个工作日内(荧光相关实验3个工作日内)对实验数据质量提质疑,我们有义务解答。若是我们实验过程中的问题,我们承担全部责任;若是您验设计问题,您承担全部责任。我们承诺1个月的数据复核期,欢迎后续咨询。

6.客户知识产权保密协议:

1) 实验服务过程中产生的实验数据的知识产权归您所有,我们承诺不得以任何形式向除甲方以外的第三方提供该实验数据。对于相关的实验技术所有权归我们所有,您不得主张权利。

2) 我们双方共同致力于维护对方的商业机密和技术机密,包括本次合同所签订的文件,您都有义务进行保密。

7.服务承诺

如由于实验客观性需要重复实验、自然灾害、政府行为或其他乙方无法预见、无法避免和无法克服等不可抗力的客观原因造成合同无法按期履行的,我们将及时通知甲方,双方将视情况决定是否继续履行合同。如果由于客观原因造成某些实验项目不能执行的,合同结束时,退回相应款项。

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